CaMPDB :: Substrate

XSB2926 : huntingtin [Ovis aries]

This entry is computationally expanded from SB0051

* Basic Information

Organism	Ovis aries (sheep)
Protein Names	huntingtin
Gene Names	LOC100216476; huntingtin
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_001136110	NM_001142638	100216476	B7U9A4_SHEEP	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3127 aa

Average Mass: 343.089 kDa

Monoisotopic Mass: 342.872 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
HEAT 1.	105	141	16.0	0.16
HEAT 2.	186	222	8.3	4.8
HEAT 3.	229	264	22.1	0.0023
HEAT 4.	335	370	5.5	11
DUF801 1.	461	493	1.2	34
--- cleavage 524 ---
DUF801 2.	548	576	8.4	1.8
HEAT 5.	736	768	0.8	39
HEAT 6.	790	826	5.8	9.6
HEAT 7.	890	927	23.1	0.0012
L_biotic_typeA 1.	967	1015	-13.3	1.4
VirD1 1.	1195	1343	-35.9	5.9
DUF1348 1.	1349	1509	-29.0	4.1
Utp13 1.	1550	1646	-63.1	1.2
Inhibitor_I68 1.	1665	1741	-46.9	9.1
PerC 1.	1823	1888	-40.7	5
Corona_5a 1.	1969	2025	-1.6	1.4
Crystallin 1.	2167	2225	-9.3	4.7
SASP 1.	2312	2363	-7.5	1.3
DUF2131 1.	2397	2461	-28.5	9
DUF1072 1.	2484	2521	-9.3	7.3
Acetone_carb_G 1.	2577	2662	-66.3	4.9
VirC1 1.	2745	2955	-62.7	7.8
HEAT 8.	2994	3032	1.0	37

3. Sequence Information

Fasta Sequence: XSB2926.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] DEEDILSRSS⁵²⁴-SQMSAVPSDP

Ser⁵²⁴ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Asp⁵¹⁵	Glu⁵¹⁶	Glu⁵¹⁷	Asp⁵¹⁸	Ile⁵¹⁹	Leu⁵²⁰	Ser⁵²¹	Arg⁵²²	Ser⁵²³	Ser⁵²⁴

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser⁵²⁵	Gln⁵²⁶	Met⁵²⁷	Ser⁵²⁸	Ala⁵²⁹	Val⁵³⁰	Pro⁵³¹	Ser⁵³²	Asp⁵³³	Pro⁵³⁴

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
RQTDSVDLAACDLTSAATDGDEEDILSRSSSQMSAVPSDPAMDLNDGTQASSPISDSSQT

Summary

#	organism	max score	hits	top seq
1	Bos taurus	113.00	1	PREDICTED: similar to huntingtin
2	Homo sapiens	108.00	6	huntingtin
3	Macaca mulatta	108.00	1	PREDICTED: huntingtin
4	Pan troglodytes	108.00	1	PREDICTED: huntingtin
5	N/A	107.00	6	-
6	Mus musculus	107.00	5	huntingtin
7	Rattus norvegicus	107.00	1	PREDICTED: similar to Huntingtin (Huntington disea
8	Sus scrofa	107.00	1	huntingtin
9	Canis familiaris	105.00	1	PREDICTED: similar to Huntingtin (Huntingtons dise
10	Monodelphis domestica	104.00	1	PREDICTED: similar to Huntingtons Disease protein
11	Gallus gallus	99.00	1	PREDICTED: similar to Huntingtons Disease protein
12	Xenopus tropicalis	79.70	1	huntingtin
13	Danio rerio	37.00	1	huntingtin
14	Ashbya gossypii ATCC 10895	33.90	1	AER174Wp
15	Staphylococcus haemolyticus JCSC1435	33.10	1	hypothetical protein SH0326
16	Aedes aegypti	33.10	1	synaptotagmin, putative
17	Staphylococcus aureus	32.30	1	SRAP_STAAU Serine-rich adhesin for platelets precu

