XSB0072 : Glucagon
[ CaMP Format ]
This entry is computationally expanded from SB0054
* Basic Information
| Organism | Cavia porcellus (domestic guinea pig) |
| Protein Names | GRPP; OXY; OXM; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2; Glicentin; Glicentin-related polypeptide; Oxyntomodulin; Glucagon-like peptide 1; Glucagon-like peptide 1(7-37); Glucagon-like peptide 1(7-36); Glucagon-like peptide 2; Contains: RecName: Full=Glicentin; Contains: RecName: Full=Glicentin-related polypeptide; Short=GRPP; Contains: RecName: Full=Oxyntomodulin; Short=OXY; Short=OXM; Contains: RecName: Full=Glucagon; Contains: RecName: Full=Glucagon-like peptide 1; Short=GLP-1; Contains: RecName: Full=Glucagon-like peptide 1(7-37); Short=GLP-1(7-37); Contains: RecName: Full=Glucagon-like peptide 1(7-36); Short=GLP-1(7-36); Contains: RecName: Full=Glucagon-like peptide 2; Short=GLP-2; Flags: Precursor; RecName: Full=Glucagon; Contains:RecName: Full=Glicentin; Contains:RecName: Full=Glicentin-related polypeptide; Contains:RecName: Full=Oxyntomodulin; Contains:RecName: Full=Glucagon; Contains:RecName: Full=Glucagon-like peptide 1; 7-37; 7-36 |
| Gene Names | GCG |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 180 aa
Average Mass: 20.972 kDa
Monoisotopic Mass: 20.959 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Hormone_2 1. | 53 | 80 | 60.0 | 8.8e-15 |
| --- cleavage 77 (inside Hormone_2 53..80) --- | ||||
| --- cleavage 79 (inside Hormone_2 53..80) --- | ||||
| Hormone_2 2. | 98 | 125 | 52.6 | 1.5e-12 |
| Hormone_2 3. | 146 | 173 | 44.0 | 5.9e-10 |
3. Sequence Information
Fasta Sequence: XSB0072.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] SRRAQQFLKW77-LLNVKRNRNN
Trp77 
Leu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser68 | Arg69 | Arg70 | Ala71 | Gln72 | Gln73 | Phe74 | Leu75 | Lys76 | Trp77 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu78 | Leu79 | Asn80 | Val81 | Lys82 | Arg83 | Asn84 | Arg85 | Asn86 | Asn87 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| NEDKRHSQGTFTSDYSKYLDSRRAQQFLKWLLNVKRNRNNIAKRHDEFERHAEGTFTSDV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 119.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 71.60 | 45 | 0 |
| 3 | Tetraodon nigroviridis | 70.50 | 3 | unnamed protein product |
| 4 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 59.70 | 2 | GLUC_MYOSC Glucagon precursor |
| 5 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 56.60 | 1 | AAB31092.1 |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 54.30 | 1 | glucagon II |
| 7 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 54.30 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 8 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 52.40 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 9 | Contains: Glucagon; Glucagon-like peptide | 52.00 | 4 | GLUC_AMICA Glucagon precursor |
| 10 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 52.00 | 1 | glucagon |
| 11 | Mus musculus | 51.60 | 6 | glucagon |
| 12 | Rattus norvegicus | 51.60 | 5 | glucagon |
| 13 | Macaca mulatta | 50.80 | 3 | PREDICTED: similar to glucagon preproprotein |
| 14 | Canis lupus familiaris | 50.80 | 1 | glucagon |
| 15 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 50.40 | 1 | glucagon G-29 |
| 16 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 49.70 | 1 | GLUC_LAMFL Glucagon gb |
| 17 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 49.30 | 1 | glucagon |
| 18 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to preproglucagon |
| 19 | Gallus gallus | 47.40 | 4 | glucagon isoform 1 |
| 20 | Meleagris gallopavo | 47.40 | 2 | preproglucagon B |
| 21 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 47.40 | 1 | GLUC_HELSU Glucagon precursor |
| 22 | Xenopus laevis | 45.80 | 4 | proglucagon II |
| 23 | Hoplobatrachus rugulosus | 45.80 | 1 | AF324209_1 proglucagon |
| 24 | deshis1, Desphe6, Glu9 | 45.40 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 25 | Canis familiaris | 44.30 | 2 | PREDICTED: similar to Vasoactive intestinal peptid |
| 26 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 44.30 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 27 | Bos taurus | 43.90 | 5 | vasoactive intestinal peptide |
| 28 | Capra hircus | 43.10 | 1 | glucagon |
| 29 | Bufo marinus | 42.40 | 1 | proglucagon |
| 30 | Squalus acanthias | 42.40 | 1 | proglucagon |
| 31 | Pan troglodytes | 41.60 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 32 | Xenopus tropicalis | 41.60 | 1 | glucagon |
| 33 | Danio rerio | 40.80 | 4 | hypothetical protein LOC494052 |
