CaMPDB :: Substrate

XSB2365 : PREDICTED: similar to Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) [Pan troglodytes]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

Organism	Pan troglodytes (chimpanzee)
Protein Names	similar to Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3)
Gene Names	LOC453363; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 82 ESTs, 22 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_510336	XM_510336	453363	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 796 aa

Average Mass: 91.193 kDa

Monoisotopic Mass: 91.134 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	74	369	779.6	2.2e-231
--- cleavage 316 (inside Peptidase_C2 74..369) ---
--- cleavage 342 (inside Peptidase_C2 74..369) ---
Calpain_III 1.	380	534	364.8	1.6e-106
Osmo_CC 1.	618	663	2.9	6
efhand 1.	671	699	27.9	4e-05
efhand 2.	701	729	26.7	9.3e-05
efhand 3.	766	793	9.1	2.2

3. Sequence Information

Fasta Sequence: XSB2365.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] RLRNPWGQVE³¹⁶-WNGSWSDRWK

Glu³¹⁶ Trp

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Arg³⁰⁷	Leu³⁰⁸	Arg³⁰⁹	Asn³¹⁰	Pro³¹¹	Trp³¹²	Gly³¹³	Gln³¹⁴	Val³¹⁵	Glu³¹⁶

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Trp³¹⁷	Asn³¹⁸	Gly³¹⁹	Ser³²⁰	Trp³²¹	Ser³²²	Asp³²³	Arg³²⁴	Trp³²⁵	Lys³²⁶

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
AYSVTGLDEVLFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED

Summary

#	organism	max score	hits	top seq
1	Pan troglodytes	132.00	12	PREDICTED: similar to Calpain-3 (Calpain L3) (Calp
2	Homo sapiens	130.00	47	hCG40434, isoform CRA_d
3	Macaca mulatta	130.00	4	PREDICTED: calpain 3
4	Macaca fascicularis	130.00	1	CAN3_MACFA Calpain-3 (Calpain L3) (Calpain p94) (C
5	Mus musculus	127.00	33	calpain 3
6	N/A	127.00	18	1
7	Rattus norvegicus	127.00	16	AF184950_1 calpain Rt90
8	Sus scrofa	127.00	4	calpain 3
9	Oryctolagus cuniculus	127.00	1	calpain 3, (p94)
10	Bos taurus	125.00	11	calpain 3
11	Ovis aries	125.00	2	skeletal muscle-specific calpain
12	Canis familiaris	124.00	23	PREDICTED: similar to Calpain-3 (Calpain L3) (Calp
13	Monodelphis domestica	102.00	7	PREDICTED: similar to ZP1-related protein
14	Gallus gallus	99.00	7	calpain 3, (p94)
15	Oncorhynchus mykiss	87.40	4	gill-specific calpain
16	Danio rerio	84.00	24	hypothetical protein LOC445107
17	Tetraodon nigroviridis	81.60	6	unnamed protein product
18	Xenopus laevis	79.70	12	MGC83034 protein
19	Xenopus tropicalis	77.00	6	calpain 8 (nCL-2)
20	Caenorhabditis elegans	70.90	3	CaLPain family member (clp-6)
21	Pongo pygmaeus	70.10	1	CAN1_PONPY Calpain-1 catalytic subunit (Calpain-1
22	synthetic construct	69.70	1	Homo sapiens calpain 1, (mu/I) large subunit
23	catalytic	69.30	1	Calpain 2, large
24	Coturnix coturnix	69.30	1	quail calpain
25	Stizostedion vitreum vitreum	68.90	1	putative calpain-like protein
26	Bos grunniens	67.00	1	micromolar calcium-activated neutral protease 1 la
27	Strongylocentrotus purpuratus	65.50	1	PREDICTED: similar to calpain B isoform 2
28	Tribolium castaneum	64.30	1	PREDICTED: similar to calpain 8

