CaMPDB :: Calpain

CL0903 : calpain 10

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	calpain 8; calpain 10 [Mus musculus]; Calpain-10; 3.4.22.-; Calcium-activated neutral proteinase 10; CANP 10
Gene Names	Capn10; Capn8; calpain 10
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_035926	NM_011796	23830	Q9ESK3	N/A	N/A	N/A	mmu:23830

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 666 aa

Average Mass: 74.596 kDa

Monoisotopic Mass: 74.549 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	13	322	204.3	3.3e-58
Calpain_III 1.	338	488	52.0	2.3e-12
Calpain_III 2.	507	639	3.2	2.9e-07

3. Sequence Information

Fasta Sequence: CL0903.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18054326] Giguere CJ, Covington MD, Schnellmann RG, Mitochondrial calpain 10 activity and expression in the kidney of multiple species. Biochem Biophys Res Commun. 2008 Feb 1;366(1):258-62. Epub 2007 Dec 3.

» More (9) « Hide Below

[PubMed ID: 17339028] ... Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H, BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab. 2007 Mar;5(3):207-19.

[PubMed ID: 16783635] ... Kenney-Hunt JP, Vaughn TT, Pletscher LS, Peripato A, Routman E, Cothran K, Durand D, Norgard E, Perel C, Cheverud JM, Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37. Epub 2006 Jun 12.

[PubMed ID: 15561968] ... Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF, Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36.

[PubMed ID: 15044459] ... Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS, RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem. 2004 Jun 4;279(23):24794-802. Epub 2004 Mar 25.

[PubMed ID: 12634108] ... Reed NA, Castellini MA, Ma H, Shearer TR, Duncan MK, Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Exp Eye Res. 2003 Apr;76(4):433-43.

[PubMed ID: 11812828] ... Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH, Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Nucleic Acids Res. 2001 Dec 15;29(24):4983-93.

[PubMed ID: 11017071] ... Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI, Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000 Oct;26(2):163-75.

[PubMed ID: 10964513] ... Dear TN, Meier NT, Hunn M, Boehm T, Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. Genomics. 2000 Sep 1;68(2):152-60.

[PubMed ID: 10403824] ... Braun C, Engel M, Theisinger B, Welter C, Seifert M, CAPN 8: isolation of a new mouse calpain-isoenzyme. Biochem Biophys Res Commun. 1999 Jul 14;260(3):671-5.