CaMPDB :: Substrate

XSB2921 : PREDICTED: similar to dystrophin [Equus caballus]

This entry is computationally expanded from SB0073

* Basic Information

Organism	Equus caballus (horse)
Protein Names	similar to dystrophin
Gene Names	LOC100051515; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 6 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_001488174	XM_001488124	100051515	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3715 aa

Average Mass: 428.668 kDa

Monoisotopic Mass: 428.401 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	34	137	109.2	1.4e-29
CH 2.	153	258	102.4	1.6e-27
Spectrin 1.	358	464	37.2	6.4e-08
Spectrin 2.	465	573	61.6	3e-15
--- cleavage 707 ---
Spectrin 3.	736	844	12.1	0.0032
Spectrin 4.	847	951	36.9	8.1e-08
Spectrin 5.	956	1062	19.4	0.00079
Spectrin 6.	1065	1171	85.8	1.5e-22
Spectrin 7.	1174	1280	57.1	6.8e-14
Spectrin 8.	1283	1384	17.3	0.0012
Spectrin 9.	1476	1585	0.4	0.031
Spectrin 10.	1588	1693	52.8	1.3e-12
Spectrin 11.	1696	1796	61.0	4.3e-15
Involucrin 1.	1866	1875	2.3	1.3e
Spectrin 12.	1894	1996	47.7	4.6e-11
--- cleavage 2009 ---
Spectrin 13.	2012	2118	12.1	0.0033
Spectrin 14.	2121	2225	81.6	2.9e-21
Spectrin 15.	2228	2335	55.0	2.8e-13
Spectrin 16.	2338	2432	8.5	0.0065
Spectrin 17.	2480	2587	18.9	0.00087
Spectrin 18.	2590	2696	44.3	4.7e-10
Spectrin 19.	2699	2812	24.7	0.00028
Spectrin 20.	2944	3050	78.1	3.1e-20
WW 1.	3067	3096	48.9	2e-11
efhand_1 1.	3097	3192	164.5	3.1e-46
efhand_2 1.	3196	3287	230.0	6.1e-66
ZZ 1.	3292	3337	93.3	8.6e-25
M 1.	3486	3506	9.4	8.3
M 2.	3552	3572	5.1	31
FGF 1.	3577	3685	-63.8	1.5

3. Sequence Information

Fasta Sequence: XSB2921.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] VMETVTMVTT⁷⁰⁷-REQILVKHAQ

Thr⁷⁰⁷ Arg

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val⁶⁹⁸	Met⁶⁹⁹	Glu⁷⁰⁰	Thr⁷⁰¹	Val⁷⁰²	Thr⁷⁰³	Met⁷⁰⁴	Val⁷⁰⁵	Thr⁷⁰⁶	Thr⁷⁰⁷

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Arg⁷⁰⁸	Glu⁷⁰⁹	Gln⁷¹⁰	Ile⁷¹¹	Leu⁷¹²	Val⁷¹³	Lys⁷¹⁴	His⁷¹⁵	Ala⁷¹⁶	Gln⁷¹⁷

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
SSAQISQAVTTTQPSLTQTTVMETVTMVTTREQILVKHAQEELPPPPPQKKRQIIVDSEI

Summary

#	organism	max score	hits	top seq
1	Canis familiaris	48.10	1	PREDICTED: hypothetical protein XP_850502
2	Canis lupus familiaris	48.10	1	dystrophin
3	Sus scrofa	46.60	1	dystrophin
4	Bos taurus	46.60	1	PREDICTED: similar to dystrophin, partial
5	Homo sapiens	45.10	15	dystrophin
6	N/A	45.10	3	D
7	Macaca mulatta	45.10	1	PREDICTED: dystrophin, partial
8	Mus musculus	44.70	1	dystrophin, muscular dystrophy
9	Monodelphis domestica	42.00	1	PREDICTED: similar to T cell antigen receptor alph
10	Gallus gallus	39.30	1	dystrophin
11	Danio rerio	32.70	1	PREDICTED: dystrophin

Top-ranked sequences

organism	matching
Canis familiaris	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 539 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REHILVKHAQEELPPPPPQKKRQIIVDSEI 598
Canis lupus familiaris	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 662 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REHILVKHAQEELPPPPPQKKRQIIVDSEI 721
Sus scrofa	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\| \|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 657 SSTQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQIIVDSEI 716
Bos taurus	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\| \|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 57 SSTQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQIIVDSEI 116
Homo sapiens	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|+\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 661 STAQISQAVTTTQPSLTQTTVMETVTTVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 720
N/A	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|+\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 661 STAQISQAVTTTQPSLTQTTVMETVTTVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 720
Macaca mulatta	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|+\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\| Sbjct 363 STAQISQAVTTTQPSLTQTTVMETVTMVTT#REQILVKHAQEELPPPPPQKKRQITVDSEI 422
Mus musculus	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\|\|\|\|\|\|\|\| # \|+\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|+ Sbjct 663 SSAQISQAVTTTQPSLTQTTVMETVTMVTT#REQIMVKHAQEELPPPPPQKKRQITVDSEL 722
Monodelphis domestica	Query 678 SSAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \|\| \|\|\|\|\|\| # \|\|\|\|\|\|+\|\| \|\|\|\|\|\|+\|\|\|\|\| Sbjct 656 SSVQISQAVTTTQTSLTQTTVMETVTMVTT#REQILVKHAKEEPLPPPPQKKRQIVVDSEI 715
Gallus gallus	Query 679 SAQISQAVXXXXXXXXXXXXXXXXXXXXX#XXXILVKHAQEELXXXXXQKKRQIIVDSEI 737 \| \|+\|\|\|\| # \|\|\|\|\|\|+\|\|\| \|\|\|\|++\|\|\|\|\| Sbjct 664 SKQVSQAVTTTQTSLTQTTVMETVTMVTT#REQILVKHAKEELPPPPPHKKRQLLVDSEI 722
Danio rerio	Query 712 LVKHAQEELXXXXXQKKRQIIVDSEI 737 +\|\|\| +\| + \|\|\|\|\|\|+\|\|\|\|+ Sbjct 715 MVKHTKEGMSTPPPQKKRQIVVDSEL 740

