CaMPDB :: Substrate

XSB0052 : epidermal growth factor receptor [Xenopus laevis]

This entry is computationally expanded from SB0050

* Basic Information

Organism	Xenopus laevis (African clawed frog)
Protein Names	epidermal growth factor receptor
Gene Names	egfr
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
ABG35749	N/A	N/A	Q153D7	N/A	N/A	N/A	xla:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 789 aa

Average Mass: 87.982 kDa

Monoisotopic Mass: 87.926 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Recep_L_domain 1.	1	67	1.0	0.0034
C1_2 1.	108	142	-0.6	3.9
Toxin_1 1.	146	190	-23.0	1
Adeno_E3_CR2 1.	229	262	-2.1	1.5
PRP4 1.	264	296	-3.5	3.8
--- cleavage 268 (inside PRP4 264..296) ---
Pkinase_Tyr 1.	297	553	433.8	2.7e-127

3. Sequence Information

Fasta Sequence: XSB0052.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] NRKRTLRRIL²⁶⁸-QERELVEPVT

Leu²⁶⁸ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Asn²⁵⁹	Arg²⁶⁰	Lys²⁶¹	Arg²⁶²	Thr²⁶³	Leu²⁶⁴	Arg²⁶⁵	Arg²⁶⁶	Ile²⁶⁷	Leu²⁶⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln²⁶⁹	Glu²⁷⁰	Arg²⁷¹	Glu²⁷²	Leu²⁷³	Val²⁷⁴	Glu²⁷⁵	Pro²⁷⁶	Val²⁷⁷	Thr²⁷⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
ILGAVVIGLVAFFFIRRSRINRKRTLRRILQERELVEPVTPSGEAPNQALLRILKETEFK

Summary

#	organism	max score	hits	top seq
1	Xenopus laevis	116.00	3	epidermal growth factor receptor
2	Sus scrofa	88.60	2	epidermal growth factor receptor
3	Monodelphis domestica	87.80	4	PREDICTED: similar to Epidermal growth factor rece
4	Canis familiaris	87.40	4	epidermal growth factor receptor
5	Bos taurus	87.00	1	PREDICTED: similar to epidermal growth factor rece
6	Tetraodon nigroviridis	86.70	6	unnamed protein product
7	Danio rerio	86.30	6	epidermal growth factor receptor
8	Xiphophorus xiphidium	86.30	2	epidermal growth factor receptor
9	N/A	85.50	24	-
10	Avian erythroblastosis virus	85.50	3	gag,v-erb-A,v-erb-B
11	Rous-associated virus type 1	85.50	2	polyprotein
12	Homo sapiens	85.10	20	unnamed protein product
13	Pan troglodytes	85.10	9	PREDICTED: epidermal growth factor receptor isofor
14	Macaca mulatta	85.10	7	PREDICTED: epidermal growth factor receptor, parti
15	synthetic construct	85.10	3	epidermal growth factor receptor
16	Mus musculus	84.00	10	AF275367_1 epidermal growth factor receptor
17	Rattus norvegicus	83.60	9	epidermal growth factor receptor
18	Xiphophorus sp.	81.60	1	XMRK_XIPMA Melanoma receptor tyrosine-protein kina
19	Canis lupus familiaris	70.90	1	erbB-2
20	Felis catus	69.30	2	v-erb-b2 erythroblastic leukemia viral oncogene ho
21	Gallus gallus	68.90	5	AF121963_1 receptor tyrosine kinase precursor
22	Ovis aries	67.80	1	erythroblastic leukemia viral oncogene-like 2
23	Mesocricetus auratus	67.00	1	ERBB2_MESAU Receptor tyrosine-protein kinase erbB-
24	Pongo pygmaeus	47.80	1	ERBB3_PONPY Receptor tyrosine-protein kinase erbB-
25	Ciona intestinalis	41.60	2	epidermal growth factor receptor
26	Takifugu rubripes	33.50	1	erbB3
27	Strongylocentrotus purpuratus	33.50	1	PREDICTED: similar to v-erb-a erythroblastic leuke
28	Anopheles gambiae	33.10	1	putative epidermal growth factor receptor
29	Anopheles gambiae str. PEST	33.10	1	ENSANGP00000018805

