CL1490 : calpain 3
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | (p94); Calpain 3, (p94) [Homo sapiens]; Calpain-3; 3.4.22.54; Calpain L3; Calpain p94; Calcium-activated neutral proteinase 3; CANP 3; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1 |
| Gene Names | CAPN3; CANP3, CANPL3, NCL1; CANP3; CANPL3; NCL1 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Description: The CAPN3 gene encodes calpain-3. The calpains, or calcium-activated neutral proteases (EC 3.4.22.17), are nonlysosomal intracellular cysteine proteases. Mammalian calpains are heterodimers composed of a ubiquitous 80-kD large subunit (e.g., CAPN1, OMIM:114220 and CAPN2, OMIM:114230) and a common small 30-kD subunit (CAPNS1; OMIM:114170). CAPN3 is a muscle-specific large subunit (Sorimachi et al., 1989).
* Structure Information
1. Primary Information
Length: 821 aa
Average Mass: 94.254 kDa
Monoisotopic Mass: 94.194 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 74 | 417 | 942.2 | 2.4e-280 |
| Calpain_III 1. | 428 | 582 | 367.3 | 2.8e-107 |
| Osmo_CC 1. | 643 | 688 | 2.9 | 6 |
| efhand 1. | 696 | 724 | 27.9 | 4e-05 |
| efhand 2. | 726 | 754 | 26.7 | 9.3e-05 |
| efhand 3. | 791 | 818 | 9.1 | 2.2 |
3. Sequence Information
Fasta Sequence: CL1490.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1Y9V (Model; -; A/B=649-821)
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.