CL0892 : calpain 1
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | large subunit; calcium-activated neutral proteinase; calpain; large polypeptide L1; cell proliferation-inducing protein 30; calpain 1, large subunit [Homo sapiens]; Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain; Cell proliferation-inducing gene 30 protein |
| Gene Names | CAPN1; PIG30; CANPL1; calpain 1, (mu/I) large subunit |
| Gene Locus | 11q13; chromosome 11 |
| GO Function | Not available |
* Information From OMIM
Description: Calpain (calcium-dependent protease; EC 3.4.22.17) is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, CANP1 and CANP2, with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit (CAPNS1; OMIM:114170), with the differences arising from the L subunits, L1 (CAPN1) and L2 (CAPN2; OMIM:114230).
* Structure Information
1. Primary Information
Length: 714 aa
Average Mass: 81.890 kDa
Monoisotopic Mass: 81.838 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 55 | 354 | 814.6 | 6.2e-242 |
| Calpain_III 1. | 365 | 522 | 386.7 | 4.1e-113 |
| efhand 1. | 546 | 573 | 1.1 | 16 |
| efhand 2. | 589 | 617 | 16.6 | 0.11 |
| efhand 3. | 619 | 647 | 18.5 | 0.028 |
| efhand 4. | 684 | 711 | 6.2 | 4.5 |
3. Sequence Information
Fasta Sequence: CL0892.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* References
[PubMed ID: 18806756] Norberg E, Gogvadze V, Ott M, Horn M, Uhlen P, Orrenius S, Zhivotovsky B, An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ. 2008 Dec;15(12):1857-64. Epub 2008 Sep 19.