logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2700 : Chain A, Complex Between Rabbit Muscle Alpha-Actin: Human Gelsolin Domain 1

[ CaMP Format ]

This entry is computationally expanded from SB0071

* Basic Information

OrganismOryctolagus cuniculus (rabbit)
Protein NamesActin, alpha skeletal muscle; Alpha-actin-1
Gene NamesACTA
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1EQY_A N/A N/A ACTS_RABIT N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 377 aa

Average Mass: 0.000 kDa

Monoisotopic Mass: 0.000 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Actin 1. 4377831.55.2e-247
--- cleavage 39 (inside Actin 4..377) ---

3. Sequence Information

Fasta Sequence: XSB2700.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ALM (Model; -; V/W/X/Y/Z=3-374), 1ATN (X-ray; 280 A; A=3-374), 1EQY (X-ray; 230 A; A=1-377), 1ESV (X-ray; 200 A; A=1-377), 1H1V (X-ray; 299 A; A=3-377), 1IJJ (X-ray; 285 A; A/B=1-377), 1J6Z (X-ray; 154 A; A=4-377), 1KXP (X-ray; 210 A; A=3-377), 1LCU (X-ray; 350 A; A/B=7-377), 1LOT (X-ray; 250 A; B=3-377), 1M8Q (EM; 7000 A; 0/1/2/3/4/5/7/8/9/V/W/X/Y/Z=3-377), 1MA9 (X-ray; 240 A; B=8-372), 1MVW (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1NWK (X-ray; 185 A; A=3-377), 1O18 (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1O19 (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1O1A (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1O1B (EM; 7000 A; 0/1/2/3/4/5/7/8/9/V/W/X/Y/Z=3-377), 1O1C (EM; 7000 A; 0/1/2/3/4/5/7/8/9/V/W/X/Y/Z=3-377), 1O1D (EM; 7000 A; 0/1/2/3/4/5/7/8/9/V/W/X/Y/Z=3-377), 1O1E (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1O1F (EM; 7000 A; 0/1/2/3/4/5/6/7/8/V/W/X/Y/Z=3-377), 1O1G (EM; 7000 A; 1/2/3/4/5/6/7/8/9/V/W/X/Y/Z=3-377), 1P8Z (X-ray; 260 A; A=1-377), 1QZ5 (X-ray; 145 A; A=3-377), 1QZ6 (X-ray; 160 A; A=3-377), 1RDW (X-ray; 230 A; X=3-377), 1RFQ (X-ray; 300 A; A/B=3-377), 1RGI (X-ray; 300 A; A=1-377), 1S22 (X-ray; 160 A; A=3-375), 1SQK (X-ray; 250 A; A=1-377), 1T44 (X-ray; 200 A; A=8-377), 1UY5 (Model; -; A=3-374), 1WUA (X-ray; 145 A; A=3-377), 1Y64 (X-ray; 305 A; A=3-377), 1YXQ (X-ray; 201 A; A/B=3-377), 2A3Z (X-ray; 208 A; A=3-377), 2A40 (X-ray; 180 A; A/D=3-377), 2A41 (X-ray; 260 A; A=3-377), 2A42 (X-ray; 185 A; A=3-377), 2A5X (X-ray; 249 A; A=3-377), 2ASM (X-ray; 160 A; A=3-377), 2ASO (X-ray; 170 A; A=3-377), 2ASP (X-ray; 164 A; A=3-377), 2D1K (X-ray; 250 A; A=3-377), 2FF3 (X-ray; 200 A; B=3-377), 2FF6 (X-ray; 205 A; A=3-377), 2FXU (X-ray; 135 A; A=3-377), 2GWJ (X-ray; 190 A; A=7-377), 2GWK (X-ray; 200 A; A/B=7-377), 2HMP (X-ray; 190 A; A/B=3-377), 2PAV (X-ray; 180 A; A=3-377), 2PBD (X-ray; 150 A; A=1-377), 2Q0R (X-ray; 170 A; A=3-377), 2Q0U (X-ray; 145 A; A=3-377), 2Q1N (X-ray; 270 A; A/B=3-377), 2Q31 (X-ray; 270 A; A/B=3-377), 2Q36 (X-ray; 250 A; A=3-377), 2Q97 (X-ray; 250 A; A=3-377), 2V51 (X-ray; 235 A; B/D=1-377), 2V52 (X-ray; 145 A; B=1-377), 2VCP (X-ray; 320 A; A/B=3-377), 2VYP (X-ray; 235 A; A/B=1-377), 2ZWH (Fiber; 330 A; A=3-377), 3B5U (EM; -; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-377), 3BUZ (X-ray; 281 A; B=3-377), 3CJB (X-ray; 321 A; A=1-377), 3CJC (X-ray; 390 A; A=1-377), 3DAW (X-ray; 255 A; A=1-377)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] RAVFPSIVGR39-PRHQGVMVGM

Arg39 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg30Ala31Val32Phe33Pro34Ser35Ile36Val37Gly38Arg39
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro40Arg41His42Gln43Gly44Val45Met46Val47Gly48Met49

Sequence conservation (by blast)

* References

[PubMed ID: 8395021] McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature. 1993 Aug 19;364(6439):685-92.