Top-ranked sequences

organism	matching
Bos taurus	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 499 QTDAVDLAACDLTSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 557
Homo sapiens	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 508 QADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
Macaca mulatta	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 495 QADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 553
Pan troglodytes	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 508 QADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
N/A	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|+ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 485 QADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 543
Mus musculus	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|+ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 486 QADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Rattus norvegicus	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|+ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 486 QADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Sus scrofa	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\|+ \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 505 QPDSVDLSGCDLSSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPVSDSSQT 563
Canis familiaris	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \| \|\|\|\|\| +\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|#\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 496 QPDSVDLTSCDLASAATDGDEEDILSHSS#SQISAVPSDPAMDLNDGTQASSPVSDSSQT 554
Monodelphis domestica	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \|+\| \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|#\|\|+\|\|\|\|\|\|\|\|+\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 499 QSDPVDLTGCDLTSAATDGDEEDMLSRSS#SQISAVPSDPAVDMNDGTQASSPISDSSQT 557
Gallus gallus	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 \|+\|\|\|\|\|++\|\|\|\|\| \|\|+\|+++\|+\|\|\|\|\|#\|\|+\|\|\| \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 460 QSDSVDLSSCDLTSTATEGEDDDVLSRSS#SQISAVQSDPTMDLNDGTQASSPISDSSQT 518
Xenopus tropicalis	Query 496 QTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDG-TQASSPISDSSQT 554 \|+\|\|\|\|+++ \|\| \| \|+\|\|\|\|\|\|\|\| \|\|#\|\|+\| \| \|\| \|+\|\|+\| \|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 437 QSDSVDISSSDLASTVTEGDEEDILSHSS#SQISTVQSDTNMELNEGTTQASSPVSDSSQT 496
Danio rerio	Query 498 DSVDLAACDL---TSAATDGDEEDILSRSS#SQMSAVPS---DPAMDLND---GTQASSPI 548 \|\|\|\|\|+\| + + \|\|\|\|+\|\|\|\|\|#\| + + \| \| \| \| \| +\|\|\| Sbjct 451 DSVDLSASEQGVGPDTPDEEDEEDMLSRSS#SGGAGLVSTSGDLVTDANQMSAGAVSSSPP 510 Query 549 SDSSQT 554 \|+\|\|\|\| Sbjct 511 SESSQT 516
Ashbya gossypii ATCC 10895	Query 497 TDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLND 540 +\|+ \|\|+\| \|\|+ \|\| \| \| ++ ++#\| \|\|+ \|\| \| \|+\| Sbjct 875 SDASDLSAADLSDAAADLDSAPHIADAA#SDDSALVSDAASGLSD 918
Staphylococcus haemolyticus JCSC1435	Query 497 TDSVDLAACDLTSAATD--GDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 +\|\| + \| \|\|\|+\| \| +\| \|+#\| +++ + \|+\| \|\|+ +\|\|\|+ \| Sbjct 1182 SDSASTSVSDSTSASTSLSGSTSTSVSDST#STSTSLSESTSTSLSDSASASTSLSDSAST 1241 Query 497 TDSVDLAACDLTSAATD--GDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 +\|\| + \| \|\|\|+\| \| +\| \|+#\| +++ + \|+\| \|\|+ +\|\|\|+ \| Sbjct 1758 SDSASTSVSDSTSASTSLSGSTSTSVSDST#STSTSLSESTSTSLSDSASASTSLSDSAST 1817 Query 497 TDSVDLAACDLTSAATD--GDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 554 +\|\| + \| \|\|\|+\| \| +\| \|+#\| +++ + \|+\| \|\|+ +\|\|\|+ \| Sbjct 2226 SDSASTSVSDSTSASTSLSGSTSTSVSDST#STSTSLSESTSTSLSDSASASTSLSDSAST 2285
Aedes aegypti	Query 495 RQTDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQ 543 \| \|\|\|\| \| \| \|\| + + \|\|\|\|\|#\| + \| \|\| \|\| \| \| Sbjct 582 RSRDSVDDATSDKTSTSEGYGGDSTLSRSS#S-IRAAPSPPAADSTTSEQ 629
Staphylococcus aureus	Query 497 TDSVDLAACDLTSAATDGDEEDILSRSS#SQMSAVPSDPAMDLNDGTQASSPISDS 551 +\|\| ++ \| \|\|\|+ \|+ \| \| \|+#\|+ + + ++ +\| \| \| +\| \| Sbjct 2092 SDSTSMSESDSTSASMSQDKSDSTSISN#SESVSTSTSTSLSTSDSTSTSESLSTS 2146

* References

None.