CaMPDB :: Calpain

CL0897 : calpain 1

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	large subunit; mu-calpain; calpain 1, large subunit [Mus musculus]; Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain
Gene Names	Capn1; Canp1, Capa1; Canp1; Capa1; calpain 1
Gene Locus	19 3.0 cM; chromosome 19
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_031626	NM_007600	12333	O35350	N/A	N/A	N/A	mmu:12333

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 713 aa

Average Mass: 82.106 kDa

Monoisotopic Mass: 82.054 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	55	354	756.7	1.6e-224
Calpain_III 1.	365	521	364.9	1.5e-106
efhand 1.	588	616	16.6	0.11
efhand 2.	618	646	18.5	0.027
efhand 3.	683	710	7.5	3.2

3. Sequence Information

Fasta Sequence: CL0897.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 19036965] Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA, Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity. J Neurosci. 2008 Nov 26;28(48):12725-35.

» More (9) « Hide Below

[PubMed ID: 17977825] ... Darnell GA, Schroder WA, Antalis TM, Lambley E, Major L, Gardner J, Birrell G, Cid-Arregui A, Suhrbier A, Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. J Biol Chem. 2007 Dec 28;282(52):37492-500. Epub 2007 Oct 31.

[PubMed ID: 18052987] ... Touma E, Kato S, Fukui K, Koike T, Calpain-mediated cleavage of collapsin response mediator protein(CRMP)-2 during neurite degeneration in mice. Eur J Neurosci. 2007 Dec;26(12):3368-81. Epub 2007 Dec 4.

[PubMed ID: 17826176] ... To KC, Church J, O'Connor TP, Combined activation of calpain and calcineurin during ligand-induced growth cone collapse. Mol Cell Neurosci. 2007 Dec;36(4):425-34. Epub 2007 Aug 9.

[PubMed ID: 17804406] ... Chen BB, Mallampalli RK, Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. J Biol Chem. 2007 Nov 16;282(46):33494-506. Epub 2007 Sep 5.

[PubMed ID: 8997499] ... Sorimachi H, Forsberg NE, Lee HJ, Joeng SY, Richard I, Beckmann JS, Ishiura S, Suzuki K, Highly conserved structure in the promoter region of the gene for muscle-specific calpain, p94. Biol Chem. 1996 Dec;377(12):859-64.

[PubMed ID: 8806430] ... Spencer MJ, Tidball JG, Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice. Exp Cell Res. 1996 Aug 1;226(2):264-72.

[PubMed ID: 8738748] ... Li J, Grynspan F, Berman S, Nixon R, Bursztajn S, Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord. J Neurobiol. 1996 Jun;30(2):177-91.

[PubMed ID: 2209092] ... Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K, Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9.

[PubMed ID: 2209090] ... Moens PB, Pearlman RE, In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes. Cytogenet Cell Genet. 1990;53(4):219-20.