logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0114 : calpain large polypeptide L2

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain large polypeptide L2 [Homo sapiens]; Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; Calpain large polypeptide L2
Gene NamesCANPL2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAF99682 N/A N/A P17655 N/A N/A N/A hsa:824

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 79.934 kDa

Monoisotopic Mass: 79.884 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 45344814.28.4e-242
Calpain_III 1. 355510393.63.4e-115
efhand 1. 57660420.40.0074
efhand 2. 60663419.40.015
efhand 3. 6716994.07.6

3. Sequence Information

Fasta Sequence: CL0114.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; L=1-700), 1KFX (X-ray; 315 A; L=1-700), 2NQA (X-ray; 220 A; A=43-346)

* References

[PubMed ID: 10944468] Ye Z, Connor JR, cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. Biochem Biophys Res Commun. 2000 Aug 18;275(1):223-7.