XSB2983 : troponin T2, cardiac isoform a [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0066
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Putative uncharacterized protein; Tnnt2 protein; troponin T2; cardiac isoform a; cardiac TnT |
| Gene Names | Tnnt2; troponin T2, cardiac |
| Gene Locus | 1 60.0 cM; chromosome 1 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001123646 | NM_001130174 | 21956 | Q6P3Z7_MOUSE | N/A | N/A | N/A | mmu:21956 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 302 aa
Average Mass: 35.927 kDa
Monoisotopic Mass: 35.905 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 85 --- | ||||
| Troponin 1. | 110 | 251 | 174.4 | 3.3e-49 |
3. Sequence Information
Fasta Sequence: XSB2983.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VEDTKPKPSR85-LFMPNLVPPK
Arg85 
Leu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val76 | Glu77 | Asp78 | Thr79 | Lys80 | Pro81 | Lys82 | Pro83 | Ser84 | Arg85 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu86 | Phe87 | Met88 | Pro89 | Asn90 | Leu91 | Val92 | Pro93 | Pro94 | Lys95 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EANVEEVGPDEEAKDAEEGPVEDTKPKPSRLFMPNLVPPKIPDGERVDFDDIHRKRVEKD |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Mus musculus | 127.00 | 35 | Tnnt2 protein |
| 2 | Rattus norvegicus | 116.00 | 48 | troponin T2, cardiac |
| 3 | N/A | 116.00 | 18 | B |
| 4 | Cavia porcellus | 100.00 | 6 | cardiac troponin 2 embryonic #1 isoform |
| 5 | Felis catus | 99.00 | 2 | cardiac troponin T |
| 6 | Macaca mulatta | 98.60 | 6 | PREDICTED: similar to Troponin T, cardiac muscle ( |
| 7 | Canis familiaris | 96.30 | 6 | troponin T isoform 1 |
| 8 | Canis lupus familiaris | 96.30 | 1 | troponin T type 2, cardiac |
| 9 | Homo sapiens | 95.50 | 34 | troponin T type 2 (cardiac), isoform CRA_c |
| 10 | Pan troglodytes | 95.50 | 12 | PREDICTED: similar to troponin T type 2, cardiac i |
| 11 | Oryctolagus cuniculus | 94.70 | 1 | AAB51160.1 |
| 12 | Monodelphis domestica | 94.00 | 2 | PREDICTED: similar to cardiac troponin T |
| 13 | Bos taurus | 90.90 | 5 | troponin T type 2, cardiac |
| 14 | Xenopus laevis | 77.80 | 11 | Unknown (protein for MGC:132283) |
| 15 | Danio rerio | 77.40 | 17 | troponin T1, skeletal, slow |
| 16 | Sus scrofa | 75.90 | 8 | troponin T slow type isoform sTnT2 |
| 17 | synthetic construct | 75.90 | 3 | troponin T1, skeletal, slow |
| 18 | Meleagris gallopavo | 73.90 | 2 | cardiac troponin T isoform |
| 19 | Gallus gallus | 72.00 | 3 | troponin T type 2, cardiac |
| 20 | Sparus aurata | 71.60 | 4 | skeletal troponin T |
| 21 | Bufo marinus | 71.20 | 2 | high molecular weight slow troponin T |
| 22 | Tetraodon nigroviridis | 68.60 | 4 | unnamed protein product |
| 23 | Salmo trutta | 61.20 | 1 | slow myotomal muscle troponin-T isoform 1S |
| 24 | Hyla chrysoscelis | 56.20 | 1 | troponin T |
| 25 | Coturnix japonica | 54.70 | 12 | fast troponin T isoform |
| 26 | Xenopus tropicalis | 54.70 | 2 | troponin T3, skeletal, fast |
| 27 | human, familial hypertrophic cardiomyopathy, family AW, Peptide Partial Mutant, 25 aa | 53.50 | 1 | troponin T {Ile79Asn} |
| 28 | rabbits, skeletal muscle, Peptide, 249 aa | 52.80 | 1 | troponin T beta isoform, TnT beta isoform, TnT-5 { |
| 29 | Halocynthia roretzi | 49.30 | 1 | troponin T |
Top-ranked sequences
| organism | matching |
|---|---|
| Mus musculus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 |
| Rattus norvegicus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | |||||||||+|||+|||||+||||||#||||||||||||||||||||||||||+||| Sbjct 51 EDKAEEVGPDEEARDAEDGPVEDSKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRMEKD 110 |