| 34 | Heloderma suspectum | 40.80 | 2 | proglucagon |
| 35 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 36 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 40.40 | 1 | VIP_MOUSE VIP peptides precursor |
| 37 | Protopterus dolloi | 40.40 | 1 | proglucagon |
| 38 | Sebastes caurinus | 39.70 | 4 | proglucagon I |
| 39 | Heloderma horridum | 39.70 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 40 | Arvicanthis ansorgei | 39.70 | 1 | vasoactive intestinal polypeptide |
| 41 | Oncorhynchus tshawytscha | 39.30 | 1 | S78474_1 proglucagon |
| 42 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 38.90 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 43 | Agkistrodon piscivorus | 38.90 | 1 | proglucagon |
| 44 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 38.90 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 45 | Ambloplites rupestris | 38.50 | 1 | proglucagon |
| 46 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.50 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 47 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 48 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 37.70 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 49 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 37.00 | 1 | glucagon-like peptide, GLP |
| 50 | Neoceratodus forsteri | 36.60 | 1 | proglucagon |
| 51 | Heloderma suspectum, venom, Peptide, 39 aa | 35.00 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 52 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.00 | 1 | GLUC_LEPSP Glucagon precursor |
| 53 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 33.90 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 54 | Contains: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 33.10 | 1 | VIP_MELGA VIP peptides precursor |
| 55 | swine, intestines, Peptide Partial, 56 aa | 33.10 | 1 | secretin precursor, N-prosecretin, secretin-(-9 to |
| 56 | Anas platyrhynchos | 32.70 | 2 | vasoactive intestinal polypeptide |
| 57 | Hydrolagus colliei | 32.70 | 1 | proglucagon |
| 58 | synthetic construct | 32.70 | 1 | Homo sapiens glucagon |
| 59 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 32.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 60 | Anser anser | 32.70 | 1 | VIP |
| 61 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 32.70 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 62 | Phodopus sungorus | 32.30 | 1 | glucagon precursor |
| 63 | Sus scrofa | 32.30 | 1 | glucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||||||||||||||||||||||||| |++|#|+| ||||||||||||||||||||||||| Sbjct 131 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 189 |
| N/A | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIA 89 |||||||||||||||||||| |++|#|+| |||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIA 37 |
| Tetraodon nigroviridis | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||+ |+|| |++|#|+| ||+ + |+ |||+||||||| Sbjct 49 KRHSEGTFSNDYSKYLEDRKAQDFVRW#LMNNKRSGFSSAE-----TRHADGTFTSDV 100 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | ||+|||++||||||++|||| |++|#| | + ||+||||||| Sbjct 27 KXHSEGTFSNDYSKYLETRRAQDFVQW#LKN--------SXXXXXXXXHADGTFTSDV 75 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRN 84 ||+||||||||||+|+|||+ |++|#|++ ||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMSTKRN 32 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRN 84 ||+|||++||||||++|||| |++|#| | ||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |||||||||||||||+|||| |++|#|++ Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQW#LMS 28 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRN 84 ||+|||++||||||+ |+|| |++|#|+| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRW#LMNNKRS 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |||||||+|||||+|+|||| |++|#|++ Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMS 28 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |||||||+|||||+|+|||| |++|#|++ Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMS 28 |
| Mus musculus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| |||||||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIAEELGRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 |
| Rattus norvegicus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| |||||||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIAEELGRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 |
