logo CaMPDB: Calpain for Modulatory Proteolysis Database

Sixteen calpain types of vertebrates and their reference sequences

typesNCBI Protein ID (CaMP ID)organism
Calpain 1NP_005177 (CL0892)[Homo sapiens]
Calpain 2NP_001739 (CL0890)[Homo sapiens]
Calpain 3NP_000061 (CL0842)[Homo sapiens]
Calpain 5NP_004046 (CL0891)[Homo sapiens]
Calpain 6NP_055104 (CL0904)[Homo sapiens]
Calpain 7NP_055111 (CL0905)[Homo sapiens]
Calpain 8XP_943978 (CL1417)[Homo sapiens]
Calpain 9NP_006606 (CL0894)[Homo sapiens]
Calpain 10NP_075571 (CL0913)[Homo sapiens]
Calpain 11NP_008989 (CL0895)[Homo sapiens]
Calpain 12NP_653292 (CL0946)[Homo sapiens]
Calpain 13NP_653176 (CL0945)[Homo sapiens]
Calpain 14EAX00484 (CL0810)[Homo sapiens]
Calpain 15NP_005623 (CL0893)[Homo sapiens]
Calpain 16EAW47827 (CL0767)[Homo sapiens]
Calpain CNP_990634 (CL0963)[Gallus gallus]