Top-ranked sequences

organism	matching
Xenopus laevis	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298
Sus scrofa	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 649 LLLAVVLALGVGLFLRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 708
Monodelphis domestica	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+\|\| \| \|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 680 LLLLVVLGLGIGLFFRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 739
Canis familiaris	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 43 LLLVVVVALGVGLFLRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 102
Bos taurus	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 631 LLLVVVLALSVGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 690
Tetraodon nigroviridis	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| ++ \|\| \| +\|\| \| \|\|\|\|+\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| Sbjct 624 LLAVLLAGLSVFVLLRRRHIKRKRTMRRLL#QERELVEPLTPSGEAPNQALLRILKEPEFK 683
Danio rerio	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|++ \| +\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 653 LLAFVILALGVAVLLRRRHIRRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 712
Xiphophorus xiphidium	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| ++ \|\| \| \|+\|\| \| \|\|\|\|+\|\|+\|#\|\|\| \|\|\|\|+\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| Sbjct 664 LLAVLIAGLSVFVFLRRRHIKRKRTMRRLL#QERALVEPLTPSGQAPNQALLRILKEPEFK 723
N/A	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+\|\| ++\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 138 LLCLVVVGLGIGLYLRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQAHLRILKETEFK 197
Avian erythroblastosis virus	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+\|\| ++\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 496 LLCLVVVGLGIGLYLRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQAHLRILKETEFK 555
Rous-associated virus type 1	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+\|\| ++\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 228 LLCLVVVGLGIGLYLRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQAHLRILKETEFK 287
Homo sapiens	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| +\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 512 LLLLLVVALGIGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 571
Pan troglodytes	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| +\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 654 LLLLLVVALGIGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 713
Macaca mulatta	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| +\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 654 LLLLLVVALGIGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 713
synthetic construct	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| +\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 654 LLLLLVVALGIGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQALLRILKETEFK 713
Mus musculus	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+ \| \|+\|\| \| \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 656 LLFIVVVALGIGLFMRRRHIVRKRTLRRLL#QERELVEPLTPSGEAPNQAHLRILKETEFK 715
Rattus norvegicus	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|\|+ \| \|+\|\| ++ \|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 655 LLFIVVVALGIGLFMRRRQLVRKRTLRRLL#QERELVEPLTPSGEAPNQAHLRILKETEFK 714
