logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0946 : calpain 12

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain 12 [Homo sapiens]; Calpain-12; 3.4.22.-
Gene NamesCAPN12; calpain 12
Gene Locus19q13.2; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_653292 NM_144691 147968 Q6ZSI9 608839 13249 N/A hsa:147968

* Information From OMIM

Description: Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000). CAPN12 belongs to the calpain large subunit family.

* Structure Information

1. Primary Information

Length: 719 aa

Average Mass: 81.037 kDa

Monoisotopic Mass: 80.985 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
PsbJ 1. 1393.15.5
Peptidase_C2 1. 45341511.11.4e-150
Calpain_III 1. 353528133.09.6e-37
efhand 1. 62465221.50.0035

3. Sequence Information

Fasta Sequence: CL0946.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 10964513] Dear TN, Meier NT, Hunn M, Boehm T, Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. Genomics. 2000 Sep 1;68(2):152-60.