Top-ranked sequences

organism	matching
Pan troglodytes	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346
Homo sapiens	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 335 AYSVTGLDEVPFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
Macaca mulatta	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 335 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 394
Macaca fascicularis	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 335 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 394
Mus musculus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 315 AYSVTGLEEALFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 374
N/A	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 335 AYSVTGLEEALFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 394
Rattus norvegicus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 315 AYSVTGLEEALFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 374
Sus scrofa	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 335 AYSVTGLEEALFKGEKVKLVRLRNPWGQVE#WNGSWSDSWKDWSFVDKDEKARLQHQVTED 394
Oryctolagus cuniculus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 267 AYSVTGLEETLFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKDEKARLQHQVTED 326
Bos taurus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 336 AYSVTGLEEALYKGEKVKLVRLRNPWGQVE#WNGSWSDSWKDWSYVDKDEKARLQHQVTED 395
Ovis aries	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 336 AYSVTGLEEALYKGEKVKLVRLRNPWGQVE#WNGSWSDSWKDWSYVDKDEKARLQHQVTED 395
Canis familiaris	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 292 AYSVTGLEEALFKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWSFVDKAEKARLQHQVTED 351
Monodelphis domestica	Query 298 FKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| +\|\|+\|\|+\|\|\|\|\|\|\|\|\| Sbjct 317 FKGEKVKLVRLRNPWGQVE#WNGSWSDGWKDWVLIDKEEKSRLQHQVTED 365
Gallus gallus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\| ++\| +\|\|\|\|++\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\| \|\|\|+ ++\|+\|+\|++\|\| \|\|\|\|++ \|\| Sbjct 328 AYSVTAVEETTYKGEKMRLVRLRNPWGQVE#WNGPWSDKSEEWNFIDEEEKIRLQHKIAED 387
Oncorhynchus mykiss	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|+\|\|\|+\|\| ++\|+\|\|\|\|+\|+\|\|\|\|\|\|\|\|#\|\|\|+\|\|\| ++\|+ +\| \|\| \|+ +\| Sbjct 241 AYSITGLEEVNYRGKKVKLIRIRNPWGQVE#WNGAWSDESREWNVIDSSEKKRILQNSMDD 300
Danio rerio	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|++\|\| ++\| \|\|+\|+\|+\|\|\|\|\|\|\|\|#\|\|\| \|\|\| ++\|+ +\| \|\| \|\| +\| Sbjct 253 AYSVTGVEEVNYRGAKVQLIRVRNPWGQVE#WNGPWSDNSREWTVIDSSEKKRLLQNSLDD 312
