CaMPDB :: Calpain

CL0046 : calcium-dependent cysteine proteinase [Homo sapiens]

* Basic Information

Organism	Homo sapiens (human)
Protein Names	calcium-dependent cysteine proteinase; Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36
Gene Names	nCL-4; NCL4
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
AAB80762	N/A	N/A	O14815	N/A	N/A	N/A	hsa:10753

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 690 aa

Average Mass: 79.097 kDa

Monoisotopic Mass: 79.047 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	42	337	642.1	5.4e-190
Calpain_III 1.	348	494	355.0	1.4e-103
NUC153 1.	520	551	-3.4	3.6
efhand 1.	565	593	27.2	6.9e-05
efhand 2.	595	623	21.6	0.0032

3. Sequence Information

Fasta Sequence: CL0046.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ZIV (X-ray; 231 A; A=26-347), 2P0R (X-ray; 250 A; A/B=10-340)

* References

[PubMed ID: 9524069] Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K, Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83.