XSB2971 : plasma membrane Ca2+ pumping ATPase
[ CaMP Format ]
This entry is computationally expanded from SB0056
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Plasma membrane calcium-transporting ATPase 1; PMCA1; 3.6.3.8; Plasma membrane calcium pump isoform 1; Plasma membrane calcium ATPase isoform 1 |
| Gene Names | ATP2B1; PMCA1 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| AAA74511 | N/A | N/A | AT2B1_HUMAN | N/A | N/A | N/A | hsa:490 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1220 aa
Average Mass: 134.710 kDa
Monoisotopic Mass: 134.625 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| efhand 1. | 13 | 41 | 3.9 | 7.8 |
| Cation_ATPase_N 1. | 44 | 127 | 84.9 | 2.8e-22 |
| E1-E2_ATPase 1. | 158 | 465 | 232.3 | 1.2e-66 |
| Hydrolase 1. | 469 | 818 | 63.7 | 7.1e-16 |
| Cation_ATPase_C 1. | 879 | 1061 | 204.3 | 3.3e-58 |
3. Sequence Information
Fasta Sequence: XSB2971.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] EIDHAERELR1101-RGQILWFRGL
Arg1101 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu1092 | Ile1093 | Asp1094 | His1095 | Ala1096 | Glu1097 | Arg1098 | Glu1099 | Leu1100 | Arg1101 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg1102 | Gly1103 | Gln1104 | Ile1105 | Leu1106 | Trp1107 | Phe1108 | Arg1109 | Gly1110 | Leu1111 |
Sequence conservation (by blast)
* References
[PubMed ID: 2844759] Verma AK, Filoteo AG, Stanford DR, Wieben ED, Penniston JT, Strehler EE, Fischer R, Heim R, Vogel G, Mathews S, et al., Complete primary structure of a human plasma membrane Ca2+ pump. J Biol Chem. 1988 Oct 5;263(28):14152-9.