Number of sequences in 16 calpain types

organism total 1 2 3 5 6 7 8 9 10 11 12 13 14 15 16 C x
Homo sapiens (human)(177)1615211197717311051037800
Mus musculus (house mouse)(120)1412181186981248406000
Rattus norvegicus (Norway rat)(91)1691855365843403101
Danio rerio (zebrafish)(66)1320450104100001296
Paramecium tetraurelia(66)4002000002000220432
Tetrahymena thermophila SB210(60)0200000402002180032
Unknown.(41)386312141020000001
Canis lupus familiaris (dog)(40)212021311211112100
Caenorhabditis elegans(40)00040288000007028
Trypanosoma cruzi strain CL Brener(32)001002000000080021
Trypanosoma cruzi(32)001002000000080021
Drosophila melanogaster (fruit fly)(31)0000000200000010000
Xenopus laevis (African clawed frog)(30)53040062100200070
Pan troglodytes (chimpanzee)(30)120104216001210000
Bos taurus (cattle)(28)62611120111211101
Tetraodon nigroviridis(25)23340103100003023
Trypanosoma brucei(24)000001000000020021
Leishmania infantum(22)000001000000070014
Leishmania infantum JPCM5(22)000001000000070014
Sus scrofa (pig)(20)80600300300000000
Leishmania major(20)000001100000080010
Leishmania braziliensis(19)000001000000040014
Trichomonas vaginalis G3(19)000000000200000017
Anopheles gambiae str. PEST(18)02000208020002002
Gallus gallus (chicken)(16)34400000000000050
Trypanosoma brucei TREU927(16)000001000000020013
Strongylocentrotus purpuratus(16)00060202000002400
Xenopus tropicalis (Silurana tropicalis)(16)22020230030000020
synthetic construct(15)42012000211002000
Macaca mulatta (rhesus monkey)(14)61100110100012000
Monodelphis domestica (gray short-tailed opossum)(13)01111112101111000
Macaca fascicularis (crab-eating macaque)(12)32200000311000000
Ornithorhynchus anatinus (platypus)(11)01110111101210000
Schistosoma japonicum(11)10000101000000062
Aedes aegypti (Stegomyia aegypti)(10)00100204010001010
Magnaporthe grisea 70-15(10)00000202000000006
Gallus gallus (red jungle fowl)(10)00020111110011100
Caenorhabditis briggsae(10)00010121000001004
Cryptococcus neoformans var. neoformans B-3501A(8)00000200000000006
Coprinopsis cinerea okayama7#130 (Coprinus cinereus okayama7#130)(8)00000101010000005
Leishmania major strain Friedlin(7)00000000000001006
Ovis aries (sheep)(7)00400000000000003
Arabidopsis thaliana (thale cress)(7)00600000000001000
Neurospora crassa(7)00000202000000021
Tribolium castaneum (red flour beetle)(6)00000113000001000
Synechococcus sp. RS9916(6)00000000000000006
Herpetosiphon aurantiacus ATCC 23779(6)00000000000000006
Ostreococcus lucimarinus CCE9901(6)00000000000002004
Aspergillus oryzae(5)00000401000000000
Gibberella zeae PH-1 (anamorph: Fusarium graminearum)(4)10010100000000001
Oryza sativa (japonica cultivar-group)(4)00400000000000000
Aspergillus clavatus NRRL 1(4)00000200000000020
Neosartorya fischeri NRRL 181(4)00000202000000000
Gecarcinus lateralis (blackback land crab)(4)10010011000000000
Oryctolagus cuniculus (rabbit)(4)02200000000000000
Chaetomium globosum CBS 148.51(4)00000200000000002
Candida albicans SC5314(4)00000000000000004
Drosophila pseudoobscura(4)00000004000000000
Aspergillus nidulans FGSC A4(4)00000202000000000
Aspergillus terreus NIH2624(4)02000200000000000
Oncorhynchus mykiss (rainbow trout)(4)12000001000000000
Aspergillus fumigatus Af293(4)00000200000002000
Neurospora crassa OR74A(4)00000101000000011
Schistosoma mansoni(3)00000000000000030
Saccharomyces cerevisiae (baker's yeast)(3)00000000000000003
Nostoc sp. PCC 7120(3)00000000000000003
Apis mellifera (honey bee)(3)00000101000001000
Zea mays(3)00300000000000000
Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)(3)00000000000000003
Frankia alni ACN14a(2)00000000000000002
Plasmodium chabaudi chabaudi(2)00000000000000002
Ustilago maydis 521(2)00000200000000000
Frankia sp. EAN1pec(2)00000000000000002
Phaeosphaeria nodorum SN15(2)01000100000000000
Photorhabdus luminescens subsp. laumondii TTO1(2)00000000000000002
Salinispora tropica CNB-440(2)00000000000000002
Bradyrhizobium sp. ORS278(2)00000000000000002
Plasmodium berghei(2)00000100000000001
Granulibacter bethesdensis CGDNIH1(2)00000000000000002
Bos grunniens (domestic yak)(2)11000000000000000
Aspergillus niger CBS 513.88(2)00000101000000000
Cryptococcus neoformans var. neoformans JEC21 (Filobasidiella neoformans var. neoformans strain JEC21)(2)00000200000000000
Plasmodium falciparum 3D7(2)00000200000000000
Plasmodium berghei strain ANKA(2)00000100000000001
Equus caballus (horse)(2)00100000010000000
Bacteroides thetaiotaomicron VPI-5482(2)00000000000000002
Yarrowia lipolytica CLIB122(2)00000200000000000
Emericella nidulans (anamorph: Aspergillus nidulans)(2)00000200000000000
Coccidioides immitis RS(2)00000200000000000
Geobacter lovleyi SZ(2)00000000000000002
Anabaena variabilis ATCC 29413 (Anabaena flos-aquae UTEX 1444)(2)00000000000000002
Yarrowia lipolytica(2)00000200000000000
Ashbya gossypii ATCC 10895 (Eremothecium gossypii ATCC 10895)(2)00000000000000002
Bos taurus x Bos indicus(2)00000000000000002
Ostreococcus tauri(2)00000000000002000
Candida glabrata CBS 138(2)00000000000000002
Lodderomyces elongisporus NRRL YB-4239(2)00000000000000002
Pongo pygmaeus (orangutan)(2)20000000000000000
Pichia guilliermondii ATCC 6260(2)00000000000000002
Ciona intestinalis(2)00000000000002000
Frankia sp. CcI3(2)00000000000000002
Cryptosporidium parvum Iowa II(2)00000200000000000
Porphyromonas gingivalis W83(2)00000000000000002
Plasmodium chabaudi(2)00000000000000002
Kluyveromyces lactis NRRL Y-1140(2)00000000000000002
Stizostedion vitreum vitreum(2)02000000000000000
Gloeobacter violaceus PCC 7421(2)00000000000000002
Debaryomyces hansenii CBS767(2)00000000000000002
Rhodopseudomonas palustris BisA53(2)00000000000000002
Bradyrhizobium sp. BTAi1(2)00000000000000002
Aspergillus niger(2)00000101000000000
Porphyromonas gingivalis(2)00000000000000002
Vitis vinifera(1)00000001000000000
Anopheles gambiae (African malaria mosquito)(1)00000001000000000
Plasmodium yoelii yoelii(1)00000100000000000
Plasmodium yoelii yoelii str. 17XNL(1)00000100000000000
Saccharum hybrid cultivar(1)00100000000000000
Theileria annulata strain Ankara(1)00000100000000000
Debaryomyces hansenii (anamorph: Candida famata)(1)00000000000000001
Plasmodium vivax (malaria parasite P. vivax)(1)00000100000000000
Theileria parva(1)00000000000000001
Homarus americanus (American lobster)(1)00000001000000000
Oryza sativa(1)00100000000000000
Candida albicans(1)00000000000000001
Eremothecium gossypii (Ashbya gossypii)(1)00000000000000001
Kluyveromyces lactis(1)00000000000000001
Theileria annulata(1)00000100000000000
Nicotiana benthamiana(1)00000001000000000
Oryza sativa (indica cultivar-group)(1)00100000000000000
Pichia stipitis CBS 6054(1)00000000000000001
Filobasidiella neoformans (anamorph: Cryptococcus neoformans)(1)00000100000000000
Theileria parva strain Muguga(1)00000000000000001
Entamoeba histolytica HM-1:IMSS(1)00000000000001000
Candida glabrata(1)00000000000000001
Toxoplasma gondii RH(1)00000100000000000
Coturnix coturnix (common quail)(1)00000000000000010
Sterkiella histriomuscorum (Oxytricha trifallax)(1)00000000000001000
Schistosoma haematobium(1)00000000000000010

Classification procedure

  1. Reference sequences of 16 known classes were selected.
  2. Each entry (sequence) was classified into one of 16 classes using the Smith-Waterman (SW) local alignment algorithm (with naive threshoulding, <500 for "unclassified(x)"). More concretely, 16 SW scores were computed for each sequence and the class of the highest score was assigned. The computed scores are available (calpain_alignments.result) and the detailed table of sw scores, bit scores, and e-values for all pairs are also available (calpain_allpairs_swscores.table).