CL0003 : Chain A, Crystal Structure Of M-Calpain
[ CaMP Format ]
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain |
| Gene Names | Capn2 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 700 aa
Average Mass: 79.903 kDa
Monoisotopic Mass: 79.853 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 45 | 344 | 802.7 | 2.3e-238 |
| Calpain_III 1. | 355 | 510 | 385.6 | 8.7e-113 |
| efhand 1. | 576 | 604 | 20.4 | 0.0074 |
| efhand 2. | 606 | 634 | 19.4 | 0.015 |
| efhand 3. | 671 | 698 | 3.2 | 9.5 |
3. Sequence Information
Fasta Sequence: CL0003.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* References
[PubMed ID: 9228945] Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M, Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat Struct Biol. 1997 Jul;4(7):532-8.