CaMPDB :: Calpain

CL0022 : Chain A, Calpain 1 Proteolytic Core In Complex With Snj-1715, A Cyclic Hemiacetal-Type Inhibitor

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain
Gene Names	Cls1
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
2G8E_A	N/A	N/A	P97571	N/A	N/A	N/A	rno:29153

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 339 aa

Average Mass: 38.760 kDa

Monoisotopic Mass: 38.735 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	30	329	761.6	5.6e-226

3. Sequence Information

Fasta Sequence: CL0022.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KXR (X-ray; 207 A; A/B=27-356), 1QXP (X-ray; 280 A; A/B=13-711), 1TL9 (X-ray; 180 A; A=27-356), 1TLO (X-ray; 190 A; A=27-356), 2G8E (X-ray; 225 A; A=27-356), 2G8J (X-ray; 161 A; A=27-356), 2NQG (X-ray; 204 A; A=26-356), 2NQI (X-ray; 204 A; A=26-356)

* References

[PubMed ID: 16768440] Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL, Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography. Biochemistry. 2006 Jun 20;45(24):7446-52.