CaMPDB :: Calpain

CL0010 : Chain A, Crystal Structure Of A Mu-Like Calpain

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain
Gene Names	Capn2
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
1QXP_A	N/A	N/A	Q07009	N/A	N/A	N/A	rno:29154

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 900 aa

Average Mass: 103.383 kDa

Monoisotopic Mass: 103.318 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	45	344	754.2	9.3e-224
Calpain_III 1.	355	511	365.0	1.4e-106
efhand 1.	578	606	16.6	0.11
efhand 2.	608	636	18.5	0.027
efhand 3.	673	700	3.2	9.5
efhand 4.	775	803	18.4	0.03
efhand 5.	805	833	7.9	2.9
efhand 6.	870	897	7.5	3.2

3. Sequence Information

Fasta Sequence: CL0010.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DF0 (X-ray; 260 A; A=1-700), 1MDW (X-ray; 195 A; A/B=19-346), 1QXP (X-ray; 280 A; A/B=-), 1U5I (X-ray; 286 A; A=1-700)

* References

[PubMed ID: 14656436] Pal GP, De Veyra T, Elce JS, Jia Z, Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement. Structure. 2003 Dec;11(12):1521-6.