| Macaca mulatta | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| |||||||||||||||||||||||||| Sbjct 131 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 190 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 176 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEELGRRHADGSFS 235 Query 105 SDV 107 ++ Sbjct 236 DEM 238 |
| Canis lupus familiaris | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| |||+|||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEEFRRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 ||+||||||||||+|+|||+ |++|#|++ Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMS 28 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 ||||+|||||||||||++|+ |+ |#|+| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIW#LMN 28 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 ||+|||||||||||++++|+ |++|#|+| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRW#LMN 28 |
| Monodelphis domestica | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|++ ||| | +||||||||||||||||||| Sbjct 47 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGNKVAKRHDEFERHAEGTFTSDV 106 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR---NNIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + | + + |||+|+|+ Sbjct 92 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRAFPEEVTIVEELGRRHADGSFS 151 Query 105 SDV 107 ++ Sbjct 152 DEM 154 |
| Gallus gallus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRN------------------RNNIA 89 || |||||||||||||||||||||| |++|#|++ ||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDKFPDQLSSNAIS 109 Query 90 KRHDEFERHAEGTFTSDV 107 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 105 SDV 107 ||+ Sbjct 173 SDI 175 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNI 88 +||+ |||||| +| || |++||||#|+| | + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Meleagris gallopavo | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRN------------------RNNIA 89 || |||||||||||||||||||||| |++|#|++ ||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDEFPDQLSSNAIS 109 Query 90 KRHDEFERHAEGTFTSDV 107 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 105 SDV 107 ||+ Sbjct 173 SDI 175 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNI 88 +||+ |||||| +| || |++||||#|+| | + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKR------------------NRNNIA 89 || |||||||||||||||||+|||| |++|#|+| || + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 90 KRHDEFERHAEGTFTSDV 107 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAK---RHDEFERHAEGTFTS 105 | +||+ | +||| | ||+ + |++|+ |#|+| + |+ + + | |||+||||| Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFLEEAGTADDIGRRHADGTFTS 171 Query 106 D 106 | Query 106 D 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNI 88 +||+ |||||||++ || |+||||#|+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKW#LINQKVTQRDL 199 |
| Xenopus laevis | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||||||||||||||||| |++|#|+| ||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | +||++||+|+| ++||+ + + |++|#|+ | + + ||||||||+|+ Sbjct 138 EIERHAEGTYTNDVTEYLEEKATKAFIEW#LIKGK-------PKKIRYSRHAEGTFTNDM 189 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRH 92 ||++||||+| + ||+ + |++|+ |#|+| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LINGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 || |||||||||||||||||||||| |++|#|+| ||+ |+||+ +||||||||+|+|| Sbjct 48 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNSKRS-GGISKRNVQFERHAEGTYTNDV 106 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFE-RHAEGTFTSD 106 ||++|||||| + ||+ + |++|+ |#|+ + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDW#LIKGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| +++|+ + |++|+ |#|+ | + ++ ||||||||||+ Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LIKGKPKKQRLS-------RHAEGTFTSDM 144 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |+||+ |+||||++| || + ||+|| |#++| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDW#IIN 208 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |||| ||+||||||||||| |++|#|+| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQW#LMN 26 |
