XSB2931 : talin 1 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0081
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | talin 1 |
| Gene Names | Tln1; RP23-195K8.11-001; talin 1 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_035732 | NM_011602 | 21894 | A2AIM8_MOUSE | N/A | N/A | N/A | mmu:21894 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2541 aa
Average Mass: 269.821 kDa
Monoisotopic Mass: 269.653 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| FERM_N 1. | 90 | 199 | 101.2 | 3.5e-27 |
| FERM_M 1. | 201 | 313 | 144.7 | 2.8e-40 |
| --- cleavage 433 --- | ||||
| Talin_middle 1. | 491 | 652 | 372.5 | 7.7e-109 |
| Stork_head 1. | 728 | 795 | -14.0 | 3.2 |
| Inhibitor_I34 1. | 840 | 905 | -11.3 | 7.9 |
| CRA_rpt 1. | 907 | 945 | -6.0 | 8.2 |
| CMD 1. | 977 | 1059 | -15.1 | 8.7 |
| DUF1707 1. | 1160 | 1204 | -25.0 | 4.3 |
| XhlA 1. | 1360 | 1411 | -17.3 | 6.8 |
| Mucin 1. | 1476 | 1614 | -38.2 | 9 |
| WSK 1. | 1635 | 1664 | 0.9 | 8 |
| HHH 1. | 1805 | 1834 | 0.1 | 6.9 |
| VBS 1. | 1849 | 1973 | 288.8 | 1.2e-83 |
| Vir_act_alpha_C 1. | 2184 | 2262 | -17.0 | 0.85 |
| Wos2 1. | 2277 | 2322 | -3.6 | 3.1 |
| I_LWEQ 1. | 2341 | 2533 | 372.5 | 7.7e-109 |
3. Sequence Information
Fasta Sequence: XSB2931.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VSPKKSTVLQ433-QQYNRVGKVE
Gln433 
Gln
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val424 | Ser425 | Pro426 | Lys427 | Lys428 | Ser429 | Thr430 | Val431 | Leu432 | Gln433 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln434 | Gln435 | Tyr436 | Asn437 | Arg438 | Val439 | Gly440 | Lys441 | Val442 | Glu443 |
Sequence conservation (by blast)
* References
[PubMed ID: 19363486] Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH, Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol. 2009 May;11(5):624-30. Epub 2009 Apr 12.