| N/A | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | |||||||||+|||+|||||+||||||#||||||||||||||||||||||||||+||| Sbjct 49 EDKAEEVGPDEEARDAEDGPVEDSKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRMEKD 108 |
| Cavia porcellus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 || || | +|| ++||+||||++|||| |#||||||||||||||||||||||||||+||| Sbjct 50 EAKAEEDGEEEEGREAEDGPVEESKPKP-R#LFMPNLVPPKIPDGERVDFDDIHRKRMEKD 108 |
| Felis catus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | ||| | +||||+ |+||||++|||| |# |||||||||||||||||||||||||+||| Sbjct 49 ETNVEGDGQEEEAKETEDGPVEESKPKP-R#PFMPNLVPPKIPDGERVDFDDIHRKRMEKD 107 |
| Macaca mulatta | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || | +||||+||+||+|++|||| |# |||||||||||||||||||||||||+||| Sbjct 143 ETRAEEDGEEEEAKEAEDGPMEESKPKP-R#SFMPNLVPPKIPDGERVDFDDIHRKRMEKD 201 |
| Canis familiaris | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | | | | + |||+||+||||++|||| |# |||||||||||||||||||||||||+||| Sbjct 49 ETNAEGDGQEGEAKEAEDGPVEESKPKP-R#PFMPNLVPPKIPDGERVDFDDIHRKRMEKD 107 |
| Canis lupus familiaris | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | | | | + |||+||+||||++|||| |# |||||||||||||||||||||||||+||| Sbjct 35 ETNAEGDGQEGEAKEAEDGPVEESKPKP-R#PFMPNLVPPKIPDGERVDFDDIHRKRMEKD 93 |
| Homo sapiens | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || +||||+||+||+|++|||| |# |||||||||||||||||||||||||+||| Sbjct 50 ETRAEEDEEEEEAKEAEDGPMEESKPKP-R#SFMPNLVPPKIPDGERVDFDDIHRKRMEKD 108 |
| Pan troglodytes | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || +||||+||+||+|++|||| |# |||||||||||||||||||||||||+||| Sbjct 50 ETRAEEDEEEEEAKEAEDGPMEESKPKP-R#SFMPNLVPPKIPDGERVDFDDIHRKRMEKD 108 |
| Oryctolagus cuniculus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || | +|| |+ |+||||++|||| |# |||||||||||||||||||||||||+||| Sbjct 60 ETQAEEDGQEEEDKEDEDGPVEESKPKP-R#PFMPNLVPPKIPDGERVDFDDIHRKRMEKD 118 |
| Monodelphis domestica | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 |+ ||| +|| |+ |+||||++|||| +# |||||+|||||||||||||||||||+||| Sbjct 71 ESKVEEQEEEEEVKEVEDGPVEESKPKP-K#PFMPNLIPPKIPDGERVDFDDIHRKRMEKD 129 |
| Bos taurus | Query 63 GPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | +|| ++||+||||+ |||| |# |||||||||||||||||||||||||+||| Sbjct 44 GEEEEGREAEDGPVEEFKPKP-R#PFMPNLVPPKIPDGERVDFDDIHRKRMEKD 95 |
| Xenopus laevis | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || | +|| + || |++|||| +#||||||+| ||||||+||||||||||+||| Sbjct 24 EEEPEEDGNEEEVNEEEE---EESKPKP-K#LFMPNLIPLKIPDGEKVDFDDIHRKRMEKD 79 |
| Danio rerio | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | + | ||| | | ||||||| +#+|+||++|||+||||+|||||+|||||||| Sbjct 49 EGDEPEETHQEEADDEHEAE-EDTKPKP-K#MFVPNIIPPKLPDGEKVDFDDLHRKRVEKD 106 |
| Sus scrofa | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || |+|| +| | |+ +|||||# +| |+|||||+|||||||||||||+||| Sbjct 6 EQEYEEEQPEEE--EAAEEEEEEERPKPSR#PVVPPLIPPKIPEGERVDFDDIHRKRMEKD 63 |
| synthetic construct | Query 56 EANVEEVGPDEEAKDAEEG------PV---EDTKPKPSR#LFMPNLVPPKIPDGERVDFDD 106 | || |+||| + || || |+ +|||||# +| |+|||||+|||||||| Sbjct 6 EQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSR#PVVPPLIPPKIPEGERVDFDD 65 Query 107 IHRKRVEKD 115 |||||+||| Sbjct 66 IHRKRMEKD 74 |
| Meleagris gallopavo | Query 60 EEVGPDEEAK--DAEEGPVE-DTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | |+|| | |+ | | ++|||| +# |||||||||||||||+|||||||||+||| Sbjct 46 ETKAPEEEGGEGDREQEPGEGESKPKP-K#PFMPNLVPPKIPDGERLDFDDIHRKRMEKD 103 |
| Gallus gallus | Query 56 EANVEEVGPDEEAK-DAEEGPVE-DTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVE 113 | | | | + | |+ | | ++|||| +# |||||||||||||||+|||||||||+| Sbjct 52 EQEDETKAPGEGGEGDREQEPGEGESKPKP-K#PFMPNLVPPKIPDGERLDFDDIHRKRME 110 Query 114 KD 115 || Query 114 KD 115 |