| Canis familiaris | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||+|+ | |+++|+ #|+ || |||++ +||++ || + Sbjct 76 SRNARHADGVFTSDFSRLLGQLSAKKYLES#LIG-KRVGNNISEDQGPIKRHSDAVFTDN 133 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||||||||||++++|+ |++|#|+| || + + + |||+||||+|+ Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRW#LMNAKRGGSELQR------RHADGTFTNDM 91 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR---NNIAKRHDEFERHAE 100 +||+ ||||+| + |||++ |+ |+ |#| ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSW#LARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+++|+ #|+ || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLES#LIG-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Capra hircus | Query 86 NNIAKRHDEFERHAEGTFTSDV 107 |||||||||||||||||||||| Query 86 NNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR 85 +| +||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 45 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LL--NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||++|||||| + +|+ + |++|+ |#|+ ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDW#LIKGRPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| +++|+ + |++|+ |#|| | |+ ||||||||||+ Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LL------KGIPKK-QRLSRHAEGTFTSDM 72 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |+||+ |+||||++| || + ||+|| |#++| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDW#IIN 137 Query 74 FLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | +|#|+| ||+ +++|+ +||||||||+|+|| Sbjct 2 FAQW#LMNSKRS-GGMSRRNVQFERHAEGTYTNDV 34 |
| Squalus acanthias | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#L--LNVKRNRNNIAKRHDEFERHAEGTF 103 ++ |||++||+||| | +|++|+ #| | ++| +|+||| | || ||++ Sbjct 20 DKTKRHAEGTYTSDVDSLSDYFKAKRFVDS#LTSYNKRQNGRSISKRHVESTRHTEGSY 77 Query 67 DSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |+|||+ |++|#|++ ||| |+ +||||||+|||| Sbjct 1 DNRRAKDFVQW#LMSTKRN-------GDKTKRHAEGTYTSDV 34 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEF----------ERH 98 | ||++|++ | | ||+++ |+ |+ |#|+ | | + | || Sbjct 68 ESTRHTEGSYR-DISSYLEAKAAKDFINW#LIK-GRGRREFPEESKEIVNEVIPEEMDRRH 125 Query 99 AEGTFTSDV 107 |+|||||++ Sbjct 126 ADGTFTSEI 134 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFE 96 |+||+ |||||+ + ||+ |++|| |#+|| | | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNW#ILNSK----TIQSRDSEIE 164 |
| Pan troglodytes | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| ||| +++| ||||||||||| Sbjct 970 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN-SSVA------YRHAEGTFTSDV 1022 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR 85 ||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 1045 |
| Xenopus tropicalis | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||||||||||||||||| |++|#|+| ||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFIQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| ++||+ + |++|++|#|+| | + + ||||||||+|+ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEW#LINGK-------PKKIRYSRHAEGTFTNDM 189 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFE---RHAEGTFTSDV 107 ||++||||+| + ||+ + |++|+ |#|+ | + | ++ | | |||+|+||+|+ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LIK-GRPKRNFSEAHSVEEMDRRHADGSFTNDI 236 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 |+||+ |+||+| +| || ||+|| |#++| + Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDW#VINTQ 256 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||| |++|#|+| ||| ++ +||||||+|||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQW#LMNAKRNGGSV-------KRHAEGTYTSDV 97 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#L 78 |||++||+||| | || + || |+ |#| Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAW#L 113 |
| Heloderma suspectum | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKR------------------NRNNIA 89 || |||||||||||||||||+|||| |++|#|+| || + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 90 KRHDEFERHAEGTFTSDV 107 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR 85 | +||+ | +||| | ||+ + |++|+ |#|+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRR 148 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 +|||+|||++||||||++|||| |++|#|+| ||+ |||+||+|||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQW#LMNSKRS-------DSPARRHADGTYTSDV 98 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEF--ERHAEGTFTSDV 107 +||+ ||+||| | || + |+ |+ |#| + + + + | + || +|+||||| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITW#LKSGQPKPDAVETRSVDTLRRRHVDGSFTSDV 145 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRH 92 +|| |+|||| +| ||| |+++|+|#++| + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQW#VMNSPSSAS--GKRH 173 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||||+ | |+++|+ #|+ || ++|++ +||++ || + Sbjct 76 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Protopterus dolloi | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||| |||+| |+++ | ++ #|++ || ++|||+| |||||||+|||+ Sbjct 28 EAKRHSQGTFMSDYAKLLEAKHALDLVQR#LMSTKRT-GAVSKRHNEIERHAEGTYTSDI 85 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFE-RHAEGTFTSD 106 || +||++||+||| | ||+ + +|++|#|+ + |+ +| + |||+|| ||| Sbjct 71 NEIERHAEGTYTSDISSYLEGQAVNEFIRW#LMKGRGRRDFSETDIEEMDRRHADGTVTSD 130 Query 107 V 107 + Sbjct 131 I 131 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 |+||+ || ||| + |+| ++|| |#|+| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNW#LINAK 151 |
