CL0145 : CAPN9 protein
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | CAPN9 protein [Homo sapiens]; Calpain 9, isoform CRA_a |
| Gene Names | CAPN9; hCG_15929 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Text: Calpain is an intracellular, nonlysosomal cysteine protease whose activity is regulated by calcium. Micro- and millicalpains (CAPN1, OMIM:114220, and CAPN2, OMIM:114230, respectively), which differ in their calcium requirements for protease activity, are ubiquitously expressed. Other calpains are expressed in specific tissues, such as CAPN3 (OMIM:114240), which is predominant in skeletal muscle. Many gene products associated with carcinogenesis are substrates of calpain family enzymes, including FOS (OMIM:164810), JUN (OMIM:165160), p53 (OMIM:191170), and ESR1 (OMIM:133430) (Huang and Wang, 2001).
* Structure Information
1. Primary Information
Length: 627 aa
Average Mass: 72.310 kDa
Monoisotopic Mass: 72.264 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 42 | 274 | 380.0 | 4.2e-111 |
| Calpain_III 1. | 285 | 431 | 355.0 | 1.4e-103 |
| NUC153 1. | 457 | 488 | -3.4 | 3.6 |
| efhand 1. | 502 | 530 | 27.2 | 6.9e-05 |
| efhand 2. | 532 | 560 | 21.6 | 0.0032 |
3. Sequence Information
Fasta Sequence: CL0145.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.