| Sparus aurata | Query 60 EEVGPDEEAKDAE----EGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 ||| +|| +| | | |++||+ # ++||+ |||+||||+|||||+|||||||| Sbjct 25 EEVEEEEEEQDNETEKKEEQEEESKPRHKT#TYVPNIAPPKLPDGEKVDFDDLHRKRVEKD 84 |
| Bufo marinus | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || +|| + || |+ +|+| |# || | |||||+|||||||||||||+||| Sbjct 10 EEQQEEEEQEEEKEPTEEAGGEEERPRP-R#PMMPRLAPPKIPEGERVDFDDIHRKRMEKD 68 |
| Tetraodon nigroviridis | Query 70 DAEE--GPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 |+|| | |+++|+| # ++||+ |||+||||+|||||+||||+||| Sbjct 3 DSEEIKGEHEESRPRPKA#TYVPNMAPPKLPDGEKVDFDDLHRKRLEKD 50 |
| Salmo trutta | Query 56 EANVEEVGPDEEAKDAE-EGPVEDTKPKPSR#LFMPNLVPPKIPDGE-RVDFDDIHRKRVE 113 | ++|| || | | +|+| || +# ||||+ |||+|+|+ +|||||+|||| | Sbjct 32 EPDIEEPTAVEETPAEEASGETQDSKAKP-K#SFMPNVAPPKLPEGDGKVDFDDLHRKRQE 90 Query 114 KD 115 || Query 114 KD 115 |
| Hyla chrysoscelis | Query 59 VEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 ||| +|||++ || + |||| # + |||||||+|||||| +|| || Sbjct 10 VEEEYEEEEAEEVEEHHEAEEKPKPK-#-----ITAPKIPDGEKVDFDDIQKKRQNKD 60 |
| Coturnix japonica | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 | || +|| ++ || | |+ ||+ # | ||||+||+|||||| +|| || Sbjct 5 EHGEEEYEEEEEVQEEEEAPEEEEKPRIK-#-----LTAPKIPEGEKVDFDDIQKKRQNKD 58 |
| Xenopus tropicalis | Query 56 EANVEEVGPDEEAKDAEEGPVEDTKPKPSR#LF----------MPNLVPPKIPDGERVDFD 105 | || +||+++ || || + |+ # + | | ||||+||+|||| Sbjct 11 EEEYEEEAQEEESQEQEEEPVVEEAPQEEE#AYGEAEEEEEKPKPKLTAPKIPEGEKVDFD 70 Query 106 DIHRKRVEKD 115 || +|| || Sbjct 71 DIQKKRQNKD 80 |
| human, familial hypertrophic cardiomyopathy, family AW, Peptide Partial Mutant, 25 aa | Query 88 MPNLVPPKIPDGERVDFDDIHRKRV 112 |||||||| |||||||||||||||+ Sbjct 1 MPNLVPPKNPDGERVDFDDIHRKRM 25 |
| rabbits, skeletal muscle, Peptide, 249 aa | Query 58 NVEEVGPDEEAKDAEEGPVEDTKPKPSR#LFMPNLVPPKIPDGERVDFDDIHRKRVEKD 115 +||| +|| || |+ ||+| # | ||||+||+|||||| +|| || Sbjct 7 HVEEQYEEEEEAQEEEEVHEEEKPRPK-#-----LTAPKIPEGEKVDFDDIQKKRQNKD 58 |
| Halocynthia roretzi | Query 88 MPNLVPPKIPDGERVDFDDIHRKRVEK 114 |||+ |||||||| +| +||||||++| Sbjct 12 MPNITPPKIPDGEVIDLEDIHRKRMDK 38 |
* References
[PubMed ID: 19166829] Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y, Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol. 2009 Mar 15;327(2):376-85. Epub 2009 Jan 3.
[PubMed ID: 19132680] ... Yu H, Meng Y, Wang LS, Jin X, Gao LF, Zhou L, Ji K, Li Y, Zhao LJ, Chen GQ, Zhao XJ, Yang B, Differential protein expression in heart in UT-B null mice with cardiac conduction defects. Proteomics. 2009 Feb;9(3):504-11.
[PubMed ID: 19075228] ... Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA, A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20333-8. Epub 2008 Dec 15.
[PubMed ID: 18987029] ... Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL, Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008 Dec;135(23):3923-33. Epub 2008 Nov 5.
[PubMed ID: 18973680] ... Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008 Oct 30;9:511.
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[PubMed ID: 9637714] ... Tardiff JC, Factor SM, Tompkins BD, Hewett TE, Palmer BM, Moore RL, Schwartz S, Robbins J, Leinwand LA, A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Jun 15;101(12):2800-11.
[PubMed ID: 8654947] ... Jin JP, Wang J, Zhang J, Expression of cDNAs encoding mouse cardiac troponin T isoforms: characterization of a large sample of independent clones. Gene. 1996 Feb 12;168(2):217-21.
[PubMed ID: 7575526] ... Jin JP, Zhang J, Wang J, An embryonic alternative transcription initiation site and the 5'-upstream structure of mouse cardiac troponin T gene. Biochem Biophys Res Commun. 1995 Sep 25;214(3):1168-74.
[PubMed ID: 7958896] ... Chen Z, Friedrich GA, Soriano P, Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994 Oct 1;8(19):2293-301.