XSB2990 : Lens fiber major intrinsic protein
[ CaMP Format ]
This entry is computationally expanded from SB0003
* Basic Information
| Organism | Cavia porcellus (domestic guinea pig) |
| Protein Names | Aquaporin-0 |
| Gene Names | AQP0 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 263 aa
Average Mass: 0.000 kDa
Monoisotopic Mass: 0.000 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| MIP 1. | 3 | 219 | 409.9 | 4.1e-120 |
3. Sequence Information
Fasta Sequence: XSB2990.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] SVSERLSILK238-GTRPSDNNGQ
Lys238 
Gly
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser229 | Val230 | Ser231 | Glu232 | Arg233 | Leu234 | Ser235 | Ile236 | Leu237 | Lys238 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly239 | Thr240 | Arg241 | Pro242 | Ser243 | Asp244 | Asn245 | Asn246 | Gly247 | Gln248 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| IIGGGLGSLLYDFLLFPRLKSVSERLSILKGTRPSDNNGQPEGTGEPVELKTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Cavia porcellus | 111.00 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqua |
| 2 | Mus musculus | 107.00 | 15 | major intrinsic protein of eye lens fiber |
| 3 | Rattus norvegicus | 107.00 | 7 | PREDICTED: similar to major intrinsic protein of e |
| 4 | N/A | 107.00 | 5 | - |
| 5 | Rattus rattus | 107.00 | 2 | MIP_RAT Lens fiber major intrinsic protein (Aquapo |
| 6 | Canis lupus familiaris | 107.00 | 1 | major intrinsic protein of lens fiber |
| 7 | Homo sapiens | 105.00 | 16 | putative alternative lens membrane intrinsic prote |
| 8 | Oryctolagus cuniculus | 105.00 | 1 | aquaporin |
| 9 | Bos taurus | 100.00 | 4 | major intrinsic protein of lens fiber |
| 10 | Macaca mulatta | 96.70 | 4 | PREDICTED: major intrinsic protein of lens fiber |
| 11 | Monodelphis domestica | 94.00 | 2 | PREDICTED: similar to lens-specific aquaporin-0; M |
| 12 | Rana pipiens | 84.30 | 1 | CAA40291.1 |
| 13 | Tetraodon nigroviridis | 80.10 | 3 | unnamed protein product |
| 14 | Danio rerio | 74.30 | 6 | major intrinsic protein of lens fiber 1 |
| 15 | Xenopus laevis | 74.30 | 4 | hypothetical protein LOC495140 |
| 16 | Xenopus tropicalis | 74.30 | 2 | hypothetical protein LOC100037914 |
| 17 | Fundulus heteroclitus | 72.40 | 1 | AF191906_1 lens major intrinsic protein |
| 18 | Gallus gallus | 50.10 | 5 | major intrinsic protein of lens fiber |
| 19 | Pan troglodytes | 46.20 | 7 | PREDICTED: aquaporin 2 isoform 3 |
| 20 | synthetic construct | 46.20 | 3 | aquaporin 2 |
| 21 | human, kidney, Peptide, 271 aa | 46.20 | 1 | hAQP-CD=collecting duct aquaporin |
| 22 | Notomys alexis | 45.40 | 1 | aquaporin 2 |
| 23 | Canis familiaris | 45.10 | 4 | PREDICTED: similar to aquaporin 2 |
| 24 | Bufo marinus | 44.30 | 2 | water channel homolog |
| 25 | Ovis aries | 42.70 | 2 | AQP2_SHEEP Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQP |
| 26 | Coturnix coturnix | 41.60 | 2 | aquaporin-2 |
| 27 | Equus caballus | 39.30 | 1 | aquaporin 5 |
| 28 | Hyla chrysoscelis | 38.10 | 1 | aquaporin 2-like |
| 29 | Passer domesticus | 34.70 | 1 | aquaporin-1 |
| 30 | Aeromonas hydrophila subsp. hydrophila ATCC 7966 | 33.90 | 1 | dienelactone hydrolase domain protein |
