XSB2942 : Cellular tumor antigen p53
[ CaMP Format ]
This entry is computationally expanded from SB0053
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13 |
| Gene Names | P53 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 393 aa
Average Mass: 43.712 kDa
Monoisotopic Mass: 43.684 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| P53_TAD 1. | 5 | 29 | 46.4 | 1.1e-10 |
| --- cleavage 25 (inside P53_TAD 5..29) --- | ||||
| P53 1. | 95 | 289 | 511.1 | 1.4e-150 |
| P53_tetramer 1. | 318 | 359 | 85.5 | 1.9e-22 |
3. Sequence Information
Fasta Sequence: XSB2942.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1A1U (NMR; -; A/C=324-358), 1AIE (X-ray; 150 A; A=326-356), 1C26 (X-ray; 170 A; A=325-356), 1DT7 (NMR; -; X/Y=367-388), 1GZH (X-ray; 260 A; A=95-292, C=95-292), 1H26 (X-ray; 224 A; E=376-386), 1HS5 (NMR; -; A/B=324-357), 1JSP (NMR; -; A=367-386), 1KZY (X-ray; 250 A; A/B=95-289), 1MA3 (X-ray; 200 A; B=372-389), 1OLG (NMR; -; A/B/C/D=319-360), 1OLH (NMR; -; A/B/C/D=319-360), 1PES (NMR; -; A/B/C/D=325-355), 1PET (NMR; -; A/B/C/D=325-355), 1SAE (NMR; -; A/B/C/D=319-360), 1SAF (NMR; -; A/B/C/D=319-360), 1SAH (NMR; -; A/B/C/D=319-360), 1SAJ (NMR; -; A/B/C/D=319-360), 1SAK (NMR; -; A/B/C/D=319-360), 1SAL (NMR; -; A/B/C/D=319-360), 1TSR (X-ray; 220 A; A/B/C=94-312), 1TUP (X-ray; 220 A; A/B/C=94-312), 1UOL (X-ray; 190 A; A/B=94-312), 1XQH (X-ray; 175 A; B/F=369-377), 1YC5 (X-ray; 140 A; B=372-389), 1YCQ (X-ray; 230 A; B=13-29), 1YCR (X-ray; 260 A; B=15-29), 1YCS (X-ray; 220 A; A=94-292), 2AC0 (X-ray; 180 A; A/B/C/D=94-293), 2ADY (X-ray; 250 A; A/B=94-293), 2AHI (X-ray; 185 A; A/B/C/D=94-293), 2ATA (X-ray; 220 A; A/B/C/D=94-293), 2B3G (X-ray; 160 A; B=33-60), 2BIM (X-ray; 198 A; A/B=94-312), 2BIN (X-ray; 190 A; A=94-312), 2BIO (X-ray; 190 A; A=94-312), 2BIP (X-ray; 180 A; A=94-312), 2BIQ (X-ray; 180 A; A=94-312), 2F1X (X-ray; 230 A; A/B=360-368), 2FEJ (NMR; -; A=94-297), 2FOJ (X-ray; 160 A; B=363-367), 2FOO (X-ray; 220 A; B=358-363), 2GS0 (NMR; -; B=20-71), 2H1L (X-ray; 316 A; M/N/O/P/Q/R/S/T/U/V/W/X=92-292), 2H2D (X-ray; 170 A; B=372-389), 2H2F (X-ray; 220 A; B=372-389), 2H4F (X-ray; 200 A; D=372-389), 2H4H (X-ray; 199 A; B=372-389), 2H4J (X-ray; 210 A; D=372-389), 2H59 (X-ray; 190 A; D/E=372-389), 2J0Z (NMR; -; A/B/C/D=326-356), 2J10 (NMR; -; A/B/C/D=326-356), 2J11 (NMR; -; A/B/C/D=332-356), 2J1W (X-ray; 180 A; A/B=94-312), 2J1X (X-ray; 165 A; A/B=94-312), 2J1Y (X-ray; 169 A; A/B/C/D=94-293), 2J1Z (X-ray; 180 A; A/B=94-312), 2J20 (X-ray; 180 A; A/B=94-312), 2J21 (X-ray; 160 A; A/B=94-312), 2K8F (NMR; -; B=1-39), 2OCJ (X-ray; 205 A; A/B/C/D=94-312), 2PCX (X-ray; 154 A; A=94-292), 2QVQ (X-ray; 200 A; A=94-289), 2QXA (X-ray; 150 A; A/B/C/D=95-289), 2QXB (X-ray; 250 A; A/B/C/D=95-289), 2QXC (X-ray; 185 A; A/B/C/D=95-289), 2VUK (X-ray; 150 A; A/B=94-312), 2Z5S (X-ray; 230 A; P/Q/R=15-29), 2Z5T (X-ray; 230 A; P/Q/R=15-29), 3D05 (X-ray; 170 A; A=94-293), 3D06 (X-ray; 120 A; A=94-293), 3D07 (X-ray; 220 A; A/B=94-293), 3D08 (X-ray; 140 A; A=94-293), 3D09 (X-ray; 190 A; A=94-293), 3D0A (X-ray; 180 A; A/B/C/D=94-293), 3DAB (X-ray; 190 A; B/D/F/H=15-29), 3DAC (X-ray; 180 A; B/P=17-37), 3SAK (NMR; -; A/B/C/D=319-360)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] QETFSDLWKL25-LPENNVLSPL
Leu25 
