XSB2988 : major intrinsic protein of lens fiber [Oryctolagus cuniculus]
[ CaMP Format ]
This entry is computationally expanded from SB0003
* Basic Information
| Organism | Oryctolagus cuniculus (rabbit) |
| Protein Names | Lens fiber major intrinsic protein; Aquaporin-0; major intrinsic protein of lens fiber; aquaporin |
| Gene Names | MIP; major intrinsic protein of lens fiber |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001093431 | NM_001099961 | 100101574 | MIP_RABIT | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 263 aa
Average Mass: 28.171 kDa
Monoisotopic Mass: 28.153 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| MIP 1. | 3 | 219 | 423.2 | 4.2e-124 |
3. Sequence Information
Fasta Sequence: XSB2988.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] SVSERLSILK238-GARPSDSNGQ
Lys238 
Gly
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser229 | Val230 | Ser231 | Glu232 | Arg233 | Leu234 | Ser235 | Ile236 | Leu237 | Lys238 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly239 | Ala240 | Arg241 | Pro242 | Ser243 | Asp244 | Ser245 | Asn246 | Gly247 | Gln248 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| IIGGGLASLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Oryctolagus cuniculus | 109.00 | 1 | aquaporin |
| 2 | Mus musculus | 108.00 | 15 | major intrinsic protein of eye lens fiber |
| 3 | Rattus norvegicus | 108.00 | 11 | PREDICTED: similar to major intrinsic protein of e |
| 4 | N/A | 108.00 | 6 | - |
| 5 | Rattus rattus | 108.00 | 2 | MIP_RAT Lens fiber major intrinsic protein (Aquapo |
| 6 | Canis lupus familiaris | 108.00 | 2 | major intrinsic protein of lens fiber |
| 7 | Homo sapiens | 106.00 | 17 | putative alternative lens membrane intrinsic prote |
| 8 | Cavia porcellus | 105.00 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqua |
| 9 | Bos taurus | 99.40 | 5 | major intrinsic protein of lens fiber |
| 10 | Macaca mulatta | 95.50 | 4 | PREDICTED: major intrinsic protein of lens fiber |
| 11 | Monodelphis domestica | 92.80 | 2 | PREDICTED: similar to lens-specific aquaporin-0; M |
| 12 | Rana pipiens | 84.00 | 1 | CAA40291.1 |
| 13 | Tetraodon nigroviridis | 77.00 | 4 | unnamed protein product |
| 14 | Xenopus laevis | 73.90 | 5 | hypothetical protein LOC495140 |
| 15 | Xenopus tropicalis | 73.90 | 3 | hypothetical protein LOC100037914 |
| 16 | Danio rerio | 71.60 | 6 | major intrinsic protein of lens fiber 1 |
| 17 | Fundulus heteroclitus | 69.30 | 1 | AF191906_1 lens major intrinsic protein |
| 18 | Gallus gallus | 52.80 | 5 | major intrinsic protein of lens fiber |
| 19 | Ovis aries | 44.30 | 3 | AQP2_SHEEP Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQP |
| 20 | Pan troglodytes | 43.90 | 8 | PREDICTED: aquaporin 2 isoform 3 |
| 21 | Bufo marinus | 43.90 | 3 | water channel homolog |
| 22 | synthetic construct | 43.90 | 3 | aquaporin 2 |
| 23 | human, kidney, Peptide, 271 aa | 43.90 | 1 | hAQP-CD=collecting duct aquaporin |
| 24 | Notomys alexis | 43.10 | 2 | aquaporin 2 |
| 25 | Canis familiaris | 42.70 | 5 | PREDICTED: similar to aquaporin 2 |
| 26 | Coturnix coturnix | 42.70 | 2 | aquaporin-2 |
| 27 | Equus caballus | 38.90 | 1 | aquaporin 5 |
| 28 | Passer domesticus | 37.00 | 1 | aquaporin-1 |
| 29 | Hyla chrysoscelis | 35.80 | 2 | aquaporin 2-like |
| 30 | Hyla japonica | 35.40 | 2 | water channel protein AQP-h2 |
| 31 | Sus scrofa | 35.00 | 1 | aquaporin 1 |
| 32 | Pongo pygmaeus | 34.70 | 1 | AQP1_PONPY Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (W |
| 33 | Anguilla anguilla | 34.70 | 1 | aquaporin 1 |
| 34 | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | 33.50 | 1 | dienelactone hydrolase domain protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Oryctolagus cuniculus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Mus musculus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#||||||||||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus norvegicus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#||||||||||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| N/A | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#||||||||||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus rattus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#||||||||||||||||||||||||| Sbjct 207 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 261 |
| Canis lupus familiaris | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#||||||||||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Homo sapiens | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#|||||||||||||||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELNTQAL 263 |
| Cavia porcellus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |
| Bos taurus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 +|| || |||||||||||||||||||||||#|+|||+|||||| |||||||||||| Sbjct 209 VIGAGLGSLLYDFLLFPRLKSVSERLSILK#GSRPSESNGQPEVTGEPVELKTQAL 263 |
| Macaca mulatta | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||||| ||||||||||||||+|||||+|+#| +| |+||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLR#GVKPEDANGQPEVTGEPVELNTQAL 263 |
| Monodelphis domestica | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||| | ||||||||||+|||||||+|||#| ||+|| |||| |||||||||||| Sbjct 217 IIGGTLGGLLYDFLLFPRIKSVSERLTILK#GIRPNDSEGQPEVTGEPVELKTQAL 271 |
| Rana pipiens | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||| | |+|||+||||++ +||||||||#||||++ || | ||||+|||||+| Sbjct 208 IIGGALGGLVYDFILFPRMRGLSERLSILK#GARPAEPEGQQEATGEPIELKTQSL 262 |
| Tetraodon nigroviridis | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 +||| + +|||||+||||++ +||||+ ||#| || ++ || | |||+||||||| Sbjct 209 MIGGAMGALLYDFMLFPRMRGLSERLATLK#GTRPPEAEGQQETRGEPIELKTQAL 263 |
| Xenopus laevis | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||| + |+|||+||||++ ++|| ||||#||||+ || | |+|+|||||+| Sbjct 210 IIGGAVGGLVYDFILFPRMRGLNERFSILK#GARPAVPEGQRETAGDPIELKTQSL 264 |
| Xenopus tropicalis | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |||| + |+|||+||||++ ++|||||||#||||++ || | +|+|||||+| Sbjct 210 IIGGAVGGLVYDFILFPRMRGLNERLSILK#GARPAEPEGQRETIRDPIELKTQSL 264 |
| Danio rerio | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 +|| + +|||||+||||++ +||||++||#| +|++ | | |||+||||||| Sbjct 209 MIGAAMGALLYDFMLFPRVRGLSERLAVLK#GNKPTEPEAQQETRGEPIELKTQAL 263 |
| Fundulus heteroclitus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 +||| + +||||||||||++ +||||+ ||#| | ++ | | || +||||||| Sbjct 209 MIGGAIGALLYDFLLFPRMRGLSERLATLK#GTRTPEAEAQQETRGESIELKTQAL 263 |
| Gallus gallus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 ++| ||+|||+ | || +|++|||++|+#| |+ + || ||+||||| | Sbjct 209 LLGAALAALLYELALCPRARSMAERLAVLR#GEPPA-AAPPPEPPAEPLELKTQGL 262 |
| Ovis aries | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| +|||||+++||| ||+||||++||#| | Sbjct 209 LVGAIVASLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| Pan troglodytes | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| | ||||+++||| ||+||||++||#| | Sbjct 201 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 234 |
| Bufo marinus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#G 239 ++|| ||||||++||+| ||+|||+++||#| Sbjct 209 LVGGILASLLYNYLLYPYNKSLSERIAVLK#G 239 |
| synthetic construct | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| | ||||+++||| ||+||||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| human, kidney, Peptide, 271 aa | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| | ||||+++||| ||+||||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| Notomys alexis | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| + ||||++|||| ||+ |||++||#| | Sbjct 89 LVGAIIGSLLYNYLLFPSAKSLQERLAVLK#GLEP 122 |
| Canis familiaris | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARP 242 ++| | ||||+++||| ||++|||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLAERLAVLK#GLEP 242 |
| Coturnix coturnix | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPE 250 ++| ||++|+++|||+ |+ ||||+| |#| | + + | Sbjct 210 LVGAAAASIIYNYILFPQSKTFSERLAIFK#GMEPEEDWAERE 251 |
| Equus caballus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#G 239 |+| ||++|| +|||| |+|||++|+|#| Sbjct 28 IVGAALAAILYFYLLFPNSLSLSERVAIVK#G 58 |
| Passer domesticus | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELK 259 |||| |+|+|||+| || +++|+ + # + + + + + ||+| Sbjct 219 IIGGASAALIYDFILAPRTSDLTDRMKVWT#SGQVEEYDLEGDDMNSRVEMK 269 |
| Hyla chrysoscelis | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#G 239 + | + ||+|+|+| | |+ |||++||+#| Sbjct 214 LFGATVGSLMYNFILIPNTKTFSERIAILR#G 244 |
| Hyla japonica | Query 210 IGGGLASLLYDFLLFPRLKSVSERLSILK#GARPS 243 +| ||||+|+++| |+ +| ||+||+| #| |+ Sbjct 210 VGAILASLIYNYVLCPQEQSFSEKLSVLL#GRIPA 243 |
| Sus scrofa | Query 210 IGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELK 259 ||| || |+|||+| || +++|+ + # + + + + ||+| Sbjct 220 IGGALAVLIYDFILAPRSSDLTDRVKVWT#SGQVEEYDLDGDDINSRVEMK 269 |
| Pongo pygmaeus | Query 210 IGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELK 259 ||| || |+|||+| || ++|+ + # + + + + ||+| Sbjct 218 IGGALAVLIYDFILAPRSSDFTDRVKVWT#SGQVEEYDLDADDINSRVEMK 267 |
| Anguilla anguilla | Query 209 IIGGGLASLLYDFLLFPRLKSVSERLSIL 237 | || +|+|+||+|| |+| ++||| +| Sbjct 209 ISGGLVAALVYDYLLHPKLGDLTERLKVL 237 |
| Aeromonas hydrophila subsp. hydrophila ATCC 7966 | Query 209 IIGGG----LASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGE 254 +|||| | | || | +| +|| |++#|| | ||+ ||+ Sbjct 274 VIGGGTPGAFGSYRDGFELFGRARSPQKRLQIVE#GASHYDLYDQPDATGQ 323 |
* References
None.