| Sebastes caurinus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++|||+||+ |+|| |++|#|+| ||+ || +|||+||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRW#LMNNKRS------GADE-KRHADGTFTSDV 97 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDE--FERHAEGTFTSD 106 ++|||+ |||||| | || + + |+ #| + + | + + | || +|+|||| Sbjct 84 DEKRHADGTFTSDVSSYLKDQAIKDFVNR#LKSGQVRRESETEWRGEAFSRRHVDGSFTSD 143 Query 107 V 107 | Query 107 V 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDE 94 +|| |+|||| +| ||| |+++| |#++ | + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLW#VMTSKPSGESKKRQEDQ 176 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 |||| |||||| || ++ + |++|#| | Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEW#LKN 75 |
| Arvicanthis ansorgei | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||||+ | |+++|+ #|+ || ++| + +||++ || + Sbjct 59 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||++||||| + | || |++|#|+| ||+ +|||+||+|||| Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 48 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR 85 |||+ ||+||| | || + |+ |+ |#| + + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARR 71 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 || |+|||++ |||| + | |+ || |#|+| ||+ +|||+||+|||| Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLN--VKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||+ ||+||| | || + |+ |+ |#| + +| + || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGPARRESAEESMNGPMSRRHVDGSFTSDV 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++| |#++ | + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Agkistrodon piscivorus | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRH---DEFERHAEGTFTS 105 | +||+ ||+||| | ||+ + |++|+ |#|+| + |+ | | |||+||||| Sbjct 32 EYERHADGTYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFSEGAHTGEDLGRRHADGTFTS 91 Query 106 D 106 | Query 106 D 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNI 88 +||+ |||||||+| || |+||||#|+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKW#LINQKVTQRDL 119 Query 66 LDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |+ | + || #| + | +|+ | |+||||+||+|||+ Sbjct 9 LEDREKENFLDQ#LAS-----NGLARPHAEYERHADGTYTSDI 45 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||| + | || |++|#|+| ||+ +|||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNI--AKRHDEFERHAEGTFTSDV 107 |||+ ||+||| | || + |+ |+ |#| + + | + ++ || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARRESAEESRNGPMSRRHVDGSFTSDV 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++| |#++ | + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSD 106 |||||||+||+ ||+ |+|| |++|#|+| | |+ |++ |||+|||| | Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRW#LMNNK--RSGAAEK-----RHADGTFTDD 47 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||| | | + + |+ #| + + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAK#LKSGQDRREPETDRRREAFSRRHVEGSFTSDI 95 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 |+ |+|||| +| ||+ |++|| |#|++ | Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNW#LISTK 30 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||+|||||||+|| ++|+ |+ |#||| || + + +||++|+||+|+ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTW#LLNTKRRGVDAQAGANLEKRHSDGSFTNDM 98 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#L 78 | +|||| |+||+| + || |+ ||+|#| Sbjct 84 NLEKRHSDGSFTNDMNVMLDRMSAKNFLEW#L 114 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||| |++|#| | ||| | |||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN--------GLFRRHADGTYTSDV 98 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#L 78 +||+ ||+||| | || + |+ |+ |#| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSW#L 114 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#L 78 |+ ||||+| + |||++ |+ |+ |#| Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSW#L 26 |