Leu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gln16 | Glu17 | Thr18 | Phe19 | Ser20 | Asp21 | Leu22 | Trp23 | Lys24 | Leu25 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu26 | Pro27 | Glu28 | Asn29 | Asn30 | Val31 | Leu32 | Ser33 | Pro34 | Leu35 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 117.00 | 44 | tumor protein p53 (Li-Fraumeni syndrome) |
| 2 | N/A | 117.00 | 14 | - |
| 3 | Pan troglodytes | 117.00 | 5 | PREDICTED: tumor protein p53 isoform 3 |
| 4 | synthetic construct | 117.00 | 3 | tumor protein p53 (Li-Fraumeni syndrome) |
| 5 | Tupaia belangeri chinensis | 117.00 | 1 | P53_TUPGB Cellular tumor antigen p53 (Tumor suppre |
| 6 | Macaca mulatta | 110.00 | 2 | tumor protein p53 |
| 7 | Chlorocebus aethiops | 110.00 | 1 | P53_CERAE Cellular tumor antigen p53 (Tumor suppre |
| 8 | Macaca fascicularis | 108.00 | 1 | P53 |
| 9 | Marmota monax | 89.40 | 1 | P53_MARMO Cellular tumor antigen p53 (Tumor suppre |
| 10 | Spalax judaei | 83.60 | 1 | p53 protein |
| 11 | Cavia porcellus | 82.40 | 1 | P53_CAVPO Cellular tumor antigen p53 (Tumor suppre |
| 12 | Delphinapterus leucas | 80.50 | 1 | P53_DELLE Cellular tumor antigen p53 (Tumor suppre |
| 13 | Meriones unguiculatus | 72.40 | 1 | p53 |
| 14 | Oryctolagus cuniculus | 71.20 | 1 | tumor protein p53 |
| 15 | Cricetulus griseus | 69.70 | 2 | p53 tumour suppressor |
| 16 | Mesocricetus auratus | 69.70 | 1 | tumor supressor p53 |
| 17 | Sus scrofa | 68.20 | 3 | tumor suppressor p53 |
| 18 | Ovis aries | 67.80 | 1 | P53 protein |
| 19 | Canis familiaris | 67.80 | 1 | P53 |
| 20 | Felis catus | 66.20 | 2 | tumor protein p53 |
| 21 | Canis lupus familiaris | 65.90 | 1 | tumor protein p53 |
| 22 | Bos taurus | 64.30 | 2 | p53 |
| 23 | Mus musculus | 61.60 | 12 | transformation related protein 53 |
| 24 | Rattus norvegicus | 52.00 | 5 | tumor protein p53 |
| 25 | Bos primigenius | 50.40 | 1 | p53 gene product |
| 26 | Mastomys natalensis | 47.00 | 1 | p53 |
| 27 | Xenopus tropicalis | 44.70 | 1 | tumor protein p53 (Li-Fraumeni syndrome) |
| 28 | Xenopus laevis | 43.50 | 5 | tumor suppressor protein p53 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |
| N/A | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |
| Pan troglodytes | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |
| synthetic construct | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |
| Tupaia belangeri chinensis | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |
| Macaca mulatta | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||+|||||||||||||||#||||||||||||||+|||||||||+ || | Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENNVLSPLPSQAVDDLMLSPDDLAQWLT 55 |
| Chlorocebus aethiops | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||+|||||||||||||||#||||||||||||||+|||||||||+ || | Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENNVLSPLPSQAVDDLMLSPDDLAQWLT 55 |
| Macaca fascicularis | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 |||||||||+|||||||||||||||#||||+|||||||||+|||||||||+ || | Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENHVLSPLPSQAVDDLMLSPDDLAQWLT 55 |
| Marmota monax | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWF 54 ||| ||| |+||||||||||||| |#|||||||||+ | ||||+|| +|+| || Sbjct 1 MEEAQSDLSIEPPLSQETFSDLWNL#LPENNVLSPVLSPPMDDLLLSSEDVENWF 54 |
| Spalax judaei | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLS-PLPSQAMDDLMLSPDDIEQW 53 ||| ||| |+|||||||||||||||#||+||||| || +|+||+|||+|+ | Sbjct 1 MEEQQSDLSIEPPLSQETFSDLWKL#LPQNNVLSTPLSPNSMEDLLLSPEDVANW 54 |
