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CL0004 : Chain L, Crystal Structure Of Human M-Calpain Form Ii

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCalpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; Calpain large polypeptide L2
Gene NamesCANPL2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1KFU_L N/A N/A P17655 N/A N/A N/A hsa:824

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 699 aa

Average Mass: 79.875 kDa

Monoisotopic Mass: 79.825 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 44343808.06.2e-240
Calpain_III 1. 354509393.63.4e-115
efhand 1. 57560320.40.0074
efhand 2. 60563319.40.015
efhand 3. 6706984.07.6

3. Sequence Information

Fasta Sequence: CL0004.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; L=1-700), 1KFX (X-ray; 315 A; L=1-700), 2NQA (X-ray; 220 A; A=43-346)

* References

[PubMed ID: 10666632] Masumoto H, Nakagawa K, Irie S, Sorimachi H, Suzuki K, Bourenkov GP, Bartunik H, Fernandez-Catalan C, Bode W, Strobl S, Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain. Acta Crystallogr D Biol Crystallogr. 2000 Jan;56(Pt 1):73-5.

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