XSB2340 : Chain A, Structure Of Native Human Beta B2 Crystallin
[ CaMP Format ]
This entry is computationally expanded from SB0082
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp |
| Gene Names | CRYB2, CRYB2A; CRYB2; CRYB2A |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 204 aa
Average Mass: 23.249 kDa
Monoisotopic Mass: 23.234 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| --- cleavage 7 --- |
| Crystall 1. | 17 | 99 | 163.1 | 8.4e-46 |
| Crystall 2. | 107 | 189 | 164.3 | 3.5e-46 |
3. Sequence Information
Fasta Sequence: XSB2340.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB:
1YTQ (X-ray; 170 A; A=2-205)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] ASDHQTQ7-AGKPQSLNPK
Gln7 
Ala
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| - | - | - | Ala1 | Ser2 | Asp3 | His4 | Gln5 | Thr6 | Gln7 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ala8 | Gly9 | Lys10 | Pro11 | Gln12 | Ser13 | Leu14 | Asn15 | Pro16 | Lys17 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
ASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPC
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
82.80 |
2 |
crystallin, beta B2 |
| 2 |
human, lens, Peptide, 204 aa |
82.80 |
1 |
A Chain A, Structure Of Native Human Beta B2 Cryst |
| 3 |
Macaca mulatta |
80.90 |
2 |
PREDICTED: crystallin, beta B2 isoform 3 |
| 4 |
Bos taurus |
80.90 |
2 |
crystallin, beta B2 |
| 5 |
Oryctolagus cuniculus |
80.90 |
1 |
crystallin, beta B2 |
| 6 |
N/A |
79.00 |
5 |
A |
| 7 |
Canis lupus familiaris |
79.00 |
1 |
crystallin, beta B2 |
| 8 |
Mus musculus |
79.00 |
1 |
crystallin, beta B2 |
| 9 |
Cavia porcellus |
77.80 |
1 |
betaB2-crystallin |
| 10 |
Rana catesbeiana |
55.50 |
1 |
CRBB2_RANCA Beta crystallin B2 (Beta-crystallin Bp |
| 11 |
Xenopus laevis |
54.30 |
5 |
MGC84818 protein |
| 12 |
Gallus gallus |
51.60 |
3 |
CRBB2_CHICK Beta crystallin B2 (Beta-crystallin Bp |
| 13 |
Pan troglodytes |
49.30 |
2 |
PREDICTED: crystallin, beta B3 isoform 3 |
| 14 |
Monodelphis domestica |
47.40 |
2 |
PREDICTED: similar to betaB2-crystallin |
| 15 |
Danio rerio |
45.80 |
2 |
PREDICTED: beta B2-crystallin isoform 1 |
| 16 |
Tetraodon nigroviridis |
42.70 |
2 |
unnamed protein product |
| 17 |
Xenopus tropicalis |
34.70 |
1 |
crystallin, beta B1 |
| 18 |
Canis familiaris |
34.30 |
1 |
PREDICTED: similar to crystallin, beta B1 |
| 19 |
Dicentrarchus labrax |
33.90 |
1 |
crystallin beta B1 |
| 20 |
Sus scrofa |
32.70 |
1 |
beta crystallin subunit beta B1 |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||||||||||||||||||||||||||||
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|
| human, lens, Peptide, 204 aa |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||||||||||||||||||||||||||||
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|
| Macaca mulatta |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||||||||||||||||||||||||+|||
Sbjct 2 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELSGPC 38
|
| Bos taurus |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||| ||||||||||||||||||||||||
Sbjct 2 ASDHQTQ#AGKPQPLNPKIIIFEQENFQGHSHELNGPC 38
|
| Oryctolagus cuniculus |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||| ||||||||||||||||||||||||
Sbjct 2 ASDHQTQ#AGKPQPLNPKIIIFEQENFQGHSHELNGPC 38
|
| N/A |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||| ||||||||||||||||||||+|||
Sbjct 1 ASDHQTQ#AGKPQPLNPKIIIFEQENFQGHSHELSGPC 37
|
| Canis lupus familiaris |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||| ||||||||||||||||||||+|||
Sbjct 2 ASDHQTQ#AGKPQPLNPKIIIFEQENFQGHSHELSGPC 38
|
| Mus musculus |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||||| ||||||||||||||||||||+|||
Sbjct 2 ASDHQTQ#AGKPQPLNPKIIIFEQENFQGHSHELSGPC 38
|
| Cavia porcellus |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||||#||| | ||||||||||||||||||||||||
Sbjct 2 ASDHQTQ#AGKQQPLNPKIIIFEQENFQGHSHELNGPC 38
|
| Rana catesbeiana |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||+ #| | | + ||++|||||||| |||+|||
Sbjct 2 ASDHQSP#ATKQQQPSSKIVLFEQENFQGRCHELSGPC 38
|
| Xenopus laevis |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|||||| #+| | | |++|+||||||| |||||| |
Sbjct 2 ASDHQT-#SGTKQQQNAKLVIYEQENFQGRSHELNGAC 37
|
| Gallus gallus |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
||+|| #| | | +| | ||||||||| |||+| |
Sbjct 2 ASEHQMP#ASKQQPASPNIAIFEQENFQGRCHELSGAC 38
|
| Pan troglodytes |
Query 10 KPQSLNPKIIIFEQENFQGHSHELNGPC 37
+ | +||||||||||||||||||||
Sbjct 198 RDQKGGSRIIIFEQENFQGHSHELNGPC 225
|
| Monodelphis domestica |
Query 16 PKIIIFEQENFQGHSHELNGPC 37
|||+||||||||| ||||+|||
Sbjct 396 PKIVIFEQENFQGRSHELSGPC 417
|
| Danio rerio |
Query 1 ASDHQTQ#AGK---PQSLNPKIIIFEQENFQGHSHELNGPC 37
|+||| #| | | + |++|+||||||| ||| |||
Sbjct 2 ATDHQNP#ATKQKQPVASAFKLVIYEQENFQGRCHELTGPC 41
|
| Tetraodon nigroviridis |
Query 1 ASDHQTQ#AGKPQSLNP---KIIIFEQENFQGHSHELNGPC 37
|+||| #| | | + |++|+|||||||| ||+ |
Sbjct 26 ATDHQNP#ASKQQQPSASAFKLVIYEQENFQGHCQELSAAC 65
|
| Xenopus tropicalis |
Query 6 TQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|+# | | + ||++|||||||| || |
Sbjct 27 TR#TGDPMMGSFKIVLFEQENFQGRHVELLNEC 58
|
| Canis familiaris |
Query 6 TQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|+#|| + |+++|||||||| | +| |
Sbjct 45 TK#AGDLPPGSYKLVVFEQENFQGRRVEFSGEC 76
|
| Dicentrarchus labrax |
Query 1 ASDHQTQ#AGKPQSLNPKIIIFEQENFQGHSHELNGPC 37
|| |+# |+| + +|++|+|||||| |+ |
Sbjct 25 ASSKATK#TGEPGMGSYRIMMFDQENFQGRMIEVQNEC 61
|
| Sus scrofa |
Query 17 KIIIFEQENFQGHSHELNGPC 37
|+++|||||||| | +| |
Sbjct 57 KLVVFEQENFQGRRVEFSGEC 77
|
* References
[PubMed ID: 17327390] Smith MA, Bateman OA, Jaenicke R, Slingsby C, Mutation of interfaces in domain-swapped human betaB2-crystallin. Protein Sci. 2007 Apr;16(4):615-25. Epub 2007 Feb 27.
