XSB2633 : PREDICTED: similar to glutamate receptor, ionotropic, N-methyl D-aspartate 2A [Equus caballus]
[ CaMP Format ]
This entry is computationally expanded from SB0072
* Basic Information
| Organism | Equus caballus (horse) |
| Protein Names | similar to glutamate receptor; ionotropic; N-methyl D-aspartate 2A |
| Gene Names | LOC100051329; The sequence of the transcript was modified to remove a frameshift represented in this assembly; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 2 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1465 aa
Average Mass: 165.499 kDa
Monoisotopic Mass: 165.394 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| HS1_rep 1. | 179 | 215 | 6.7 | 3.1 |
| Lig_chan-Glu_bd 1. | 437 | 500 | 80.6 | 5.5e-21 |
| Lig_chan 1. | 552 | 839 | 356.4 | 5.5e-104 |
| NMDAR2_C 1. | 840 | 1465 | 1175.2 | 0 |
| --- cleavage 1330 (inside NMDAR2_C 840..1465) --- |
| --- cleavage 1279 (inside NMDAR2_C 840..1465) --- |
3. Sequence Information
Fasta Sequence: XSB2633.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] LEGNLYGSLF1330-SVPSNKLSGN
Phe1330 
Ser
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Leu1321 | Glu1322 | Gly1323 | Asn1324 | Leu1325 | Tyr1326 | Gly1327 | Ser1328 | Leu1329 | Phe1330 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser1331 | Val1332 | Pro1333 | Ser1334 | Asn1335 | Lys1336 | Leu1337 | Ser1338 | Gly1339 | Asn1340 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
REIDLSRPSRSISLKDRERLLEGNLYGSLFSVPSNKLSGNKSSLFPQGLEDSKRSQSLLP
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
112.00 |
4 |
1 |
| 2 |
Rattus norvegicus |
112.00 |
4 |
N-methyl-D-aspartate receptor NMDAR2A subunit; NMD |
| 3 |
NMDA |
112.00 |
3 |
NMDE1_RAT Glutamate |
| 4 |
Mus musculus |
112.00 |
2 |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
| 5 |
Canis familiaris |
111.00 |
1 |
PREDICTED: similar to glutamate receptor, ionotrop |
| 6 |
Homo sapiens |
110.00 |
2 |
N-methyl-D-aspartate receptor subunit 2A precursor |
| 7 |
Pan troglodytes |
110.00 |
1 |
N-methyl-D-aspartate receptor subunit 2A |
| 8 |
Saimiri boliviensis |
110.00 |
1 |
glutamate receptor ionotropic N-methyl-D-aspartate |
| 9 |
Bos taurus |
103.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 10 |
Monodelphis domestica |
100.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 11 |
Gallus gallus |
80.90 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 12 |
Danio rerio |
70.10 |
2 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 13 |
Tetraodon nigroviridis |
48.10 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||||||||||||||||||||||||||||#||||+|| |||||||||||||||||+||||
Sbjct 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Rattus norvegicus |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||||||||||||||||||||||||||||#||||+|| |||||||||||||||||+||||
Sbjct 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| NMDA |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||||||||||||||||||||||||||||#||||+|| |||||||||||||||||+||||
Sbjct 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Mus musculus |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||||||||||||||||||||||||||||#||||+|| |||||||||||||||||+||||
Sbjct 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Canis familiaris |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||+|||||||||||||||||||||||||||#||||+|||||||||||||||| |||+||||
Sbjct 1300 REMDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLSGNKSSLFPQGLEDRKRSKSLLP 1359
|
| Homo sapiens |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||+||||||||||||||||||||| |||||#||||+|||| |||||||||||||||+||||
Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
|
| Pan troglodytes |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||+||||||||||||||||||||| |||||#||||+|||| |||||||||||||||+||||
Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
|
| Saimiri boliviensis |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
|||||||||||||||||||||||| |||||#||||+|||| |||||||||||||||+||||
Sbjct 1224 REIDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1283
|
| Bos taurus |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||+| |||||||||||||||||||||||||#||||+||+||| |||||||| |||+||||
Sbjct 1072 REVDPSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLAGNKGSLFPQGLEVGKRSKSLLP 1131
|
| Monodelphis domestica |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||| ||||||||||+|||||||||||||#||||+|| ||| ||| | |||+|||+|| |
Sbjct 1305 REIDLGRPSRSISLKDKERLLEGNLYGSLF#SVPSSKLLGNKGSLFSQALEDTKRSKSLFP 1364
|
| Gallus gallus |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
||||| ||||||||||+|+ |+ + | |+|#||||+|| ||+|| |||||||+|| |
Sbjct 1294 REIDLGRPSRSISLKDKEKFLQSSPYASMF#SVPSSKLLSNKASLLTHALEDSKRSKSLYP 1353
|
| Danio rerio |
Query 1301 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSNKLSGNKSSLFPQGLEDSKRSQSLLP 1360
+||||+||+||+|||+++| || + | ++|#++ ++|| |++| || + ||+||||+|| |
Sbjct 1289 KEIDLNRPARSVSLKEKDRFLEDSPYANMF#NIKADKLFGSRSMLFNRNLEESKRSKSLYP 1348
|
| Tetraodon nigroviridis |
Query 1301 REIDLSRPSRSISLKDRERLLEGNL-YGSLF#SVP--SNKLSG--NKSSLFPQGLEDSKRS 1355
+++|+ ||+||+|||+++| + | +||#++ | +| | +|| +| ||+||||
Sbjct 1216 KDVDVGRPARSVSLKEKDRFATSDSHYANLF#NMRPYSGRLFGTSSKSMMFNHNLEESKRS 1275
Query 1356 QSLLP 1360
+|| |
Sbjct 1276 KSLYP 1280
|
[Site 2] QDWAQNNALQ1279-FQKNKLRISR
Gln1279 Phe
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Gln1270 | Asp1271 | Trp1272 | Ala1273 | Gln1274 | Asn1275 | Asn1276 | Ala1277 | Leu1278 | Gln1279 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Phe1280 | Gln1281 | Lys1282 | Asn1283 | Lys1284 | Leu1285 | Arg1286 | Ile1287 | Ser1288 | Arg1289 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
DEDQMLQETGNPATQEEVYQQDWAQNNALQFQKNKLRISRQHSYDNILDKPREIDLSRPS
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
NMDA |
122.00 |
6 |
NMDE1_RAT Glutamate |
| 2 |
Rattus norvegicus |
122.00 |
4 |
glutamate receptor, ionotropic, N-methyl D-asparta |
| 3 |
Saimiri boliviensis |
120.00 |
1 |
glutamate receptor ionotropic N-methyl-D-aspartate |
| 4 |
N/A |
119.00 |
5 |
2 |
| 5 |
Mus musculus |
119.00 |
2 |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
| 6 |
Homo sapiens |
118.00 |
4 |
N-methyl-D-aspartate receptor subunit 2A precursor |
| 7 |
Pan troglodytes |
118.00 |
2 |
N-methyl-D-aspartate receptor subunit 2A |
| 8 |
Canis familiaris |
116.00 |
1 |
PREDICTED: similar to glutamate receptor, ionotrop |
| 9 |
Bos taurus |
114.00 |
2 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 10 |
Monodelphis domestica |
105.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 11 |
Gallus gallus |
87.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 12 |
Danio rerio |
54.70 |
2 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 13 |
Tetraodon nigroviridis |
50.80 |
1 |
unnamed protein product |
| 14 |
Paramecium tetraurelia |
36.60 |
1 |
hypothetical protein |
| 15 |
Macaca mulatta |
34.30 |
1 |
PREDICTED: N-methyl-D-aspartate receptor subunit 2 |
| 16 |
Canis lupus familiaris |
33.90 |
1 |
N-methyl-D-aspartate receptor subunit 2B |
Top-ranked sequences
| organism | matching |
|---|
