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CL0012 : Chain A, High Resolution Crystal Structure Of Calpain I Protease Core In Complex With Leupeptin

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesCalpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain
Gene NamesCls1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1TL9_A N/A N/A P97571 N/A N/A N/A rno:29153

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 339 aa

Average Mass: 38.760 kDa

Monoisotopic Mass: 38.735 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 30329761.65.6e-226

3. Sequence Information

Fasta Sequence: CL0012.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KXR (X-ray; 207 A; A/B=27-356), 1QXP (X-ray; 280 A; A/B=13-711), 1TL9 (X-ray; 180 A; A=27-356), 1TLO (X-ray; 190 A; A=27-356), 2G8E (X-ray; 225 A; A=27-356), 2G8J (X-ray; 161 A; A=27-356), 2NQG (X-ray; 204 A; A=26-356), 2NQI (X-ray; 204 A; A=26-356)

* References

[PubMed ID: 11893336] Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL, A Ca(2+) switch aligns the active site of calpain. Cell. 2002 Mar 8;108(5):649-60.

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