CL0131 : calpain 6
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Calpain 6 [Homo sapiens]; Calpain-6; Calpamodulin; CalpM; Calpain-like protease X-linked |
| Gene Names | CAPN6; CALPM, CANPX; CALPM; CANPX |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Text: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit (OMIM:114170) and 1 of a family of large subunits. Dear et al. (1997) used degenerate PCR on mouse genomic DNA to isolate fragments of 2 novel calpains, CAPN5 (OMIM:602537) and CAPN6. The authors assembled a partial cDNA sequence of CAPN6 from several clones in an EST database. Dear et al. (1997) noted that CAPN5 and CAPN6 differ from previously identified vertebrate calpains in that they lack a calmodulin-like domain IV. CAPN6 may be an atypical calpain because it contains only 1 of the 3 conserved cysteine protease active site residues. By RNA dot blot and Northern blot analyses, Dear et al. (1997) found that CAPN6 is expressed as a 4.0-kb transcript predominantly in placenta.
* Structure Information
1. Primary Information
Length: 641 aa
Average Mass: 74.576 kDa
Monoisotopic Mass: 74.529 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 26 | 344 | 283.3 | 5.6e-82 |
| Calpain_III 1. | 350 | 495 | 274.2 | 2.9e-79 |
| C2 1. | 518 | 597 | 55.0 | 2.8e-13 |
3. Sequence Information
Fasta Sequence: CL0131.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.