CaMPDB :: Calpain

CL0038 : neutral protease large subunit

* Basic Information

Organism	Homo sapiens (human)
Protein Names	Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; Calpain large polypeptide L2
Gene Names	CANP; CANPL2
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
AAA35645	N/A	N/A	P17655	N/A	N/A	N/A	hsa:824

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 80.006 kDa

Monoisotopic Mass: 79.956 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	45	344	808.0	6.2e-240
Calpain_III 1.	355	510	393.6	3.4e-115
efhand 1.	576	604	20.4	0.0074
efhand 2.	606	634	19.4	0.015
efhand 3.	671	699	4.0	7.6

3. Sequence Information

Fasta Sequence: CL0038.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; L=1-700), 1KFX (X-ray; 315 A; L=1-700), 2NQA (X-ray; 220 A; A=43-346)

* References

[PubMed ID: 2852952] Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K, Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease. Biochemistry. 1988 Oct 18;27(21):8122-8.