| NMDA |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||||||+||||||||+||||||#||||||||+|||||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
|
| Rattus norvegicus |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||||||+||||||||+||||||#||||||||+|||||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
|
| Saimiri boliviensis |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||||||+|+|||||||||||||# ||||||||||||||||+||||||||||||
Sbjct 1173 DEDQMLQETGNPATREQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPREIDLSRPS 1232
|
| N/A |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
|||||||||||||| |||||||||||||||# ||||||||||||||||+|||||+||||||
Sbjct 1249 DEDQMLQETGNPATGEEVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
|
| Mus musculus |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||||||+|| |||||+||||||#||||||+|+|||||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQHSYDNILDKPREIDLSRPS 1308
|
| Homo sapiens |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
|||||||||||||| |+|||||||||||||# ||||||||||||||||+|||||+||||||
Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
|
| Pan troglodytes |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
|||||||||||||| |+|||||||||||||# ||||||||||||||||+|||||+||||||
Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
|
| Canis familiaris |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||+|| ||||||||||||+ ||#|||||||||||||||||+|||||+||||||
Sbjct 1249 DEDQMLQETGSPAAQEEVYQQDWAQNSTLQ#FQKNKLRISRQHSYDNIVDKPREMDLSRPS 1308
|
| Bos taurus |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPREIDLSRPS 1309
||||||||||||| |||||||||| |+|||# ||||||||||||||||||||||+| ||||
Sbjct 1021 DEDQMLQETGNPAAQEEVYQQDWAPNSALQ#LQKNKLRISRQHSYDNILDKPREVDPSRPS 1080
|
| Monodelphis domestica |
Query 1250 DEDQMLQET-GNPATQEEVYQQDWAQNNALQ#FQK-NKLRISRQHSYDNILDKPREIDLSR 1307
||||||||| ||| || |+||||||||||#||| ||||||||||||||||||||||| |
Sbjct 1252 DEDQMLQETTANPAHPEETYEQDWAQNNALQ#FQKKNKLRISRQHSYDNILDKPREIDLGR 1311
Query 1308 PS 1309
||
Query 1308 PS 1309
|
| Gallus gallus |
Query 1250 DEDQMLQETGNPATQEEVYQQDWAQNNALQ#F-QKNKLRISRQHSYDNILDKPREIDLSRP 1308
+||||||+| | + ||+| |+||||||#+ +|||||||||||+||| || ||||| ||
Sbjct 1242 EEDQMLQDTTNLSLPEEIYGHSWSQNNALQ#YHKKNKLRISRQHSFDNIADKSREIDLGRP 1301
Query 1309 S 1309
|
Query 1309 S 1309
|
| Danio rerio |
Query 1251 EDQMLQETG-NPATQ-EEVYQQDWAQNNALQ#FQK-NKLRISRQHSYDNI-LDKPREIDLS 1306
||||||| +|+ ++++ | | + # |+ |+|++|||||+||| |+||+||||+
Sbjct 1235 EDQMLQEAMISPSMHHDDMFSHYWPQTDGPH#VQRRNRLKLSRQHSFDNIMLEKPKEIDLN 1294
Query 1307 RPS 1309
||+
Sbjct 1295 RPA 1297
|
| Tetraodon nigroviridis |
Query 1250 DEDQMLQET-GNPATQEEVYQQD-------WAQNNALQ#FQK-NKLRISRQHSYDNI-LDK 1299
+|||+| + |+| + || | | + # || |+||+|||||+||| |+|
Sbjct 1155 NEDQLLTDPLGSPTLHHQQQQQADEMFGLYWPQTDGPH#VQKRNRLRLSRQHSFDNIMLEK 1214
Query 1300 PREIDLSRPS 1309
|+++|+ ||+
Sbjct 1215 PKDVDVGRPA 1224
|
| Paramecium tetraurelia |
Query 1252 DQMLQETGNPATQEEVYQQDWAQNNALQ#FQKNKLRISR---QHSYDNILDKPREIDLSR 1307
+|| +| +| |+||+ | |#+|| | |||| + || | ||+ ++|
Sbjct 280 NQMNSGKTSPKKEESVHQQNEVDNCLYQ#YQKEKQRISRVDKANYKQNIKDSQREVFIAR 338
|
| Macaca mulatta |
Query 1251 EDQMLQETGNPATQEEV--------YQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPRE 1302
|| ||| || | | | + | +# +|||| |||||| +| +|
Sbjct 1256 EDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQK#KNRNKLR--RQHSYDTFVDLQKE 1313
|
| Canis lupus familiaris |
Query 1251 EDQMLQETGNPATQEEV--------YQQDWAQNNALQ#FQKNKLRISRQHSYDNILDKPRE 1302
|| ||| || | | | + | +# +|||| |||||| +| +|
Sbjct 1256 EDNSLQELDQPAAPVAVPSNAPSTKYPQSPTNSKAQK#KTRNKLR--RQHSYDTFVDLQKE 1313
|