Tetraodon nigroviridis	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQ 342 \|\|\|\|\|\| \|+\| ++\|\| \|+\|\|\|+\|\|\|\|\|\|\|\|#\|\|\|+\|\|\| +\| +\| \|++ \|\| ++ Sbjct 269 AYSVTGADQVEYRGEAVQLVRIRNPWGQVE#WNGAWSDDSSEWRYVSSDDRERLTNR 324
Xenopus laevis	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|+\| \| \| \|+\|+\|\|\|\|+\|+\|\|\|\|\|\|\|\|#\|\|\|+\|\|\| +\|+ + \|\| \|\| +\| Sbjct 255 AYSITATDVVNFQGQKVKLIRIRNPWGQVE#WNGAWSDNSSEWNIIGAAEKNRLSQASLDD 314
Xenopus tropicalis	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQ 342 \|\|\|\|\|\| +\|\|\|++\| + \|\|+\|+\|\|\|\|\|+\|\|#\| \| \|\|\| +\|+++\| \|\| \| \| Sbjct 264 AYSVTGAEEVLYRGRQEKLIRVRNPWGEVE#WTGPWSDTAPEWNYIDPKVKAALDKQ 319
Caenorhabditis elegans	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTED 346 \|\|\|\|\|\|+ \| \|\|\| \|+\|+\|\|\|\|\| \|#\|\|\| \|\|\|+ \| \|\|++++ +++ ++ \|\| Sbjct 370 AYSVTGVHTVETDKEKVALLRIRNPWGDTE#WNGDWSDKSSLWEQVDQEQREKMEFRIKED 429
Pongo pygmaeus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQ 340 \|\|\|\|\|\| +\| ++\|+ \| \|+\|+\|\|\|\|\|+\|\|#\| \|+\|\|\| +\|+ \|\| \|+ +\|+ Sbjct 273 AYSVTGAKQVNYRGQMVSLIRMRNPWGEVE#WTGAWSDSSSEWNNVDPYERDQLR 326
synthetic construct	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQ 340 \|\|\|\|\|\| +\| ++\|+ \| \|+\|+\|\|\|\|\|+\|\|#\| \|+\|\|\| +\|+ \|\| \|+ +\|+ Sbjct 273 AYSVTGAKQVNYRGQVVSLIRMRNPWGEVE#WTGAWSDSSSEWNNVDPYERDQLR 326
catalytic	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARL 339 \|\|\|\|\|\| +\|\| \| \|\|+\|+\|\|\|\|\|+\|\|#\| \| \|+\| \|+ +\| +\|+ \|\| Sbjct 292 AYSVTGAEEVESNGSLQKLIRIRNPWGEVE#WTGRWNDNCPSWNTIDPEERERL 344
Coturnix coturnix	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQVTE 345 \|\|\|\|\| +\| ++\|++ +\|+\|+\|\|\|\|\|\|\|\|#\| \|+\|\|\| +\| +\| ++ \|\| ++ + Sbjct 266 AYSVTAFKDVNYRGQQEQLIRIRNPWGQVE#WTGAWSDGSPEWDNIDPSDREELQQKMED 324
Stizostedion vitreum vitreum	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQHQ 342 \|\|\|\|\|\| +\| +\| \|\|+\|+\|\|\|\|\|\|\|\|#\| \|+\|\|\| \| + +++ \|\| \|+ Sbjct 264 AYSVTGTAQVEHQGGTEKLIRIRNPWGQVE#WTGAWSDNSMQWRRISSEDRERLSHR 319
Bos grunniens	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARLQ 340 \|\|\|\|\|\| +\| ++\|+ \| \|+\|+\|\|\|\|\|+\|\|#\| \|+\|\|\| +\|+ \|\| + +\|+ Sbjct 237 AYSVTGAKQVNYQGQMVNLIRMRNPWGEVE#WTGAWSDGSSEWNGVDPYMREQLR 290
Strongylocentrotus purpuratus	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARL 339 \|\|++\| + +\| \|\| \|+\|+\|+\|\|\|\|\| \|\|#\|\|\| \|\|\| ++\| +++ \|+ \| Sbjct 236 AYTITDVKKVNVKGRDVRLIRIRNPWGAVE#WNGRWSDNAREWDDINQRERKNL 288
Tribolium castaneum	Query 287 AYSVTGLDEVLFKGEKVKLVRLRNPWGQVE#WNGSWSDRWKDWSFVDKDEKARL 339 \|\|\|+\|\|\| \| + \|+\|+\|\|\|\|\| \|\|#\|\|\| \|\|\| \|\| \| \|+ \| +\| Sbjct 282 AYSITGLYTSQLKNVTIHLIRVRNPWGSVE#WNGPWSDNSVCWSLVPKETKQKL 334

