CL0905 : calpain 7
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | calpain like protease; homolog of Aspergillus Nidulans PALB; calpain 7 [Homo sapiens]; Calpain 7 |
| Gene Names | CAPN7; calpain 7 |
| Gene Locus | 3p24; chromosome 3 |
| GO Function | Not available |
* Information From OMIM
Text: Calpain is an intracellular, nonlysosomal cysteine protease whose activity is regulated by calcium. Micro- and millicalpains (CAPN1, OMIM:114220, and CAPN2, OMIM:114230, respectively), which differ in their calcium requirements for protease activity, are ubiquitously expressed. Other calpains are expressed in specific tissues, such as CAPN3 (OMIM:114240) and CAPN9 (OMIM:606401), which are predominant in skeletal muscle and gastrointestinal tissue, respectively (Huang and Wang, 2001).
* Structure Information
1. Primary Information
Length: 813 aa
Average Mass: 92.652 kDa
Monoisotopic Mass: 92.594 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| MIT 1. | 6 | 71 | 56.2 | 1.3e-13 |
| MIT 2. | 86 | 154 | 64.4 | 4.1e-16 |
| Peptidase_C2 1. | 246 | 537 | 3.4 | 3.4e-14 |
| Sklp_toxin 1. | 565 | 634 | -13.6 | 9.7 |
| Calpain_III 1. | 685 | 810 | -20.9 | 2.2e-05 |
3. Sequence Information
Fasta Sequence: CL0905.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 11342116] Futai E, Kubo T, Sorimachi H, Suzuki K, Maeda T, Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9.