XSB2881 : nonerythroid alpha-spectrin
[ CaMP Format ]
This entry is computationally expanded from SB0061
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Spectrin alpha chain, brain; Spectrin, non-erythroid alpha chain; Alpha-II spectrin; Fodrin alpha chain |
| Gene Names | SPTAN1; SPTA2 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2472 aa
Average Mass: 284.282 kDa
Monoisotopic Mass: 284.107 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Spectrin 1. | 44 | 147 | 128.0 | 3.1e-35 |
| Spectrin 2. | 149 | 253 | 140.2 | 6.3e-39 |
| Spectrin 3. | 255 | 359 | 139.5 | 1e-38 |
| Spectrin 4. | 361 | 465 | 115.0 | 2.5e-31 |
| Spectrin 5. | 467 | 571 | 125.2 | 2.2e-34 |
| Spectrin 6. | 573 | 676 | 125.4 | 1.9e-34 |
| Spectrin 7. | 678 | 782 | 146.0 | 1.2e-40 |
| Spectrin 8. | 784 | 888 | 153.3 | 7.5e-43 |
| SH3_1 1. | 970 | 1024 | 78.9 | 1.8e-20 |
| Spectrin 9. | 1091 | 1231 | 71.6 | 2.9e-18 |
| --- cleavage 1176 (inside Spectrin 1091..1231) --- |
| Spectrin 10. | 1233 | 1337 | 148.4 | 2.2e-41 |
| Spectrin 11. | 1339 | 1443 | 119.7 | 9.5e-33 |
| Spectrin 12. | 1445 | 1549 | 127.9 | 3.3e-35 |
| Spectrin 13. | 1551 | 1656 | 98.7 | 2e-26 |
| Spectrin 14. | 1658 | 1762 | 130.4 | 5.7e-36 |
| Spectrin 15. | 1764 | 1868 | 146.8 | 6.5e-41 |
| Spectrin 16. | 1870 | 1974 | 124.8 | 2.8e-34 |
| Spectrin 17. | 1976 | 2081 | 121.0 | 3.8e-33 |
| Spectrin 18. | 2091 | 2195 | 72.2 | 1.9e-18 |
| Spectrin 19. | 2205 | 2310 | 68.7 | 2.1e-17 |
| efhand 1. | 2327 | 2355 | 22.5 | 0.0017 |
| efhand 2. | 2370 | 2398 | 23.4 | 0.00096 |
| efhand_Ca_insen 1. | 2402 | 2471 | 40.9 | 5e-09 |
3. Sequence Information
Fasta Sequence: XSB2881.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB:
2FOT (X-ray; 245 A; C=1172-1210), 3FB2 (X-ray; 230 A; A/B=1337-1544)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VQAVQQQEVY1176-GMMPRDETDS
Tyr1176 
Gly
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val1167 | Gln1168 | Ala1169 | Val1170 | Gln1171 | Gln1172 | Gln1173 | Glu1174 | Val1175 | Tyr1176 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gly1177 | Met1178 | Met1179 | Pro1180 | Arg1181 | Asp1182 | Glu1183 | Thr1184 | Asp1185 | Ser1186 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
95.50 |
16 |
SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, |
| 2 |
N/A |
95.50 |
4 |
- |
| 3 |
Monodelphis domestica |
94.40 |
2 |
PREDICTED: similar to spectrin alpha 2 isoform 2 |
| 4 |
Canis familiaris |
94.40 |
1 |
PREDICTED: similar to Spectrin alpha chain, brain |
| 5 |
Rattus norvegicus |
93.60 |
3 |
alpha-spectrin 2 |
| 6 |
Bos taurus |
91.70 |
2 |
PREDICTED: similar to SPTAN1 protein isoform 2 |
| 7 |
Mus musculus |
91.30 |
19 |
PREDICTED: similar to Spectrin alpha chain, brain |
| 8 |
Gallus gallus |
91.30 |
3 |
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) |
| 9 |
Xenopus tropicalis |
66.60 |
1 |
hypothetical protein LOC100036647 |
| 10 |
Tetraodon nigroviridis |
58.20 |
2 |
unnamed protein product |
| 11 |
Danio rerio |
57.40 |
1 |
alpha II-spectrin |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||||||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
|
| N/A |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||||||||||||||||||||||||||
Sbjct 472 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDETDSKTASPWKSARLMVHTVATFN 531
|
| Monodelphis domestica |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||+|||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1206
|
| Canis familiaris |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||+|||||||||||||||||||||||
Sbjct 1243 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1302
|
| Rattus norvegicus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||| ||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDEADSKTASPWKSARLMVHTVATFN 1206
|
| Bos taurus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| |||||+||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDESDSKTASPWKSARLMVHTVATFN 1206
|
| Mus musculus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||| ||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
|
| Gallus gallus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
|||||||| |||||||| |#|||||||||||| |||||||+|||||||||
Sbjct 1147 LKDINKVANDLESEGLMAEEVQAVEHQEVY#GMMPRDETDSKTVSPWKSARMMVHTVATFN 1206
|
| Xenopus tropicalis |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
||||||||++||||||+ |#|| ||| |||+|||||| | | |||||
Sbjct 1147 LKDINKVADELESEGLITEEVQPVQHQEVY#GMQ-RDEADSKSASPWKSVRTAVLAVATFN 1205
|
| Tetraodon nigroviridis |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMP----RDETDSKTASPWKSARLMVHTV 1202
|+|||||| +||||||| # ++ +|| |||||||||+ || | |
Sbjct 1267 LRDINKVAAELESEGLMAEETPMVQAQQQQ#ELLGAAPGKDEADSKTASPWKNVRLAVQTT 1326
Query 1203 ATFN 1206
| ||
Sbjct 1327 ANFN 1330
|
| Danio rerio |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXX--Y#GMMP-RDETDSKTASPWKSARLMVHTVA 1203
|+|||||| +||||||| #| | +|| ||| |||||| || | | |
Sbjct 1147 LRDINKVASELESEGLMAEEAPVVQAQQVEVL#GSAPGKDEADSKGASPWKSVRLAVQTTA 1206
Query 1204 TFN 1206
||
Sbjct 1207 NFN 1209
|
* References
[PubMed ID: 2307671] Moon RT, McMahon AP, Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. J Biol Chem. 1990 Mar 15;265(8):4427-33.
