XSB2353 : jun oncogene [Xenopus laevis]
[ CaMP Format ]
This entry is computationally expanded from SB0086
* Basic Information
| Organism | Xenopus laevis (African clawed frog) |
| Protein Names | Jun protein; jun oncogene; v-jun sarcoma virus 17 oncogene homolog |
| Gene Names | jun; jun oncogene |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001079363 | NM_001085894 | 379050 | Q8AVE4_XENLA | N/A | N/A | N/A | xla:379050 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 312 aa
Average Mass: 34.393 kDa
Monoisotopic Mass: 34.371 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Jun 1. | 5 | 222 | 458.7 | 8.7e-135 |
| --- cleavage 88 (inside Jun 5..222) --- | ||||
| bZIP_1 1. | 231 | 294 | 85.2 | 2.4e-22 |
3. Sequence Information
Fasta Sequence: XSB2353.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] IQSSNGMITT88-TPTPTQFLCP
Thr88 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile79 | Gln80 | Ser81 | Ser82 | Asn83 | Gly84 | Met85 | Ile86 | Thr87 | Thr88 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr89 | Pro90 | Thr91 | Pro92 | Thr93 | Gln94 | Phe95 | Leu96 | Cys97 | Pro98 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LTSPDVGLLKLASPELERLIIQSSNGMITTTPTPTQFLCPKNVTDEQEGFADGFVRALAE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Xenopus laevis | 121.00 | 7 | c-Jun protein |
| 2 | Danio rerio | 120.00 | 5 | c-Jun protein |
| 3 | N/A | 119.00 | 7 | J |
| 4 | Monodelphis domestica | 119.00 | 2 | PREDICTED: similar to fc49b10 G-protein coupled re |
| 5 | Ctenopharyngodon idella | 119.00 | 2 | c-Jun protein |
| 6 | Gallus gallus | 119.00 | 2 | jun oncogene |
| 7 | Serinus canaria | 119.00 | 1 | JUN_SERCA Transcription factor AP-1 (Proto-oncogen |
| 8 | Crocodylus niloticus | 119.00 | 1 | c-jun |
| 9 | Coturnix coturnix | 119.00 | 1 | JUN_COTJA Transcription factor AP-1 (Proto-oncogen |
| 10 | Alligator mississippiensis | 119.00 | 1 | c-jun |
| 11 | Pseudemys nelsoni | 119.00 | 1 | c-jun |
| 12 | Carassius auratus | 118.00 | 1 | c-Jun protein |
| 13 | Mus musculus | 117.00 | 11 | unnamed protein product |
| 14 | Homo sapiens | 117.00 | 10 | JUN |
| 15 | Canis familiaris | 117.00 | 10 | PREDICTED: similar to Transcription factor AP-1 (A |
| 16 | Bos taurus | 117.00 | 5 | jun oncogene |
| 17 | synthetic construct | 117.00 | 5 | v-jun sarcoma virus 17 oncogene-like |
| 18 | Rattus norvegicus | 117.00 | 5 | v-jun sarcoma virus 17 oncogene homolog |
| 19 | Macaca mulatta | 117.00 | 2 | PREDICTED: similar to Transcription factor AP-1 (A |
| 20 | Sus scrofa | 117.00 | 1 | C-JUN protein |
| 21 | Macaca fuscata | 117.00 | 1 | transcription factor c-Jun |
| 22 | Oryctolagus cuniculus | 117.00 | 1 | c-jun transcription factor |
| 23 | Tetraodon nigroviridis | 116.00 | 6 | unnamed protein product |
| 24 | Oncorhynchus mykiss | 114.00 | 2 | transcription factor AP-1 |
| 25 | Takifugu rubripes | 112.00 | 6 | c-Jun protein |
| 26 | Xiphophorus maculatus | 104.00 | 2 | c-JUN |
| 27 | Ovis aries | 87.80 | 2 | c-Jun protein |
| 28 | Pan troglodytes | 81.60 | 2 | PREDICTED: jun D proto-oncogene |
| 29 | Cyprinus carpio | 78.20 | 1 | JUNB_CYPCA Transcription factor jun-B gb |
| 30 | Strongylocentrotus purpuratus | 76.60 | 1 | PREDICTED: similar to transcription factor AP-1 |
| 31 | Apis mellifera | 66.60 | 1 | PREDICTED: similar to c-Jun protein |
| 32 | Aedes aegypti | 57.80 | 1 | jun |
| 33 | Anopheles gambiae str. PEST | 52.40 | 1 | ENSANGP00000020405 |
| 34 | Xenopus tropicalis | 48.50 | 1 | jun B proto-oncogene |
| 35 | Ciona intestinalis | 43.10 | 1 | transcription factor protein |
| 36 | Tribolium castaneum | 41.60 | 1 | PREDICTED: similar to Transcription factor AP-1 (J |
| 37 | Poecilia reticulata | 36.20 | 1 | transcription factor JunB |
| 38 | Drosophila pseudoobscura | 34.30 | 1 | GA15338-PA |
| 39 | Schistosoma japonicum | 33.90 | 1 | SJCHGC03684 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Xenopus laevis | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |
| Danio rerio | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||+|||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| N/A | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Monodelphis domestica | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Ctenopharyngodon idella | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Gallus gallus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Serinus canaria | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Crocodylus niloticus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Coturnix coturnix | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Alligator mississippiensis | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Pseudemys nelsoni | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Carassius auratus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||+|| ||||| Sbjct 56 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFARALAE 115 |
