CL0943 : calpain 8
[ CaMP Format ]
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | novel Calpain Large subunit; cysteine protease; tissue-specific calpain 2; calpain 8 [Rattus norvegicus]; Calpain-8; 3.4.22.53; Stomach-specific M-type calpain; New calpain 2; nCL-2; Calpain large subunit 4 |
| Gene Names | Capn8; Cls4, Ncl2; Cls4; Ncl2; calpain 8 |
| Gene Locus | 13q26; chromosome 13 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_579843 | NM_133309 | 170808 | Q78EJ9 | N/A | N/A | N/A | rno:170808 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 703 aa
Average Mass: 79.555 kDa
Monoisotopic Mass: 79.505 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 45 | 344 | 727.1 | 1.4e-215 |
| Calpain_III 1. | 355 | 512 | 366.7 | 4.3e-107 |
| efhand 1. | 536 | 563 | 3.2 | 9.3 |
| efhand 2. | 579 | 607 | 20.7 | 0.006 |
| efhand 3. | 609 | 637 | 20.5 | 0.0068 |
| efhand 4. | 674 | 701 | 4.7 | 6.4 |
3. Sequence Information
Fasta Sequence: CL0943.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 16476741] Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H, Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem. 2006 Apr 21;281(16):11214-24. Epub 2006 Feb 13.