CaMPDB :: Calpain

CL0021 : Chain B, Catalytic Domain Of Human Calpain-1

* Basic Information

Organism	Homo sapiens (human)
Protein Names	Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain; Cell proliferation-inducing gene 30 protein
Gene Names	PIG30; CANPL1
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
2ARY_B	N/A	N/A	P07384	N/A	N/A	N/A	hsa:823

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 351 aa

Average Mass: 39.532 kDa

Monoisotopic Mass: 39.507 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	46	345	814.6	6.2e-242

3. Sequence Information

Fasta Sequence: CL0021.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ZCM (X-ray; 200 A; A=33-353), 2ARY (X-ray; 240 A; A/B=27-360)

* References

[PubMed ID: 17157313] Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S, The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol. 2007 Feb 9;366(1):216-29. Epub 2006 Nov 14.