CaMPDB :: Calpain

CL0014 : Chain A, Crystal Structure Analysis Of Rat M-Calpain Mutant Lys10 Thr

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain
Gene Names	Capn2
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
1U5I_A	N/A	N/A	Q07009	N/A	N/A	N/A	rno:29154

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 79.876 kDa

Monoisotopic Mass: 79.826 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	45	344	802.7	2.3e-238
Calpain_III 1.	355	510	385.6	8.7e-113
efhand 1.	576	604	20.4	0.0074
efhand 2.	606	634	19.4	0.015
efhand 3.	671	698	3.2	9.5

3. Sequence Information

Fasta Sequence: CL0014.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DF0 (X-ray; 260 A; A=1-700), 1MDW (X-ray; 195 A; A/B=19-346), 1QXP (X-ray; 280 A; A/B=-), 1U5I (X-ray; 286 A; A=1-700)

* References

[PubMed ID: 15476820] Hosfield CM, Elce JS, Jia Z, Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides. J Mol Biol. 2004 Oct 29;343(4):1049-53.