| Neoceratodus forsteri | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||| |||+| |++| | |++ #|+| ||| ++||| | |||||||+|||+ Sbjct 20 EAKRHSQGTFMSDYAKLLEARHALDFVQR#LMNTKRN-GGVSKRHSEIERHAEGTYTSDI 77 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEF-ERHAEGTFTSD 106 +| +||++||+||| | ||+ + | +|++|#|| + |+ +| |||+|| |+| Sbjct 63 SEIERHAEGTYTSDISSYLEGQAANEFVRW#LLKGRGRRDFSDTDAEEMGRRHADGTITND 122 Query 107 V 107 + Sbjct 123 M 123 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 +||+ || |+| + |+| ++|| |#|+| | Sbjct 112 RRHADGTITNDMNNVLESIATREFLNW#LINSK 143 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLN 80 | +|||||| || ++ + |++|#| | Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEW#LKN 28 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||||+|||||||+|||| |++|#|++ ||+ | ||+||+|||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQW#LMSTKRS-GGITXXXXXXXXHADGTYTSDV 54 Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#L 78 |+ ||+||| | || + |++|+ |#| Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTW#L 70 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNR 85 |+ || ||| | +|+ + ++|+ |#|++ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAW#LVSGRGRR 33 |
| Contains: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| #+| ||++ | || || | Sbjct 127 KRHSDAVFTDNYSRFRKQMAVKKYLNS#VLTGKRSQEELNPAKLADEAE 174 |
| swine, intestines, Peptide Partial, 56 aa | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKW#LL 79 ||| |||||+ |+ || | |+ |+ #|+ Sbjct 29 RHSDGTFTSELSRLRDSARLQRLLQG#LV 56 |
| Anas platyrhynchos | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| #+| ||++ | +| || | Sbjct 11 KRHSDAVFTDNYSRFRKQMAVKKYLNS#VLTGKRSQEELNPSKLRDEAE 58 |
| Hydrolagus colliei | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||+ | |+||||||||+|| + |++|#||+ ||| | |+ +|||+| +|||| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQW#LLSTKRNGANT----DKTKRHADGIYTSDV 82 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNN--IAKRHDEFERHAEGTFTS 105 ++ |||+ | +||| + | ++++|++ #| | + +|+ ++||| | | | + + Sbjct 68 DKTKRHADGIYTSDVASLTDYLKSKRFVES#LSNYNKRQNDRRMSKRHVEGARRTEEDYPN 127 Query 106 D 106 | Query 106 D 106 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFE 96 | | ++ + +|+| ||+++ |+ |+ |#|+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAKAAKDFIDW#LIK-GQGRRDFAEESREIE 162 |
| synthetic construct | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||| |++|#|+| |||||||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEELGRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 +||+ |+|+ + + ||+ |+ |+ |#|+ | Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINW#LIQTK 175 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN 86 ||+||| | || + |++|+ |#| + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSW#LKTGRGRRD 33 |
| Anser anser | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| #+| ||++ | +| || | Sbjct 25 KRHSDAVFTDNYSRFRKQMAVKKYLNS#VLTGKRSQEELNPSKLRDEAE 72 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||+ |+||+|++|#|+| | |+ +|++ |||+||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRW#LMNNK--RSGVAEK-----RHADGTFTSDV 100 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFL 75 +|||+ |||||| | || + + |+ Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFV 113 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 |||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ ++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELGRRHADGSFSDEM 55 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 +||+ |+|+ + + ||| + |+ |#|+ | Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINW#LIQTK 75 |
| Sus scrofa | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||||||||||||||||||||| |++|#|+| |||+|||||||||||||||||||||| Sbjct 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELRRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKW#LLNVK 82 +||+ |+|+ + + ||+ + |+ |#||+ | Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINW#LLHTK 175 |
[Site 2] RAQQFLKWLL79-NVKRNRNNIA
Leu79 Asn
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg70 | Ala71 | Gln72 | Gln73 | Phe74 | Leu75 | Lys76 | Trp77 | Leu78 | Leu79 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asn80 | Val81 | Lys82 | Arg83 | Asn84 | Arg85 | Asn86 | Asn87 | Ile88 | Ala89 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DKRHSQGTFTSDYSKYLDSRRAQQFLKWLLNVKRNRNNIAKRHDEFERHAEGTFTSDVSS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 115.00 | 10 | glucagon, isoform CRA_b |
| 2 | Tetraodon nigroviridis | 73.60 | 3 | unnamed protein product |
| 3 | N/A | 71.60 | 45 | 0 |
| 4 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 62.80 | 2 | GLUC_MYOSC Glucagon precursor |
| 5 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 56.60 | 1 | AAB31092.1 |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 54.30 | 1 | glucagon II |