[Site 2] KDEKARLQHQ³⁴²-VTEDGEFWMS

Gln³⁴² Val

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Lys³³³	Asp³³⁴	Glu³³⁵	Lys³³⁶	Ala³³⁷	Arg³³⁸	Leu³³⁹	Gln³⁴⁰	His³⁴¹	Gln³⁴²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Val³⁴³	Thr³⁴⁴	Glu³⁴⁵	Asp³⁴⁶	Gly³⁴⁷	Glu³⁴⁸	Phe³⁴⁹	Trp³⁵⁰	Met³⁵¹	Ser³⁵²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	137.00	38	hCG40434, isoform CRA_d
2	Pan troglodytes	137.00	11	PREDICTED: similar to Calpain-3 (Calpain L3) (Calp
3	N/A	134.00	20	-
4	Macaca mulatta	134.00	4	PREDICTED: calpain 3
5	Sus scrofa	134.00	4	calpain 3
6	Macaca fascicularis	134.00	1	CAN3_MACFA Calpain-3 (Calpain L3) (Calpain p94) (C
7	Mus musculus	133.00	33	calpain 3
8	Rattus norvegicus	133.00	16	AF184950_1 calpain Rt90
9	Bos taurus	132.00	10	calpain 3
10	Ovis aries	132.00	2	skeletal muscle-specific calpain
11	Oryctolagus cuniculus	131.00	1	calpain 3, (p94)
12	Canis familiaris	130.00	22	PREDICTED: similar to Calpain-3 (Calpain L3) (Calp
13	Monodelphis domestica	123.00	5	PREDICTED: similar to ZP1-related protein
14	Gallus gallus	102.00	7	calpain 3, (p94)
15	Danio rerio	90.50	21	calpain 3, (p94)
16	Tetraodon nigroviridis	86.30	5	unnamed protein product
17	Oncorhynchus mykiss	85.10	3	calpain 1 catalytic subunit
18	Xenopus laevis	84.70	9	MGC83034 protein
19	Stizostedion vitreum vitreum	80.50	1	putative calpain-like protein
20	Xenopus tropicalis	78.20	5	CAPN2 protein
21	Coturnix coturnix	77.80	1	quail calpain
22	Caenorhabditis elegans	77.00	4	CaLPain family member (clp-4)
23	catalytic	77.00	1	Calpain 2, large
24	Pongo pygmaeus	77.00	1	CAN1_PONPY Calpain-1 catalytic subunit (Calpain-1
25	synthetic construct	77.00	1	Homo sapiens calpain 1, (mu/I) large subunit
26	Bos grunniens	74.70	2	calpain 2
27	Drosophila melanogaster	74.30	7	CAA55297.1
28	Caenorhabditis briggsae	74.30	2	Hypothetical protein CBG15134
29	Aedes aegypti	73.60	3	calpain, putative
30	Bos taurus x Bos indicus	72.80	1	micromolar calcium activated neutral protease 1
31	Schistosoma japonicum	71.60	1	SJCHGC01809 protein
32	Anopheles gambiae	71.60	1	calpain
33	Anopheles gambiae str. PEST	71.60	1	ENSANGP00000032073
34	Homarus americanus	71.20	1	muscle-specific calpain
35	Tribolium castaneum	70.90	1	PREDICTED: similar to CG8107-PA
36	Gecarcinus lateralis	70.50	2	muscle-specific calpain
37	Drosophila pseudoobscura	68.20	1	GA20829-PA