Xiphophorus sp.	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 +\| \|++ \|+ +\|\| \|\| \|\|\|\|+\| +\|#\|\|+\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 652 LLITVIVALLIVVLLRRRRIKRKRTIRCLL#QEKELVEPLTPSGQAPNQAFLRILKETEFK 711
Canis lupus familiaris	Query 239 ILGAVVIGLVAFFFIRRSRIN-RKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEF 297 \|\| \|\|\|+\|\|\| \|+\| \| \|\| \|+\|\|+\|#\|\| \|\|\|\|\|+\|\|\|\| \|\|\|\| +\|\|\|\|\|\|\| Sbjct 660 ILLAVVVGLVLGILIKRRRQKIRKYTMRRLL#QETELVEPLTPSGAMPNQAQMRILKETEL 719 Query 298 K 298 + Sbjct 720 R 720
Felis catus	Query 239 ILGAVVIGLVAFFFIRRSRIN-RKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEF 297 \|\| \|\|+\|\|\| \|+\| \| \|\| \|+\|\|+\|#\|\| \|\|\|\|\|+\|\|\|\| \|\|\|\| +\|\|\|\|\|\|\| Sbjct 661 ILLVVVVGLVLGILIKRRRQKIRKYTMRRLL#QETELVEPLTPSGAMPNQAQMRILKETEL 720 Query 298 K 298 + Sbjct 721 R 721
Gallus gallus	Query 243 VVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 \|++\|\| ++\|\| \| +\|\| \|\|\| \|# \| \|\|\|\|\|+\|\|\|\| \|\|\|\|\| \|\|\|\|\|\|\|\| \| Sbjct 513 VIMGLTFAVYVRRKSIKKKRALRRFL#-ETELVEPLTPSGTAPNQAQLRILKETELK 567
Ovis aries	Query 239 ILGAVVIGLVAFFFIRRSRIN-RKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEF 297 +\| \|++\|\|\| \|+\| \| \|\| \|+\|\|+\|#\|\| \|\|\|\|\|+\|\|\|\| \|\|\|\| +\|\|\|\|\|\|\| Sbjct 12 VLLVVLVGLVLGILIKRRRQKIRKYTMRRLL#QETELVEPLTPSGAMPNQAQMRILKETEL 71 Query 298 K 298 + Sbjct 72 R 72
Mesocricetus auratus	Query 239 ILGAVVIGLVAFFFIRRSRIN-RKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEF 297 \|\| +\|\|\|+\| \|+\| \| \|\| \|+\|\|+\|#\|\| \|\|\|\|\|+\|\|\|\| \|\|\|\| +\|\|\|\|\|\|\| Sbjct 661 ILLFLVIGVVVGILIKRRRQKIRKYTMRRLL#QETELVEPLTPSGAMPNQAQMRILKETEL 720 Query 298 K 298 + Sbjct 721 R 721
Pongo pygmaeus	Query 239 ILGAVVIGLV---AFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKET 295 \| \| \|\|\| ++ \| + \| \|\| \|\| +\|\| \|#+ \| +\|\|+ \|\| \| \|+ \| \|\| \|\|\| Sbjct 649 IAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYL#ERGESIEPLDPS-EKANKVLARIFKET 707 Query 296 EFK 298 \| \| Sbjct 708 ELK 710
Ciona intestinalis	Query 247 LVAFFF---IRRSRINRKRT--LRRI-----------L#QER-ELVEPVTPSGEAPNQALL 289 \| + \|\| \|\| +\| +\|\|\| +\|++ +# \| \|+\|\|+\|\|\|\| \|\|\|\|\| \| Sbjct 56 LFSIFFGCRYRRKQIQKKRTQSMRKLGIDPHSPEEQNM#DPRVRLMEPMTPSGVAPNQAQL 115 Query 290 RILKETEFK 298 \|\|+\|\| \| + Sbjct 116 RIVKEAELR 124
Takifugu rubripes	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 ++ +\|+ + + \| \| \|\|\| +\|\| \|#+ \| \|\|+ \| \|\| + \|\|\|\| ++ + Sbjct 650 LIFCLVLFFLGMLYHRGLAIRRKRAMRRYL#ESGESFEPLGP-GEKGTKVHARILKPSDLR 708
Strongylocentrotus purpuratus	Query 276 PVTPSGEAPNQALLRILKETEFK 298 \|+\|\|\| \|\|\|\| \|+\|+\|+\|\| \| Sbjct 999 PLTPSNVEPNQAQLKIIKDTELK 1021
Anopheles gambiae	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 \|\| \|\| \|+ \| \| + \|# \| \|\|+ \|\| \|\| \|\|\|+\|\| \| + Sbjct 776 ILLCVVFGIAFVLFSRHKNKKDAVKMTMAL#AGCEDSEPLRPSNVGPNLTKLRIIKEAEIR 835
Anopheles gambiae str. PEST	Query 239 ILGAVVIGLVAFFFIRRSRINRKRTLRRIL#QERELVEPVTPSGEAPNQALLRILKETEFK 298 \|\| \|\| \|+ \| \| + \|# \| \|\|+ \|\| \|\| \|\|\|+\|\| \| + Sbjct 777 ILLCVVFGIAFVLFSRHKNKKDAVKMTMAL#AGCEDSEPLRPSNVGPNLTKLRIIKEAEIR 836

* References

[PubMed ID: 16258939] Nie S, Chang C, Regulation of early Xenopus development by ErbB signaling. Dev Dyn. 2006 Feb;235(2):301-14.