CaMPDB :: Calpain

CL0061 : mu-calpain large subunit

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain
Gene Names	cls1; Cls1
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
AAC53001	N/A	N/A	P97571	N/A	N/A	N/A	rno:29153

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 713 aa

Average Mass: 82.119 kDa

Monoisotopic Mass: 82.067 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	55	354	761.6	5.6e-226
Calpain_III 1.	365	521	365.0	1.4e-106
efhand 1.	588	616	16.6	0.11
efhand 2.	618	646	18.5	0.027
efhand 3.	683	710	7.2	3.5

3. Sequence Information

Fasta Sequence: CL0061.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KXR (X-ray; 207 A; A/B=27-356), 1QXP (X-ray; 280 A; A/B=13-711), 1TL9 (X-ray; 180 A; A=27-356), 1TLO (X-ray; 190 A; A=27-356), 2G8E (X-ray; 225 A; A=27-356), 2G8J (X-ray; 161 A; A=27-356), 2NQG (X-ray; 204 A; A=26-356), 2NQI (X-ray; 204 A; A=26-356)

* References

[PubMed ID: 8950173] Sorimachi H, Amano S, Ishiura S, Suzuki K, Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human. Biochim Biophys Acta. 1996 Nov 11;1309(1-2):37-41.