CaMPDB :: Calpain

CL0950 : calpain 1

* Basic Information

Organism	Bos taurus (cattle)
Protein Names	large subunit; micromolar calcium activated neutral protease 1; micromolar calcium-activated neutral protease 1; calpain 1, large subunit [Bos taurus]; Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain
Gene Names	CAPN1; calpain 1, (mu/I) large subunit
Gene Locus	29; chromosome 29
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_776684	NM_174259	281661	Q27970	N/A	N/A	N/A	bta:281661

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 716 aa

Average Mass: 82.207 kDa

Monoisotopic Mass: 82.155 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Peptidase_C2 1.	55	354	796.0	2.4e-236
Calpain_III 1.	365	524	378.2	1.5e-110
efhand 1.	548	575	0.1	20
efhand 2.	591	619	16.6	0.11
efhand 3.	621	649	15.4	0.23
efhand 4.	686	713	6.2	4.5

3. Sequence Information

Fasta Sequence: CL0950.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18682401] Averna M, Stifanese R, De Tullio R, Passalacqua M, Salamino F, Pontremoli S, Melloni E, Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells. J Biol Chem. 2008 Oct 24;283(43):29069-76. Epub 2008 Aug 5.

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[PubMed ID: 18423040] ... Cheong HS, Yoon DH, Park BL, Kim LH, Bae JS, Namgoong S, Lee HW, Han CS, Kim JO, Cheong IC, Shin HD, A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle. BMC Genet. 2008 Apr 19;9:33.

[PubMed ID: 17603104] ... Barendse W, Harrison BE, Hawken RJ, Ferguson DM, Thompson JM, Thomas MB, Bunch RJ, Epistasis between calpain 1 and its inhibitor calpastatin within breeds of cattle. Genetics. 2007 Aug;176(4):2601-10. Epub 2007 Jul 1.

[PubMed ID: 16297652] ... Raynaud F, Jond-Necand C, Marcilhac A, Furst D, Benyamin Y, Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha. Int J Biochem Cell Biol. 2006 Mar;38(3):404-13. Epub 2005 Oct 27.

[PubMed ID: 15885106] ... Raynaud F, Fernandez E, Coulis G, Aubry L, Vignon X, Bleimling N, Gautel M, Benyamin Y, Ouali A, Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril. FEBS J. 2005 May;272(10):2578-90.

[PubMed ID: 15523157] ... Juszczuk-Kubiak E, Sakowski T, Flisikowski K, Wicinska K, Oprzadek J, Rosochacki SJ, Bovine mu-calpain (CAPN1) gene: new SNP within intron 14. J Appl Genet. 2004;45(4):457-60.

[PubMed ID: 14622253] ... Raynaud F, Bonnal C, Fernandez E, Bremaud L, Cerutti M, Lebart MC, Roustan C, Ouali A, Benyamin Y, The calpain 1-alpha-actinin interaction. Resting complex between the calcium-dependent protease and its target in cytoskeleton. Eur J Biochem. 2003 Dec;270(23):4662-70.

[PubMed ID: 12016516] ... Heaton MP, Harhay GP, Bennett GL, Stone RT, Grosse WM, Casas E, Keele JW, Smith TP, Chitko-McKown CG, Laegreid WW, Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle. Mamm Genome. 2002 May;13(5):272-81.

[PubMed ID: 11048924] ... Smith TP, Casas E, Rexroad CE 3rd, Kappes SM, Keele JW, Bovine CAPN1 maps to a region of BTA29 containing a quantitative trait locus for meat tenderness. J Anim Sci. 2000 Oct;78(10):2589-94.

[PubMed ID: 2065086] ... Zimmerman UJ, Schlaepfer WW, Two-stage autolysis of the catalytic subunit initiates activation of calpain I. Biochim Biophys Acta. 1991 Jun 24;1078(2):192-8.