| Mus musculus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Homo sapiens | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Canis familiaris | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Bos taurus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| synthetic construct | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Rattus norvegicus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Macaca mulatta | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Sus scrofa | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Macaca fuscata | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Oryctolagus cuniculus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||||||||||||||||||||||| |||#|||||||||||||||||||||+|||||||| Sbjct 8 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 67 |
| Tetraodon nigroviridis | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||+||||||+||||||+|||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFICPKNVTEEQEGFAEGFVRALAE 119 |
| Oncorhynchus mykiss | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |||||| |||||||||||||||||||+|||#||||||||||+||||||||||+|||||||| Sbjct 59 LTSPDVQLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPRNVTDEQEGFAEGFVRALAE 118 |
| Takifugu rubripes | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||||||+|||#|||||||+ |||||+||||||+|||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFISPKNVTEEQEGFAEGFVRALAE 119 |
| Xiphophorus maculatus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 ||||||||||||||||||||||| +|+ |#|||||||+|||||+|||||||+|||||||| Sbjct 62 LTSPDVGLLKLASPELERLIIQSCSGL--T#TPTPTQFICPKNVSDEQEGFAEGFVRALAE 119 |
| Ovis aries | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVT 102 |||||||||||||||||||||||||| |||#|||||||||||||| Sbjct 47 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVT 90 |
| Pan troglodytes | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 | |||+||||||||||||||||| ||++||#||| +||| || |++ ||+|||+|| + Sbjct 88 LASPDLGLLKLASPELERLIIQS-NGLVTT#TPTSSQFLYPKVAASEEQEFAEGFVKALED 146 |
| Cyprinus carpio | Query 63 DVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 | | ||||||||||||||+|||++||# ||| |+| + +||||||||+|||+|| Sbjct 58 DSGSLKLASPELERLIIQTSNGVLTT#-PTPGQYLYSRGITDEQEGFAEGFVKAL 110 |
| Strongylocentrotus purpuratus | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 |++||| +|||||||||++|| | | | |#|||| ||+ |||||+|| || ||| || Sbjct 38 LSTPDVQMLKLASPELEKMII-SQQGNICT#TPTPGQFISPKNVTEEQAAFAQGFVEAL 94 |
| Apis mellifera | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |+|||+ +|||+|||||+ || + ++| # |||| | || ||+ || +| ||| || | Sbjct 61 LSSPDLNMLKLSSPELEKFIIAQQDSLVTN#LVTPTQILFPKAVTEAQELYARGFVDALNE 120 |
| Aedes aegypti | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 +||||+ +||| |||||++|| | #||||+ | | | ||| || || || Sbjct 65 ITSPDLQVLKLVSPELEKIII---NSAALP#TPTPSSILYPTKATTEQEQFAKGFDEAL 119 |
| Anopheles gambiae str. PEST | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 | |||+ +||| |||||++| | #||||+ + | + | ||+ || || || Sbjct 14 LPSPDLQMLKLVSPELEKII---STNATLP#TPTPSAIIFPPSATSEQQQFAKGFEDAL 68 |
| Xenopus tropicalis | Query 62 PDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKN--VTDEQEGFADGFVRAL 116 | ||+|+|||||+|| | |+|+ # + + +|+||||| ||||+|| Sbjct 61 PAPSSLKMAAPELERMIIHSGPGVISG#PSGGQLYYSSRGNGITEEQEGFVDGFVKAL 117 |
| Ciona intestinalis | Query 59 LTSPD-VGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 |++|| | +||+ ||+ +|+++ || #| +|| +| | ||| +| |||| | Sbjct 134 LSTPDLVNMLKVGSPDFDRMLVHSSQA---N#TQNNSQFF-QRNATQEQEIYAQGFVREL 188 |
| Tribolium castaneum | Query 61 SPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRAL 116 +|| |||+ +| +| +|+ ++ |+ #||+|+ + |++|| ||| || ||| || Sbjct 32 TPD--LLKVDTPTIENIILANN---ISH#TPSPS-LIFPRDVTVEQEKFAGGFVEAL 81 |
| Poecilia reticulata | Query 94 QFLCPKNVTDEQEGFADGFVRALAE 118 |+ + +||||||||+|||+|| | Sbjct 1 QYFYNRGITDEQEGFAEGFVKALDE 25 |
| Drosophila pseudoobscura | Query 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPK--NVTDEQEGFADGFVRAL 116 + |||+ + +|+||++++ || |+ |# | | + | || ||| | || || Sbjct 82 INSPDLQAKTVNTPDLEKILL--SNHMMQT#-PQPGKVFPTKVGPVTSEQEAFGKGFEEAL 138 |
| Schistosoma japonicum | Query 66 LLKLASPELERL--IIQSSNGMI-----TT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 | +| || | |++| | +# || || ||+||+||| ||+ | + | | Sbjct 66 LSSFLTPSLEELQPILRSEVEKILQHLKAS#PQTPGSFLNPKHVTEEQERFANVFTQKLNE 125 |
* References
[PubMed ID: 12454917] Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P, Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Dev Dyn. 2002 Dec;225(4):384-91.
[PubMed ID: 11044605] ... Knochel S, Schuler-Metz A, Knochel W, c-Jun (AP-1) activates BMP-4 transcription in Xenopus embryos. Mech Dev. 2000 Nov;98(1-2):29-36.