| 31 | Hyla japonica | 33.90 | 1 | water channel protein AQP-h2 |
| 32 | Anguilla anguilla | 33.10 | 1 | aquaporin 1 |
| 33 | Sus scrofa | 32.70 | 1 | aquaporin 1 |
| 34 | Sinorhizobium medicae WSM419 | 32.30 | 1 | conserved hypothetical transmembrane protein |
| 35 | Pongo pygmaeus | 32.30 | 1 | AQP1_PONPY Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (W |
Top-ranked sequences
| organism | matching |
|---|---|
| Cavia porcellus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |
| Mus musculus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus norvegicus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| N/A | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus rattus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 207 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 261 |
| Canis lupus familiaris | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Homo sapiens | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ||||||||||||||||||||||||||||||#| ||||+||||||||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELNTQAL 263 |
| Oryctolagus cuniculus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||||| |||||||||||||||||||||||#| ||||+|||||||||||||||||| Sbjct 209 IIGGGLASLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Bos taurus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 +|| ||||||||||||||||||||||||||#|+|||++||||| |||||||||||| Sbjct 209 VIGAGLGSLLYDFLLFPRLKSVSERLSILK#GSRPSESNGQPEVTGEPVELKTQAL 263 |
| Macaca mulatta | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||||||||||||||||||||+|||||+|+#| +| | ||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLR#GVKPEDANGQPEVTGEPVELNTQAL 263 |
| Monodelphis domestica | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||| || ||||||||||+|||||||+|||#| ||+|+ |||| |||||||||||| Sbjct 217 IIGGTLGGLLYDFLLFPRIKSVSERLTILK#GIRPNDSEGQPEVTGEPVELKTQAL 271 |
| Rana pipiens | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||| || |+|||+||||++ +||||||||#| ||++ || | ||||+|||||+| Sbjct 208 IIGGALGGLVYDFILFPRMRGLSERLSILK#GARPAEPEGQQEATGEPIELKTQSL 262 |
| Tetraodon nigroviridis | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 +||| +|+|||||+||||++ +||||+ ||#|||| + || | |||+||||||| Sbjct 209 MIGGAMGALLYDFMLFPRMRGLSERLATLK#GTRPPEAEGQQETRGEPIELKTQAL 263 |
| Danio rerio | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 +|| +|+|||||+||||++ +||||++||#| +|++ | | |||+||||||| Sbjct 209 MIGAAMGALLYDFMLFPRVRGLSERLAVLK#GNKPTEPEAQQETRGEPIELKTQAL 263 |
| Xenopus laevis | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||| +| |+|||+||||++ ++|| ||||#| ||+ || | |+|+|||||+| Sbjct 210 IIGGAVGGLVYDFILFPRMRGLNERFSILK#GARPAVPEGQRETAGDPIELKTQSL 264 |
| Xenopus tropicalis | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |||| +| |+|||+||||++ ++|||||||#| ||++ || | +|+|||||+| Sbjct 210 IIGGAVGGLVYDFILFPRMRGLNERLSILK#GARPAEPEGQRETIRDPIELKTQSL 264 |
| Fundulus heteroclitus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 +||| +|+||||||||||++ +||||+ ||#||| + | | || +||||||| Sbjct 209 MIGGAIGALLYDFLLFPRMRGLSERLATLK#GTRTPEAEAQQETRGESIELKTQAL 263 |
| Gallus gallus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 ++| | +|||+ | || +|++|||++|+#| |+ || ||+||||| | Sbjct 209 LLGAALAALLYELALCPRARSMAERLAVLR#GEPPA-AAPPPEPPAEPLELKTQGL 262 |
