CL0894 : calpain 9 isoform 1
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | novel calpain large subunit-4; calpain 9 isoform 1 [Homo sapiens]; Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36 |
| Gene Names | CAPN9; NCL4; calpain 9 |
| Gene Locus | 1q42.11-q42.3; chromosome 1 |
| GO Function | Not available |
* Information From OMIM
Text: Calpain is an intracellular, nonlysosomal cysteine protease whose activity is regulated by calcium. Micro- and millicalpains (CAPN1, OMIM:114220, and CAPN2, OMIM:114230, respectively), which differ in their calcium requirements for protease activity, are ubiquitously expressed. Other calpains are expressed in specific tissues, such as CAPN3 (OMIM:114240), which is predominant in skeletal muscle. Many gene products associated with carcinogenesis are substrates of calpain family enzymes, including FOS (OMIM:164810), JUN (OMIM:165160), p53 (OMIM:191170), and ESR1 (OMIM:133430) (Huang and Wang, 2001).
* Structure Information
1. Primary Information
Length: 690 aa
Average Mass: 79.097 kDa
Monoisotopic Mass: 79.047 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 42 | 337 | 642.1 | 5.4e-190 |
| Calpain_III 1. | 348 | 494 | 355.0 | 1.4e-103 |
| NUC153 1. | 520 | 551 | -3.4 | 3.6 |
| efhand 1. | 565 | 593 | 27.2 | 6.9e-05 |
| efhand 2. | 595 | 623 | 21.6 | 0.0032 |
3. Sequence Information
Fasta Sequence: CL0894.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* References
[PubMed ID: 17157313] Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S, The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol. 2007 Feb 9;366(1):216-29. Epub 2006 Nov 14.