| 7 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 54.30 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 8 | Mus musculus | 52.40 | 6 | glucagon |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 52.40 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Contains: Glucagon; Glucagon-like peptide | 52.00 | 4 | GLUC_AMICA Glucagon precursor |
| 11 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 52.00 | 1 | glucagon |
| 12 | Rattus norvegicus | 51.20 | 5 | glucagon |
| 13 | Macaca mulatta | 50.40 | 3 | PREDICTED: similar to glucagon preproprotein |
| 14 | Canis lupus familiaris | 50.40 | 1 | glucagon |
| 15 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 50.40 | 1 | glucagon G-29 |
| 16 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 49.70 | 1 | GLUC_LAMFL Glucagon gb |
| 17 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 49.30 | 1 | glucagon |
| 18 | Monodelphis domestica | 48.50 | 3 | PREDICTED: similar to preproglucagon |
| 19 | Gallus gallus | 47.40 | 5 | glucagon isoform 1 |
| 20 | Meleagris gallopavo | 47.40 | 2 | preproglucagon B |
| 21 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 47.40 | 1 | GLUC_HELSU Glucagon precursor |
| 22 | Xenopus laevis | 45.80 | 4 | proglucagon II |
| 23 | Hoplobatrachus rugulosus | 45.80 | 1 | AF324209_1 proglucagon |
| 24 | deshis1, Desphe6, Glu9 | 45.40 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 25 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 44.30 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 26 | Bos taurus | 43.90 | 5 | vasoactive intestinal peptide |
| 27 | Canis familiaris | 43.90 | 2 | PREDICTED: similar to Vasoactive intestinal peptid |
| 28 | Bufo marinus | 42.70 | 1 | proglucagon |
| 29 | Capra hircus | 42.00 | 1 | glucagon |
| 30 | Agkistrodon piscivorus | 42.00 | 1 | proglucagon |
| 31 | Pan troglodytes | 41.60 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 32 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 33 | Xenopus tropicalis | 41.60 | 1 | glucagon |
| 34 | Danio rerio | 40.80 | 4 | hypothetical protein LOC494052 |
| 35 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 36 | Protopterus dolloi | 40.40 | 1 | proglucagon |
| 37 | Heloderma suspectum | 40.00 | 2 | proglucagon |
| 38 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 40.00 | 1 | VIP_MOUSE VIP peptides precursor |
| 39 | Sebastes caurinus | 39.70 | 4 | proglucagon I |
| 40 | Heloderma horridum | 39.70 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 41 | Oncorhynchus tshawytscha | 39.30 | 1 | S78474_1 proglucagon |
| 42 | Arvicanthis ansorgei | 39.30 | 1 | vasoactive intestinal polypeptide |
| 43 | Ambloplites rupestris | 38.90 | 1 | proglucagon |
| 44 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 38.90 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 45 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 38.90 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 46 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.50 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 47 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 37.70 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 48 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 37.00 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 49 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 37.00 | 1 | glucagon-like peptide, GLP |
| 50 | Neoceratodus forsteri | 36.60 | 1 | proglucagon |
| 51 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.00 | 1 | GLUC_LEPSP Glucagon precursor |
| 52 | Heloderma suspectum, venom, Peptide, 39 aa | 35.00 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 53 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 33.90 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 54 | swine, intestines, Peptide Partial, 56 aa | 33.10 | 1 | secretin precursor, N-prosecretin, secretin-(-9 to |
| 55 | Contains: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 33.10 | 1 | VIP_MELGA VIP peptides precursor |
| 56 | Anas platyrhynchos | 32.70 | 2 | vasoactive intestinal polypeptide |
| 57 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 32.70 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 58 | Anser anser | 32.70 | 1 | VIP |
| 59 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 32.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 60 | synthetic construct | 32.70 | 1 | Homo sapiens glucagon |
| 61 | Hydrolagus colliei | 32.30 | 1 | proglucagon |
| 62 | Phodopus sungorus | 32.30 | 1 | glucagon precursor |
| 63 | Sus scrofa | 32.30 | 1 | glucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||||||||||||||||||||||| |++||+#| ||||||||||||||||||||||||| Sbjct 133 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 189 |