| Cavia porcellus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 |||| || |+|||||||||||||||#|||||||| | || |+|||+++ | Sbjct 1 MEEPHSDLSIEPPLSQETFSDLWKL#LPENNVLSDSLSPPMDHLLLSPEEVASW 53 |
| Delphinapterus leucas | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||| |++ ||||||||||||||||#|||||+|| | |+|||+|||+|+ | Sbjct 1 MEESQAELGVEPPLSQETFSDLWKL#LPENNLLSSELSPAVDDLLLSPEDVANW 53 |
| Meriones unguiculatus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||||||| |+|||||||||||||||#|| |+|| | + |+||+| | |+ | Sbjct 1 MEEPQSDLSIEPPLSQETFSDLWKL#LPPKNLLSAL--EPMEDLLL-PQDVTSW 50 |
| Oryctolagus cuniculus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||| ||| |+|||||||||||||||#|||||+|+ + +||| || +|+ | Sbjct 1 MEESQSDLSLEPPLSQETFSDLWKL#LPENNLLTTSLNPPVDDL-LSAEDVANW 52 |
| Cricetulus griseus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLP-SQAMDDLMLSPDDIEQW 53 ||||||| |+| |||||||||||||#|| ||||| || | ++++| || +++ | Sbjct 1 MEEPQSDLSIELPLSQETFSDLWKL#LPPNNVLSTLPSSDSIEELFLS-ENVTGW 53 |
| Mesocricetus auratus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLP-SQAMDDLMLSPDDIEQW 53 ||||||| |+| |||||||||||||#|| ||||| || | ++++| || +++ | Sbjct 1 MEEPQSDLSIELPLSQETFSDLWKL#LPPNNVLSTLPSSDSIEELFLS-ENVAGW 53 |
| Sus scrofa | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVL-SPLPSQAMDDLMLSP 47 ||| ||+ ||||||||||||||||#|||||+| | | |++||+||| Sbjct 1 MEESQSELGVEPPLSQETFSDLWKL#LPENNLLSSELSLAAVNDLLLSP 48 |
| Ovis aries | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||| |++ |||||||||||||| |#|||||+|| | +|||+ +|+ | Sbjct 1 MEESQAELGVEPPLSQETFSDLWNL#LPENNLLSSELSAPVDDLLPYSEDVVTW 53 |
| Canis familiaris | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 |+||||+ +++|||||||||+|| |#|||||||| |+|+|+| |+ + | Sbjct 1 MQEPQSELNIDPPLSQETFSELWNL#LPENNVLSSELCPAVDELLL-PESVVNW 52 |
| Felis catus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 |+|| + ++||||||||||+|| |#|||||||| | ||++| || +|+ | Sbjct 1 MQEPPLELTIEPPLSQETFSELWNL#LPENNVLSSELSSAMNELPLS-EDVANW 52 |
| Canis lupus familiaris | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||| ||+ +++|||||||||+|| |#|||||||| |+|+|+| |+ + | Sbjct 1 MEESQSELNIDPPLSQETFSELWNL#LPENNVLSSELCPAVDELLL-PESVVNW 52 |
| Bos taurus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||| |++ +|||||||||||||| |#|||||+|| | +||| | |+ | Sbjct 1 MEESQAELNVEPPLSQETFSDLWNL#LPENNLLSSELSAPVDDL-LPYTDVATW 52 |
| Mus musculus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWF 54 ||| ||| |+| |||||||| ||||#|| ++|| ||||+| | |+|++| Sbjct 4 MEESQSDISLELPLSQETFSGLWKL#LPPEDILS--SPHCMDDLLL-PQDVEEFF 54 |
| Rattus norvegicus | Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPS---QAMDDLMLSPDDIE 51 ||+ ||| |+| |||||||| ||||#|| +++| + +|+|| | | | Sbjct 1 MEDSQSDMSIELPLSQETFSCLWKL#LPPDDILPTTATGSPNSMEDLFLPQDVAE 54 |
| Bos primigenius | Query 13 PLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 ||||||||||| |#|||||+|| | +||| | |+ | Sbjct 1 PLSQETFSDLWNL#LPENNLLSSELSAPVDDL-LPYTDVATW 40 |
| Mastomys natalensis | Query 13 PLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPD 48 ||||||| ||||#|| ||| +||++ |||| Sbjct 2 PLSQETFQRLWKL#LPPEAVLSEASPNSMDNMFLSPD 37 |
| Xenopus tropicalis | Query 3 EPQSDPSVEPPLSQETFSDLWKL#LPE 28 || |+ +||||||||| ||| |#||+ Sbjct 2 EPSSETGMEPPLSQETFEDLWSL#LPD 27 |
| Xenopus laevis | Query 3 EPQSDPSVEPPLSQETFSDLWKL#LPE 28 || |+ ++|||||||| ||| |#||+ Sbjct 2 EPSSETGMDPPLSQETFEDLWSL#LPD 27 |
* References
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