CL0134 : calpain 10
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Calpain 10 [Homo sapiens]; Calpain-10; 3.4.22.-; Calcium-activated neutral proteinase 10; CANP 10 |
| Gene Names | CAPN10; KIAA1845 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Function: The results of Horikawa et al. (2000) suggested a novel pathway involved in the pathophysiology of diabetes, one that may include, in addition to calpain-10, its substrates, inhibitors, and activators. Calpain-10 may represent the third example of a protease contributing to the development of diabetes, the others being prohormone-processing carboxypeptidase E (OMIM:114855) and prohormone convertase-1 (OMIM:162150), both of which are associated with diabetes and obesity.
* Structure Information
1. Primary Information
Length: 672 aa
Average Mass: 74.938 kDa
Monoisotopic Mass: 74.891 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 13 | 316 | 182.5 | 1.2e-51 |
| Calpain_III 1. | 338 | 494 | 31.4 | 1.8e-09 |
| Calpain_III 2. | 513 | 645 | 14.8 | 3.6e-08 |
3. Sequence Information
Fasta Sequence: CL0134.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.