XSB2819 : mutant myocilin [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0099
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | mutant myocilin |
| Gene Names | MYOC |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 504 aa
Average Mass: 56.988 kDa
Monoisotopic Mass: 56.953 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| M 1. | 133 | 153 | 8.9 | 9.7 |
| M 2. | 154 | 174 | 4.3 | 40 |
| --- cleavage 226 --- |
| OLF 1. | 246 | 503 | 488.6 | 8.8e-144 |
3. Sequence Information
Fasta Sequence: XSB2819.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] SELTEVPASR226-ILKESPSGYL
Arg226 
Ile
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Ser217 | Glu218 | Leu219 | Thr220 | Glu221 | Val222 | Pro223 | Ala224 | Ser225 | Arg226 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ile227 | Leu228 | Lys229 | Glu230 | Ser231 | Pro232 | Ser233 | Gly234 | Tyr235 | Leu236 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
PGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLT
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
125.00 |
3 |
myocilin |
| 2 |
Pan troglodytes |
124.00 |
1 |
PREDICTED: myocilin |
| 3 |
Macaca fascicularis |
117.00 |
1 |
MYOC_MACFA Myocilin precursor (Trabecular meshwork |
| 4 |
Macaca mulatta |
116.00 |
1 |
PREDICTED: myocilin |
| 5 |
Mus musculus |
105.00 |
4 |
unnamed protein product |
| 6 |
Canis familiaris |
104.00 |
1 |
MYOC_CANFA Myocilin precursor gb |
| 7 |
Felis catus |
104.00 |
1 |
MYOC_FELCA Myocilin precursor gb |
| 8 |
Canis lupus familiaris |
104.00 |
1 |
myocilin |
| 9 |
Bos taurus |
99.40 |
3 |
MYOC_BOVIN Myocilin precursor (Trabecular meshwork |
| 10 |
Oryctolagus cuniculus |
98.20 |
1 |
myocilin |
| 11 |
Rattus norvegicus |
96.30 |
3 |
myocilin |
| 12 |
Sus scrofa |
94.00 |
1 |
myocilin |
| 13 |
Monodelphis domestica |
73.90 |
1 |
PREDICTED: similar to myocilin |
| 14 |
Gallus gallus |
64.30 |
1 |
PREDICTED: similar to myocilin |
| 15 |
Tetraodon nigroviridis |
43.10 |
2 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|
| Pan troglodytes |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||||||||||||||||||||||| ||#||||||||||||||||||||||||||||||
Sbjct 183 PGSREVSTWNLDTLAFQELKSELTEVPVSR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 242
|
| Macaca fascicularis |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||||||||||||||||||||||||||#||||||||+|+| ||| |||||||||||||
Sbjct 184 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGHLQSREGDNGCGELVWVGEPLT 243
|
| Macaca mulatta |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||||||||||||||||||||||||||#||||+|||+|+| ||| |||||||||||||
Sbjct 184 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKENPSGHLQSREGDNGCGELVWVGEPLT 243
|
| Mus musculus |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||| |||||||||||||||||||||+#||||+||| || ||| ||| |||||||+|
Sbjct 183 PGSREVSQWNLDTLAFQELKSELTEVPASQ#ILKENPSGRPRSKEGDKGCGALVWVGEPVT 242
|
| Canis familiaris |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||||| ||++|+ |||||||||||||||#||||||||+ |+ |||+|||||||||||||
Sbjct 177 GSREVSKWNVETVNFQELKSELTEVPASR#ILKESPSGHPRNEEGDSGCGELVWVGEPLT 235
|
| Felis catus |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||||| ||++|+ |||||||||||||||#||||||||+ || ||| |||||||||||||
Sbjct 184 GSREVSKWNVETVNFQELKSELTEVPASR#ILKESPSGHPRSEEGDPGCGELVWVGEPLT 242
|
| Canis lupus familiaris |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||||| ||++|+ |||||||||||||||#||||||||+ |+ |||+|||||||||||||
Sbjct 177 GSREVSKWNVETVNFQELKSELTEVPASR#ILKESPSGHPRNEEGDSGCGELVWVGEPLT 235
|
| Bos taurus |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||||+ |||+ + ||||||||||||||+#||||||||+ |+ || ||||||||||||+|
Sbjct 184 GSREVAKWNLENMDFQELKSELTEVPASQ#ILKESPSGHPRNEEGGTGCGELVWVGEPIT 242
|
| Oryctolagus cuniculus |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||| | ||||||||||||||||||||||#||||+| | ||| |||||||||+|+|
Sbjct 184 GSREASQWNLDTLAFQELKSELTEVPASR#ILKENPPVLPRGEEGDNGCGELVWVGQPVT 242
|
| Rattus norvegicus |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
||||||| |||||||||||||||||||||+#||| + ||+ || ||| ||| |+|||||+|
Sbjct 196 PGSREVSQWNLDTLAFQELKSELTEVPASQ#ILK-NQSGHPRSKEGDKGCGVLMWVGEPVT 254
|
| Sus scrofa |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPLT 256
|||||| ||++ | |||||||||||||+|#||||| ||+ | || +|||||||||||+|
Sbjct 183 GSREVSKWNVENLDFQELKSELTEVPAAR#ILKESVSGHSGSEEGGSGCGELVWVGEPVT 241
|
| Monodelphis domestica |
Query 198 GSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPL 255
||+||| | + | +||||||||||||| #| ||| + + + + |||||||||||+
Sbjct 179 GSKEVSKWGVQKLDYQELKSELTEVPASH#IFKESLTNHSGNKDVGDGCGELVWVGEPI 236
|
| Gallus gallus |
Query 197 PGSREVSTWNLDTLAFQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPL 255
|| + | + | +|||||| ||+||||#+|+|+ | | |+||||| |||||+
Sbjct 8 PGPPAATRWEPEPLGYQELKSERTELPASR#LLEETALG--RPRAEDSGCGELAWVGEPV 64
|
| Tetraodon nigroviridis |
Query 212 FQELKSELTEVPASR#ILKESPSGYLRSGEGDTGCGELVWVGEPL 255
+||+|+||||||||+#++ | | | ||||||+ ||+|+
Sbjct 169 YQEMKAELTEVPASQ#LI---PDGNWTS----TGCGELLSVGDPV 205
|
* References
[PubMed ID: 18776955] Xie X, Zhou X, Qu X, Wen J, Tian Y, Zheng F, Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma. Mol Vis. 2008 Sep 5;14:1666-72.