Top-ranked sequences

organism	matching
Homo sapiens	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372
Pan troglodytes	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372
N/A	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 84 GQVEWNGSWSDSWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYDDFIYHFTKLEICNLTADA 143
Macaca mulatta	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 361 GQVEWNGSWSDGWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
Sus scrofa	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 361 GQVEWNGSWSDSWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYDDFIYHFTKLEICNLTADA 420
Macaca fascicularis	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 361 GQVEWNGSWSDGWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
Mus musculus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 341 GQVEWNGSWSDGWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYDDFVYHFTKLEICNLTADA 400
Rattus norvegicus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 341 GQVEWNGSWSDGWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYDDFVYHFTKLEICNLTADA 400
Bos taurus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 362 GQVEWNGSWSDSWKDWSYVDKDEKARLQHQ#VTEDGEFWMSYDDFIYHFTKLEICNLTADA 421
Ovis aries	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 362 GQVEWNGSWSDSWKDWSYVDKDEKARLQHQ#VTEDGEFWMSYDDFIYHFTKLEICNLTADA 421
Oryctolagus cuniculus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|++\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 293 GQVEWNGSWSDGWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYDDFVFHFTKLEICNLTADA 352
Canis familiaris	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 318 GQVEWNGSWSDGWKDWSFVDKAEKARLQHQ#VTEDGEFWMSYDDFIYHFTKLEICNLTADA 377
Monodelphis domestica	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\| +\|\|+\|\|+\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 332 GQVEWNGSWSDGWKDWVLIDKEEKSRLQHQ#VTEDGEFWMSYEDFMYNFTKLEICNLTADA 391
Gallus gallus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 \|\|\|\|\|\|\| \|\|\|+ ++\|+\|+\|++\|\| \|\|\|\|+#+ \|\|\|\|\|\|+\| \|\|\|+ \|\|\|\|\|\|\|\|\|\|\| \| Sbjct 354 GQVEWNGPWSDKSEEWNFIDEEEKIRLQHK#IAEDGEFWISLEDFMRHFTKLEICNLTPD 412
Danio rerio	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\| \|\|\| \|+\| + \| \|\| +\|\| \|# \|\|\|\|\|\|\|\|+\|\|\| ++\|\|+\|\|\|\|\|\| \|\| Sbjct 297 GQVEWNGPWSDNSKEWESLSKAEKEKLQQQ#NAEDGEFWMSFEDFKKNYTKIEICNLTPDA 356
Tetraodon nigroviridis	Query 313 GQVEWNGSWSDR----------WKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTK 362 \|\|\|\|\|\|\| \|\|\|+ \|+\|\| + \| \|\| +\| \|\|# \|\|\|\|\|\|\|\|+\|\|\| ++\|\| Sbjct 297 GQVEWNGPWSDKNRPFRLLRNSSKEWSTLSKAEKEKLHHQ#SAEDGEFWMSFEDFKKNYTK 356 Query 363 LEICNLTADA 372 +\|\|\|\|\|\| \|\| Sbjct 357 IEICNLTPDA 366
Oncorhynchus mykiss	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|++\|\| \|+\|\|\| ++\| \|\|+ + \|\|\|++# +\|\|\|\|\|\|\|\|+ \|\|+ \|\|+\|\|\|\|\|\|\|\|\|\| Sbjct 294 GEIEWTGAWSDNSREWESVDRSVRGRLQNR#-SEDGEFWMSFSDFLREFTRLEICNLTADA 352
Xenopus laevis	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\|\|\|+\|\|\| +\|+ + \|\| \|\| # +\|\|\|\|\|\| +\|\|\| \|\| \|\|\|\|\|\|\|\| \|\| Sbjct 281 GQVEWNGAWSDNSSEWNIIGAAEKNRLSQA#SLDDGEFWMDFEDFKRHFDKLEICNLTPDA 340
Stizostedion vitreum vitreum	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\| \|+\|\|\| \| + +++ \|\| \|+# +\|\|\|\|\|\|\|\|+ \|\|+ \|+ +\|\|\|\|\|\|\| \|\| Sbjct 290 GQVEWTGAWSDNSMQWRRISSEDRERLSHR#-SEDGEFWMSFADFLRHYDRLEICNLTPDA 348
Xenopus tropicalis	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\| \|+\|\|\| +\|+ \|\| \|+ \|\| +#+ \|\|\|\|\|\|\|\|+++\|+ \|++\|\|\|\|\|\|\| \|\| Sbjct 292 GQVEWTGAWSDNSSEWNEVDPSEQEDLQLK#M-EDGEFWMSFQEFLRQFSRLEICNLTPDA 350
Coturnix coturnix	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|\| \|+\|\|\| +\| +\| ++ \|\| +#+ \|\|\|\|\|\|\|\|+ \|\|+ \|++\|\|\|\|\|\|\| \|\| Sbjct 292 GQVEWTGAWSDGSPEWDNIDPSDREELQQK#M-EDGEFWMSFRDFMREFSRLEICNLTPDA 350