[Site 2] MVMTEDMPLE²⁰⁰⁹-ISYVPSTYLT

Glu²⁰⁰⁹ Ile

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Met²⁰⁰⁰	Val²⁰⁰¹	Met²⁰⁰²	Thr²⁰⁰³	Glu²⁰⁰⁴	Asp²⁰⁰⁵	Met²⁰⁰⁶	Pro²⁰⁰⁷	Leu²⁰⁰⁸	Glu²⁰⁰⁹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ile²⁰¹⁰	Ser²⁰¹¹	Tyr²⁰¹²	Val²⁰¹³	Pro²⁰¹⁴	Ser²⁰¹⁵	Thr²⁰¹⁶	Tyr²⁰¹⁷	Leu²⁰¹⁸	Thr²⁰¹⁹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
FAQFRRLNFAQIHTVHEESVMVMTEDMPLEISYVPSTYLTEITHVSQALSEVEQLLNAPD

Summary

#	organism	max score	hits	top seq
1	Bos taurus	118.00	1	PREDICTED: similar to dystrophin Dp260-1
2	Sus scrofa	117.00	1	dystrophin
3	Canis familiaris	116.00	1	PREDICTED: hypothetical protein XP_850502
4	Canis lupus familiaris	116.00	1	dystrophin
5	Macaca mulatta	115.00	1	PREDICTED: dystrophin, partial
6	Homo sapiens	113.00	15	dystrophin (muscular dystrophy, Duchenne and Becke
7	N/A	113.00	2	D
8	Rattus norvegicus	106.00	1	PREDICTED: similar to dystrophin, muscular dystrop
9	Mus musculus	101.00	1	dystrophin, muscular dystrophy
10	Monodelphis domestica	84.70	1	PREDICTED: similar to T cell antigen receptor alph
11	Gallus gallus	79.30	1	dystrophin
12	Coxiella burnetii RSA 331	32.30	1	hypothetical protein CburR_01000114

Top-ranked sequences

organism	matching
Bos taurus	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 622 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVLQALSEVEQLLNAPD 681
Sus scrofa	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1959 FAHFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSAYLTEITHVSQALSEVEQLLNAPD 2018
Canis familiaris	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1842 FAQFRRLNFAQIHTVHEESVVAMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEELLNAPD 1901
Canis lupus familiaris	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1965 FAQFRRLNFAQIHTVHEESVVAMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEELLNAPD 2024
Macaca mulatta	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|++\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1665 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 1724
Homo sapiens	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|++\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022
N/A	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|++\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 1963 FAQFRRLNFAQIHTVREETMMVMTEDMPLE#ISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022
Rattus norvegicus	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|+++\| \|\|\|\|\|\|+#+\|\|\|\|\|\|\|\|\|\|\|+\|+ \|\|\|\|\|\|\|\|\|\|\|\|\|+ Sbjct 1619 FAQFRRLNFAQIHTLHEETMVVTTEDMPLD#VSYVPSTYLTEISHILQALSEVEQLLNAPE 1678
Mus musculus	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|+++\| \|\|\|\|\|\|+#+\|\|\|\|\|\|\|\|\|\|\|+\|+ \|\|\|\|\|\|+ \|\|\| \|+ Sbjct 1965 FAQFRRLNFAQIHTLHEETMVVTTEDMPLD#VSYVPSTYLTEISHILQALSEVDHLLNTPE 2024
Monodelphis domestica	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAPD 2039 \|\|\|\|\|\|\|\|+\|\|\| \|\| \|\|+ \|\|\|\|\| +\|\|\|# \|\|\|\|\|\|\| \|\| \|+\| +\|\| \| \|\|\| \|\| Sbjct 1958 FAQFRRLNYAQIQTVREETTMVMTEGLPLE#TLYVPSTYLAEIHRVTQNISEAEFLLNTPD 2017
Gallus gallus	Query 1980 FAQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEITHVSQALSEVEQLLNAP 2038 \|\|\|\|\|\|\|\|+\|\|\| \|\| \|++ \|\|\|\| \| +\|# +\|\|\|\|\|\|\| \|\| + \|\|\|\|\|\|\|+ \|\|+\| Sbjct 1965 FAQFRRLNYAQIQTVLEDTTFVMTESMTVE#TTYVPSTYLAEILQLLQALSEVEERLNSP 2023
Coxiella burnetii RSA 331	Query 1981 AQFRRLNFAQIHTVHEESVMVMTEDMPLE#ISYVPSTYLTEI 2021 +\|+ \|+ ++\| +\| \|++\| +\| \| #+\|\|\| \|\|\| \|+ Sbjct 65 SQWFNLSESEIKPLHALDVLLMRKDPPFN#MSYVYLTYLLEL 105

* References

None.