CaMPDB :: Calpain

CL0891 : calpain 5

* Basic Information

Organism	Homo sapiens (human)
Protein Names	calpain 5 [Homo sapiens]; Calpain-5; 3.4.22.-; New calpain 3; nCL-3; htra-3
Gene Names	CAPN5; NCL3; calpain 5
Gene Locus	11q14; chromosome 11
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_004046	NM_004055	726	O15484	602537	1482	N/A	hsa:726

* Information From OMIM

Description: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit (OMIM:114170) and 1 of a family of large subunits.

* Structure Information

1. Primary Information

Length: 640 aa

Average Mass: 73.169 kDa

Monoisotopic Mass: 73.123 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	26	343	435.9	6.4e-128
Calpain_III 1.	353	496	275.2	1.5e-79
C2 1.	519	596	54.7	3.4e-13

3. Sequence Information

Fasta Sequence: CL0891.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18787380] Hidalgo M, Saez ME, Martinez-Tello FJ, Moron FJ, Ferrero-Herrero E, Labalde-Martinez M, Rigopoulou D, Ballestin-Carcavilla C, Ruiz A, Royo JL, Ramirez-Lorca R, Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma. J Endocrinol Invest. 2008 Jul;31(7):618-23.

» More (9) « Hide Below

[PubMed ID: 18657264] ... Saez ME, Grilo A, Moron FJ, Manzano L, Martinez-Larrad MT, Gonzalez-Perez A, Serrano-Hernando J, Ruiz A, Ramirez-Lorca R, Serrano-Rios M, Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. Cardiovasc Diabetol. 2008 Jul 25;7:23.

[PubMed ID: 17227582] ... Saez ME, Martinez-Larrad MT, Ramirez-Lorca R, Gonzalez-Sanchez JL, Zabena C, Martinez-Calatrava MJ, Gonzalez A, Moron FJ, Ruiz A, Serrano-Rios M, Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. BMC Med Genet. 2007 Jan 16;8:1.

[PubMed ID: 16396936] ... Gonzalez A, Saez ME, Aragon MJ, Galan JJ, Vettori P, Molina L, Rubio C, Real LM, Ruiz A, Ramirez-Lorca R, Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. Hum Reprod. 2006 Apr;21(4):943-51. Epub 2006 Jan 5.

[PubMed ID: 15464980] ... Waghray A, Wang DS, McKinsey D, Hayes RL, Wang KK, Molecular cloning and characterization of rat and human calpain-5. Biochem Biophys Res Commun. 2004 Nov 5;324(1):46-51.

[PubMed ID: 11517927] ... Sato K, Kawashima S, Calpain function in the modulation of signal transduction molecules. Biol Chem. 2001 May;382(5):743-51.

[PubMed ID: 11168679] ... Vanderklish PW, Bahr BA, The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states. Int J Exp Pathol. 2000 Oct;81(5):323-39.

[PubMed ID: 9503024] ... Matena K, Boehm T, Dear N, Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. Genomics. 1998 Feb 15;48(1):117-20.

[PubMed ID: 9367857] ... Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M, Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. Biochem Biophys Res Commun. 1997 Oct 29;239(3):845-50.

[PubMed ID: 9339374] ... Dear N, Matena K, Vingron M, Boehm T, A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84.