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XSB2347 : Jun oncogene [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0086

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesTranscription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; Jun A; AH119; Jun oncogene; immediate early
Gene NamesJun; Jun oncogene
Gene Locus4 44.6 cM; chromosome 4
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_034721 NM_010591 16476 JUN_MOUSE N/A N/A N/A mmu:16476

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 334 aa

Average Mass: 35.944 kDa

Monoisotopic Mass: 35.921 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Jun 1. 5244442.75.7e-130
--- cleavage 90 (inside Jun 5..244) ---
--- cleavage 62 (inside Jun 5..244) ---
--- cleavage 42 (inside Jun 5..244) ---
bZIP_1 1. 25331684.92.9e-22

3. Sequence Information

Fasta Sequence: XSB2347.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] IQSSNGHITT90-TPTPTQFLCP

Thr90 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile81Gln82Ser83Ser84Asn85Gly86His87Ile88Thr89Thr90
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr91Pro92Thr93Pro94Thr95Gln96Phe97Leu98Cys99Pro100

Sequence conservation (by blast)

[Site 2] LRAKNSDLLT62-SPDVGLLKLA

Thr62 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu53Arg54Ala55Lys56Asn57Ser58Asp59Leu60Leu61Thr62
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser63Pro64Asp65Val66Gly67Leu68Leu69Lys70Leu71Ala72

Sequence conservation (by blast)

[Site 3] ILKQSMTLNL42-ADPVGSLKPH

Leu42 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile33Leu34Lys35Gln36Ser37Met38Thr39Leu40Asn41Leu42
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala43Asp44Pro45Val46Gly47Ser48Leu49Lys50Pro51His52

Sequence conservation (by blast)

* References

[PubMed ID: 19369394] Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC, FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development. 2009 May;136(10):1741-50. Epub 2009 Apr 15.

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