CaMPDB :: Substrate

XSB2919 : dystrophin [Homo sapiens]

This entry is computationally expanded from SB0073

* Basic Information

Organism	Homo sapiens (human)
Protein Names	dystrophin
Gene Names	DMD
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
CAI39566	N/A	N/A	DMD_HUMAN	N/A	2928	N/A	hsa:1756

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3685 aa

Average Mass: 426.778 kDa

Monoisotopic Mass: 426.512 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	16	119	108.8	1.9e-29
CH 2.	135	240	100.9	4.3e-27
Spectrin 1.	339	447	79.5	1.2e-20
Spectrin 2.	448	556	69.0	1.8e-17
--- cleavage 690 ---
Spectrin 3.	719	827	11.9	0.0034
Spectrin 4.	830	934	40.6	6.1e-09
Spectrin 5.	943	1045	8.5	0.0065
Spectrin 6.	1048	1154	89.1	1.6e-23
Spectrin 7.	1157	1263	58.9	1.9e-14
Spectrin 8.	1266	1367	16.4	0.0014
DUF1136 1.	1413	1436	-5.0	6.4
Spectrin 9.	1459	1568	0.4	0.031
Spectrin 10.	1571	1676	53.2	1e-12
Spectrin 11.	1679	1779	60.3	7.4e-15
Involucrin 1.	1849	1858	2.3	1.3e
Spectrin 12.	1877	1979	47.1	6.8e-11
--- cleavage 1992 ---
Spectrin 13.	2104	2208	80.2	7.7e-21
Spectrin 14.	2211	2318	63.3	9.2e-16
Involucrin 2.	2330	2339	3.7	58
VitD-bind_III 1.	2390	2451	-24.8	6
Spectrin 15.	2470	2577	20.2	0.00068
Spectrin 16.	2580	2686	57.2	6.4e-14
Spectrin 17.	2689	2802	22.7	0.00042
Spectrin 18.	2934	3040	75.2	2.4e-19
WW 1.	3057	3086	48.9	2e-11
efhand_1 1.	3087	3207	274.7	2.1e-79
efhand_2 1.	3211	3302	230.0	6.1e-66
ZZ 1.	3307	3352	93.3	8.6e-25
M 1.	3501	3521	9.4	8.3
M 2.	3567	3587	5.1	31

3. Sequence Information

Fasta Sequence: XSB2919.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DXX (X-ray; 260 A; A/B/C/D=1-246), 1EG3 (X-ray; 200 A; A=3046-3306), 1EG4 (X-ray; 200 A; A=3046-3306)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] VMETVTTVTT⁶⁹⁰-REQILVKHAQ

Thr⁶⁹⁰ Arg

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val⁶⁸¹	Met⁶⁸²	Glu⁶⁸³	Thr⁶⁸⁴	Val⁶⁸⁵	Thr⁶⁸⁶	Thr⁶⁸⁷	Val⁶⁸⁸	Thr⁶⁸⁹	Thr⁶⁹⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Arg⁶⁹¹	Glu⁶⁹²	Gln⁶⁹³	Ile⁶⁹⁴	Leu⁶⁹⁵	Val⁶⁹⁶	Lys⁶⁹⁷	His⁶⁹⁸	Ala⁶⁹⁹	Gln⁷⁰⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
STAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	55.80	15	unnamed protein product
2	N/A	55.80	3	D
3	Macaca mulatta	55.80	1	PREDICTED: dystrophin, partial
4	Mus musculus	52.80	1	dystrophin, muscular dystrophy
5	Sus scrofa	50.40	1	dystrophin
6	Bos taurus	50.40	1	PREDICTED: similar to dystrophin, partial
7	Canis lupus familiaris	50.10	1	dystrophin
8	Canis familiaris	50.10	1	PREDICTED: hypothetical protein XP_850502
9	Monodelphis domestica	46.60	1	PREDICTED: similar to T cell antigen receptor alph

