CL0893 : small optic lobes
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | small optic lobes [Homo sapiens]; Calpain-15; 3.4.22.-; Small optic lobes homolog |
| Gene Names | SOLH; CAPN15; small optic lobes homolog (Drosophila) |
| Gene Locus | 16p13.3; chromosome 16 |
| GO Function | Not available |
* Information From OMIM
Text: The Drosophila small optic lobes (sol) gene encodes a protein with zinc finger-like repeats, a calpain (see OMIM:114240)-like protease domain, and a C-terminal region of unknown function. Mutations in sol cause a severe reduction in the cell numbers of the neuropiles of the medulla and lobula complexes of the adult optic lobes. Banfi et al. (1996) identified a human EST encoding a protein with homology to the sol gene product. By screening human brain cDNA libraries with this EST, Kamei et al. (1998) isolated cDNAs corresponding to the complete coding sequence of SOLH. The predicted 1,086-amino acid protein shares 44% sequence identity with sol. The calpain-like domain and C-terminal region are highly conserved between SOLH and sol, and similar zinc fingers are present in the N-terminal regions of these proteins. The SOLH gene contains at least 14 exons distributed over more than 45 kb. Southern blot analysis indicated that SOLH is a single-copy gene. Using Northern blots, the authors demonstrated that SOLH is expressed as an approximately 5-kb mRNA in various human tissues; additional smaller transcripts were observed in some tissues. Kamei et al. (1998) identified cDNAs and genomic clones encoding mouse, C. elegans, and Fugu rubripes (Japanese pufferfish) homologs of sol.
* Structure Information
1. Primary Information
Length: 1086 aa
Average Mass: 117.314 kDa
Monoisotopic Mass: 117.239 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| zf-RanBP 1. | 3 | 32 | 17.4 | 0.0081 |
| zf-RanBP 2. | 43 | 73 | 13.6 | 0.025 |
| zf-RanBP 3. | 143 | 172 | 26.8 | 8.6e-05 |
| zf-RanBP 4. | 340 | 369 | 19.5 | 0.0044 |
| zf-RanBP 5. | 412 | 441 | 35.4 | 2.3e-07 |
| Peptidase_C2 1. | 488 | 793 | 454.4 | 1.7e-133 |
| AraC_binding 1. | 939 | 1061 | -26.4 | 6.3 |
3. Sequence Information
Fasta Sequence: CL0893.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 11157797] Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR, Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Hum Mol Genet. 2001 Feb 15;10(4):339-52.