| Pan troglodytes | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| ||||||+++||| ||+||||++||#| | Sbjct 201 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 234 |
| synthetic construct | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| ||||||+++||| ||+||||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| human, kidney, Peptide, 271 aa | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| ||||||+++||| ||+||||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| Notomys alexis | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| +|||||++|||| ||+ |||++||#| | Sbjct 89 LVGAIIGSLLYNYLLFPSAKSLQERLAVLK#GLEP 122 |
| Canis familiaris | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| ||||||+++||| ||++|||++||#| | Sbjct 209 LVGAILGSLLYNYVLFPPAKSLAERLAVLK#GLEP 242 |
| Bufo marinus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GT 240 ++|| | ||||++||+| ||+|||+++||#|| Sbjct 209 LVGGILASLLYNYLLYPYNKSLSERIAVLK#GT 240 |
| Ovis aries | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRP 242 ++| + ||||+++||| ||+||||++||#| | Sbjct 209 LVGAIVASLLYNYVLFPPAKSLSERLAVLK#GLEP 242 |
| Coturnix coturnix | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPE 250 ++| |++|+++|||+ |+ ||||+| |#| | ++ + | Sbjct 210 LVGAAAASIIYNYILFPQSKTFSERLAIFK#GMEPEEDWAERE 251 |
| Equus caballus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GT 240 |+| | ++|| +|||| |+|||++|+|#|| Sbjct 28 IVGAALAAILYFYLLFPNSLSLSERVAIVK#GT 59 |
| Hyla chrysoscelis | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#G 239 + | +|||+|+|+| | |+ |||++||+#| Sbjct 214 LFGATVGSLMYNFILIPNTKTFSERIAILR#G 244 |
| Passer domesticus | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELK 259 |||| +|+|||+| || +++|+ + # + + + + + ||+| Sbjct 219 IIGGASAALIYDFILAPRTSDLTDRMKVWT#SGQVEEYDLEGDDMNSRVEMK 269 |
| Aeromonas hydrophila subsp. hydrophila ATCC 7966 | Query 209 IIGGG----LGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGE 254 +|||| || | || | +| +|| |++#| | ||+ ||+ Sbjct 274 VIGGGTPGAFGSYRDGFELFGRARSPQKRLQIVE#GASHYDLYDQPDATGQ 323 |
| Hyla japonica | Query 210 IGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPS 243 +| | ||+|+++| |+ +| ||+||+| #| |+ Sbjct 210 VGAILASLIYNYVLCPQEQSFSEKLSVLL#GRIPA 243 |
| Anguilla anguilla | Query 209 IIGGGLGSLLYDFLLFPRLKSVSERLSIL 237 | || + +|+||+|| |+| ++||| +| Sbjct 209 ISGGLVAALVYDYLLHPKLGDLTERLKVL 237 |
| Sus scrofa | Query 210 IGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELK 259 ||| | |+|||+| || +++|+ + # + + + + ||+| Sbjct 220 IGGALAVLIYDFILAPRSSDLTDRVKVWT#SGQVEEYDLDGDDINSRVEMK 269 |
| Sinorhizobium medicae WSM419 | Query 211 GGGL--GSLLYDFLLFPRLKSVS-ERLSILK#GTRP--------SDNNGQPEGTGEPVELK 259 |||+ |+|++ +|+ ||++ + | +|+#| | || +| |+|| | |+| Sbjct 45 GGGMSFGTLIFLVILYFVLKAMGIDMLQVLE#GGGPANMPGFEQSDGSGAPQGTAEEEEMK 104 |
| Pongo pygmaeus | Query 210 IGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELK 259 ||| | |+|||+| || ++|+ + # + + + + ||+| Sbjct 218 IGGALAVLIYDFILAPRSSDFTDRVKVWT#SGQVEEYDLDADDINSRVEMK 267 |
* References
[PubMed ID: 15064681] Han J, Little M, David LL, Giblin FJ, Schey KL, Sequence and peptide map of guinea pig aquaporin 0. Mol Vis. 2004 Mar 26;10:215-22.