Top-ranked sequences

organism	matching
Homo sapiens	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|\|\|\|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 661 STAQISQAVTTTQPSLTQTTVMETVTTVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 720
N/A	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|\|\|\|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 661 STAQISQAVTTTQPSLTQTTVMETVTTVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 720
Macaca mulatta	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|\|\|\|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 363 STAQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 422
Mus musculus	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+\|\|\|\|\|\|\| #\|\|\|\|+\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|+ Sbjct 663 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REQIMVKHAQEELPPPPPQKKRQITVDSEL 722
Sus scrofa	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+ \|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 657 SSTQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQIIVDSEI 716
Bos taurus	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+ \|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 57 SSTQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQIIVDSEI 116
Canis lupus familiaris	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+\|\|\|\|\|\|\| #\|\| \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 662 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REHILVKHAQEELPPPPPQKKRQIIVDSEI 721
Canis familiaris	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+\|\|\|\|\|\|\| #\|\| \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 539 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REHILVKHAQEELPPPPPQKKRQIIVDSEI 598
Monodelphis domestica	Query 661 STAQISQAVXXXXXXXXXXXXXXXXXXXXX#REQILVKHAQEELXXXXXQKKRQITVDSEI 720 \|+ \|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|+\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 656 SSVQISQAVTTTQTSLTQTTVMETVTMVTT#REQILVKHAKEEPLPPPPQKKRQIVVDSEI 715

[Site 2] MVMTEDMPLE¹⁹⁹²-ISYVPSTYLT

Glu¹⁹⁹² Ile

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Met¹⁹⁸³	Val¹⁹⁸⁴	Met¹⁹⁸⁵	Thr¹⁹⁸⁶	Glu¹⁹⁸⁷	Asp¹⁹⁸⁸	Met¹⁹⁸⁹	Pro¹⁹⁹⁰	Leu¹⁹⁹¹	Glu¹⁹⁹²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ile¹⁹⁹³	Ser¹⁹⁹⁴	Tyr¹⁹⁹⁵	Val¹⁹⁹⁶	Pro¹⁹⁹⁷	Ser¹⁹⁹⁸	Thr¹⁹⁹⁹	Tyr²⁰⁰⁰	Leu²⁰⁰¹	Thr²⁰⁰²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	120.00	15	unnamed protein product
2	N/A	120.00	2	D
3	Macaca mulatta	118.00	1	PREDICTED: dystrophin, partial
4	Bos taurus	110.00	1	PREDICTED: similar to dystrophin Dp260-1
5	Sus scrofa	109.00	1	dystrophin
6	Canis lupus familiaris	108.00	1	dystrophin
7	Canis familiaris	108.00	1	PREDICTED: hypothetical protein XP_850502
8	Rattus norvegicus	103.00	1	PREDICTED: similar to dystrophin, muscular dystrop
9	Mus musculus	99.40	1	dystrophin, muscular dystrophy
10	Monodelphis domestica	85.50	1	PREDICTED: similar to T cell antigen receptor alph

Top-ranked sequences

organism	matching
Homo sapiens	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022
N/A	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022
Macaca mulatta	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 1665 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 1724
Bos taurus	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|++\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 622 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVLQALSEVEQLLNAPD 681
Sus scrofa	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|++\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 1959 FAHFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSAYLTEITHVSQALSEVEQLLNAPD 2018
Canis lupus familiaris	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|+++ \|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|+\|\|\|\|\|\| Sbjct 1965 FAQFRRLNFAQIHTVHEESVVAMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEELLNAPD 2024
Canis familiaris	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|+++ \|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|+\|\|\|\|\|\| Sbjct 1842 FAQFRRLNFAQIHTVHEESVVAMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEELLNAPD 1901
Rattus norvegicus	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|+\| \|\|\|\|\|\|+#+\|\|\|\|\|\|\|\|\|\|\|+\|+ \|\|\| \|\|\|\|\|\|\|\|\|+ Sbjct 1619 FAQFRRLNFAQIHTLHEETMVVTTEDMPLD#VSYVPSTYLTEISHILQALSEVEQLLNAPE 1678
Mus musculus	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|+\| \|\|\|\|\|\|+#+\|\|\|\|\|\|\|\|\|\|\|+\|+ \|\|\| \|\|+ \|\|\| \|+ Sbjct 1965 FAQFRRLNFAQIHTLHEETMVVTTEDMPLD#VSYVPSTYLTEISHILQALSEVDHLLNTPE 2024
Monodelphis domestica	Query 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022 \|\|\|\|\|\|\|\|+\|\|\| \|\|\|\|\|\| \|\|\|\|\| +\|\|\|# \|\|\|\|\|\|\| \|\| \|+\| + \| \| \|\|\| \|\| Sbjct 1958 FAQFRRLNYAQIQTVREETTMVMTEGLPLE#TLYVPSTYLAEIHRVTQNISEAEFLLNTPD 2017

* References

None.