CaMPDB :: Calpain

CL0900 : calpain 6

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	calpain 6 [Mus musculus]; Calpain 6
Gene Names	Capn6; calpain 6
Gene Locus	Not available
GO Function	GO:0004198 - calpain activity [Evidence IEA]; GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_031629	NM_007603	12338	Q80VZ1	N/A	N/A	N/A	mmu:12338

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 641 aa

Average Mass: 74.577 kDa

Monoisotopic Mass: 74.529 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	26	344	259.6	7.5e-75
Calpain_III 1.	350	495	278.0	2.1e-80
C2 1.	518	597	53.4	8.5e-13

3. Sequence Information

Fasta Sequence: CL0900.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 17210638] Tonami K, Kurihara Y, Aburatani H, Uchijima Y, Asano T, Kurihara H, Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. Mol Cell Biol. 2007 Apr;27(7):2548-61. Epub 2007 Jan 8.

» More (9) « Hide Below

[PubMed ID: 15561968] ... Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF, Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36.

[PubMed ID: 15242968] ... Masino AM, Gallardo TD, Wilcox CA, Olson EN, Williams RS, Garry DJ, Transcriptional regulation of cardiac progenitor cell populations. Circ Res. 2004 Aug 20;95(4):389-97. Epub 2004 Jul 8.

[PubMed ID: 14743444] ... Hedlund E, Karsten SL, Kudo L, Geschwind DH, Carpenter EM, Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. J Neurosci Res. 2004 Feb 1;75(3):307-19.

[PubMed ID: 11044609] ... Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94.

[PubMed ID: 10559499] ... Dear TN, Boehm T, Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Mech Dev. 1999 Dec;89(1-2):201-9.

[PubMed ID: 9503024] ... Matena K, Boehm T, Dear N, Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. Genomics. 1998 Feb 15;48(1):117-20.

[PubMed ID: 9473662] ... Li J, Nixon R, Messer A, Berman S, Bursztajn S, Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord. Brain Res Mol Brain Res. 1998 Jan;53(1-2):174-86.

[PubMed ID: 9396712] ... Sorimachi H, Ishiura S, Suzuki K, Structure and physiological function of calpains. Biochem J. 1997 Dec 15;328 ( Pt 3):721-32.

[PubMed ID: 9339374] ... Dear N, Matena K, Vingron M, Boehm T, A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84.