CaMPDB :: Calpain

CL0901 : calpain 2

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	cysteine proteinase; m-calpain 80 kDa large subunit; m-calpain large subunit; calpain 2 [Mus musculus]; Calpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; 80 kDa M-calpain subunit; CALP80
Gene Names	Capn2; calpain 2
Gene Locus	Not available
GO Function	GO:0004198 - calpain activity [Evidence TAS]; GO:0016787 - hydrolase activity [Evidence IEA]; GO:0008233 - peptidase activity [Evidence IEA]; GO:0005509 - calcium ion binding [Evidence IEA]; GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_033924	NM_009794	12334	O08529	N/A	N/A	N/A	mmu:12334

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 79.858 kDa

Monoisotopic Mass: 79.808 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	45	344	807.0	1.2e-239
Calpain_III 1.	355	510	384.7	1.6e-112
efhand 1.	576	604	20.4	0.0074
efhand 2.	606	634	19.4	0.015
efhand 3.	671	698	1.8	13

3. Sequence Information

Fasta Sequence: CL0901.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 17541403] Wu Y, Liang S, Oda Y, Ohmori I, Nishiki T, Takei K, Matsui H, Tomizawa K, Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitation. EMBO J. 2007 Jun 20;26(12):2981-90. Epub 2007 May 31.

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[PubMed ID: 16809781] ... Shao H, Chou J, Baty CJ, Burke NA, Watkins SC, Stolz DB, Wells A, Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Mol Cell Biol. 2006 Jul;26(14):5481-96.

[PubMed ID: 16632474] ... Tan Y, Wu C, De Veyra T, Greer PA, Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli. J Biol Chem. 2006 Jun 30;281(26):17689-98. Epub 2006 Apr 21.

[PubMed ID: 16723743] ... Calle Y, Carragher NO, Thrasher AJ, Jones GE, Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J Cell Sci. 2006 Jun 1;119(Pt 11):2375-85.

[PubMed ID: 16971167] ... Leloup L, Mazeres G, Daury L, Cottin P, Brustis JJ, Involvement of calpains in growth factor-mediated migration. Int J Biochem Cell Biol. 2006;38(12):2049-63. Epub 2006 May 17.

[PubMed ID: 9396712] ... Sorimachi H, Ishiura S, Suzuki K, Structure and physiological function of calpains. Biochem J. 1997 Dec 15;328 ( Pt 3):721-32.

[PubMed ID: 9339374] ... Dear N, Matena K, Vingron M, Boehm T, A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84.

[PubMed ID: 8806430] ... Spencer MJ, Tidball JG, Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice. Exp Cell Res. 1996 Aug 1;226(2):264-72.

[PubMed ID: 8738748] ... Li J, Grynspan F, Berman S, Nixon R, Bursztajn S, Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord. J Neurobiol. 1996 Jun;30(2):177-91.

[PubMed ID: 2209092] ... Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K, Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9.