CL0140 : calpain 1
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | (mu/I) large subunit; Calpain 1, (mu/I) large subunit [Homo sapiens]; Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain; Cell proliferation-inducing gene 30 protein |
| Gene Names | CAPN1; PIG30; CANPL1 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Description: Calpain (calcium-dependent protease; EC 3.4.22.17) is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, CANP1 and CANP2, with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit (CAPNS1; OMIM:114170), with the differences arising from the L subunits, L1 (CAPN1) and L2 (CAPN2; OMIM:114230).
* Structure Information
1. Primary Information
Length: 714 aa
Average Mass: 81.890 kDa
Monoisotopic Mass: 81.838 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 55 | 354 | 814.6 | 6.2e-242 |
| Calpain_III 1. | 365 | 522 | 386.7 | 4.1e-113 |
| efhand 1. | 546 | 573 | 1.1 | 16 |
| efhand 2. | 589 | 617 | 16.6 | 0.11 |
| efhand 3. | 619 | 647 | 18.5 | 0.028 |
| efhand 4. | 684 | 711 | 6.2 | 4.5 |
3. Sequence Information
Fasta Sequence: CL0140.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.