Caenorhabditis elegans	Query 316 EWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 \|\|\|\|+\|\|\| +\|\| +\|+ \| ++ \|# \|\|\|\|\|\|\|+\|\|\| +\|\|++\|+\|\|\|\|\|+ Sbjct 483 EWNGAWSDGSSEWSKIDEATKKQIDVQ#FARDGEFWMSFEDFFSNFTQMEVCNLTAE 538
catalytic	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 \|+\|\|\| \| \|+\| \|+ +\| +\|+ \|\| +# \|\|\|\|\|\|\|\|+ \|\|+ \|+++\|\|\|\|\|\|\| \| Sbjct 318 GEVEWTGRWNDNCPSWNTIDPEERERLTRR#-HEDGEFWMSFSDFLRHYSRLEICNLTPD 375
Pongo pygmaeus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|+\|\|\| \|+\|\|\| +\|+ \|\| \|+ +\|+ +#+ \|\|\|\|\|\|\|\|+ \|\|+ \|\|+\|\|\|\|\|\|\| \|\| Sbjct 299 GEVEWTGAWSDSSSEWNNVDPYERDQLRVK#M-EDGEFWMSFRDFMREFTRLEICNLTPDA 357
synthetic construct	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|+\|\|\| \|+\|\|\| +\|+ \|\| \|+ +\|+ +#+ \|\|\|\|\|\|\|\|+ \|\|+ \|\|+\|\|\|\|\|\|\| \|\| Sbjct 299 GEVEWTGAWSDSSSEWNNVDPYERDQLRVK#M-EDGEFWMSFRDFMREFTRLEICNLTPDA 357
Bos grunniens	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 \|+\|\|\| \| \|+\| +\|+ \|\| + + \| \|# \|\|\|\|\|\|\|\|+ \|\|+ \|+++\|\|\|\|\|\|\| \| Sbjct 1 GEVEWTGQWNDNCPNWNTVDPEVRETLTRQ#-HEDGEFWMSFNDFLRHYSRLEICNLTPD 58
Drosophila melanogaster	Query 314 QVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 + \|\|\|\| \|\|\| +\| ++ +++\|\| + # \|\|\|\|\|\|\|++\|\|+ \|\| ++\|\|\|\|\|+ \|+ Sbjct 309 EAEWNGPWSDSSPEWRYIPEEQKAEIGLT#FDRDGEFWMSFQDFLNHFDRVEICNLSPDS 367
Caenorhabditis briggsae	Query 315 VEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 +\|\|\|\|+\|\|\| +\|\| +\|+ \| ++ \|# \|\|\|\|\|\|+++\|\| +\|\|++\|+\|\|\|\|\|+ Sbjct 449 LEWNGAWSDGSMEWSKIDEATKKQIDVQ#FARDGEFWMNFDDFFANFTQMELCNLTAE 505
Aedes aegypti	Query 315 VEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 +\|\|\|\|+\|\|\|\| ++\| + \| ++ +\| #+ \|\|\|\|\|\| +\|\|\|+ +\| ++\|\|\|\|\|+ \| Sbjct 307 IEWNGAWSDRSQEWQAIPKAQRKQLGLT#IDNDGEFWMDFEDFLRYFDRVEICNLSPD 363
Bos taurus x Bos indicus	Query 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 \|+\|\|\| \|+\|\|\| +\|+ \|\| + +\|+ +#+ \|\|\|\|\|\|\|\|+ \|\|+ \|\|+\|\|\|\|\|\|\| \| Sbjct 15 GEVEWTGAWSDGSSEWNGVDPYMREQLRVK#M-EDGEFWMSFRDFMREFTRLEICNLTPD 72
Schistosoma japonicum	Query 316 EWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNL 368 \|\| \|+\|\|\|+ \|+\|\| + +++ +\| # +\|\|\|\|\|\|\|\|+\|\|+ +\| \|\|\|\|\|+\| Sbjct 368 EWKGAWSDKSKEWSLISPEQRQQLGLT#FDDDGEFWMSYQDFVSNFEKLEICHL 420
Anopheles gambiae	Query 314 QVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 + \|\|\|\| \|\|\|+ +\| ++ ++\| \| # \|\|\|\|\|\|\|\| \|\| +\| ++\|\|\|\|\|+ \|+ Sbjct 15 EAEWNGPWSDKSPEWRYIPDEQKQELGLN#FDHDGEFWMSYRDFTRYFDRMEICNLSPDS 73
Anopheles gambiae str. PEST	Query 314 QVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 + \|\|\|\| \|\|\|+ +\| ++ ++\| \| # \|\|\|\|\|\|\|\| \|\| +\| ++\|\|\|\|\|+ \|+ Sbjct 15 EAEWNGPWSDKSPEWRYIPDEQKQELGLN#FDHDGEFWMSYRDFTRYFDRMEICNLSPDS 73
Homarus americanus	Query 314 QVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 + \|\| \|\|\|\|\|+ +\|+ + +\|\| \|\|+ # +\|\|\|\|\|\|\|++\|\| +\|\| +\|\|\|++\| + Sbjct 334 EAEWKGSWSDKSPEWNSITPEEKQRLKLN#FEDDGEFWMSFQDFASNFTTVEICDVTPE 391
Tribolium castaneum	Query 316 EWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|\|\|+\|\|\| +\| ++ +\| \| # \|\|\|\|\|\|\|++\|\| \|\| ++\|\|\|\|\| \|+ Sbjct 701 EWNGAWSDHSPEWHYISDSDKEELGLN#FDADGEFWMSFKDFQQHFNRIEICNLNPDS 757
Gecarcinus lateralis	Query 314 QVEWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTAD 371 + \|\| \|\|\|\|\|+ +\|+ \| \|+ \|\| # +\|\|\|\|\|\|\|\|+\|\|+ +\|\| +\|\|\|++ \| Sbjct 334 ETEWKGSWSDKSPEWNAVPPGERQRLGLT#FNDDGEFWMSYQDFLKNFTTVEICDVNPD 391
Drosophila pseudoobscura	Query 316 EWNGSWSDRWKDWSFVDKDEKARLQHQ#VTEDGEFWMSYEDFIYHFTKLEICNLTADA 372 \|\|+\| \|\|\| +\| \|+ + \| + # \|\|\|\|\|\|\|++\|\|+ \|\| ++\|\|\|\|\| \|+ Sbjct 511 EWSGPWSDSSPEWRFIPEHVKEEIGLN#FDRDGEFWMSFQDFLNHFDRVEICNLNPDS 567

* References

None.