CL0913 : calpain 10 isoform a
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | calcium-activated neutral protease; calpain 10 isoform a [Homo sapiens]; Calpain-10; 3.4.22.-; Calcium-activated neutral proteinase 10; CANP 10 |
| Gene Names | CAPN10; KIAA1845; calpain 10 |
| Gene Locus | 2q37.3; chromosome 2 |
| GO Function | Not available |
* Information From OMIM
Function: The results of Horikawa et al. (2000) suggested a novel pathway involved in the pathophysiology of diabetes, one that may include, in addition to calpain-10, its substrates, inhibitors, and activators. Calpain-10 may represent the third example of a protease contributing to the development of diabetes, the others being prohormone-processing carboxypeptidase E (OMIM:114855) and prohormone convertase-1 (OMIM:162150), both of which are associated with diabetes and obesity.
* Structure Information
1. Primary Information
Length: 672 aa
Average Mass: 74.938 kDa
Monoisotopic Mass: 74.891 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 13 | 316 | 182.5 | 1.2e-51 |
| Calpain_III 1. | 338 | 494 | 31.4 | 1.8e-09 |
| Calpain_III 2. | 513 | 645 | 14.8 | 3.6e-08 |
3. Sequence Information
Fasta Sequence: CL0913.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 18936436] Chang MH, Lindegren ML, Butler MA, Chanock SJ, Dowling NF, Gallagher M, Moonesinghe R, Moore CA, Ned RM, Reichler MR, Sanders CL, Welch R, Yesupriya A, Khoury MJ, Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol. 2009 Jan 1;169(1):54-66. Epub 2008 Oct 20.