| Tetraodon nigroviridis | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||+ |+|| |++||+#| ||+ + |+ |||+||||||||| Sbjct 49 KRHSEGTFSNDYSKYLEDRKAQDFVRWLM#NNKRSGFSSAE-----TRHADGTFTSDVSS 102 |
| N/A | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIA 89 |||||||||||||||||||| |++||+#| |||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIA 37 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 | ||+|||++||||||++|||| |++|| #| + ||+||||||||| Sbjct 27 KXHSEGTFSNDYSKYLETRRAQDFVQWLK#N--------SXXXXXXXXHADGTFTSDVSS 77 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRN 84 ||+||||||||||+|+|||+ |++||+#+ ||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#STKRN 32 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRN 84 ||+|||++||||||++|||| |++|| #| ||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |||||||||||||||+|||| |++||+#+ Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQWLM#S 28 |
| Mus musculus | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||||||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIAEELGRRHADGSFSDEM 155 Query 108 SS 109 |+ Sbjct 156 ST 157 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRN 84 ||+|||++||||||+ |+|| |++||+#| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRWLM#NNKRS 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |||||||+|||||+|+|||| |++||+#+ Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#S 28 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |||||||+|||||+|+|||| |++||+#+ Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#S 28 |
| Rattus norvegicus | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||||||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIAEELGRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 |
| Macaca mulatta | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||||||||||||||||||||||||||| Sbjct 133 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 192 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 179 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEELGRRHADGSFSDEM 238 Query 108 SS 109 ++ Sbjct 239 NT 240 |
| Canis lupus familiaris | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEEFRRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 ||+||||||||||+|+|||+ |++||+#+ Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#S 28 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 ||||+|||||||||||++|+ |+ ||+#| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIWLM#N 28 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 ||+|||||||||||++++|+ |++||+#| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRWLM#N 28 |
| Monodelphis domestica | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#+ ||| | +||||||||||||||||||||| Sbjct 49 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGNKVAKRHDEFERHAEGTFTSDVSS 108 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR---NNIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + | + + |||+|+|+ ++ Sbjct 95 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRAFPEEVTIVEELGRRHADGSFSDEM 154 Query 108 SS 109 ++ Sbjct 155 NT 156 |
| Gallus gallus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRN------------------RNNIAKRH 92 |||||||||||||||||||||| |++||+#+ ||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDKFPDQLSSNAISKRH 112 Query 93 DEFERHAEGTFTSDVSS 109 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAK---RHDEFERHAEGTFTSDV 107 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 108 S 108 + Sbjct 176 N 176 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNI 88 +||+ |||||| +| || |++|||||+#| | + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Meleagris gallopavo | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRN------------------RNNIAKRH 92 |||||||||||||||||||||| |++||+#+ ||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDEFPDQLSSNAISKRH 112 Query 93 DEFERHAEGTFTSDVSS 109 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAK---RHDEFERHAEGTFTSDV 107 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 108 S 108 + Sbjct 176 N 176 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNI 88 +||+ |||||| +| || |++|||||+#| | + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKR------------------NRNNIAKRH 92 |||||||||||||||||+|||| |++||+#| || + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 93 DEFERHAEGTFTSDVSS 109 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAK---RHDEFERHAEGTFTSD 106 +||+ | +||| | ||+ + |++|+ ||+#| + |+ + + | |||+|||||| Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFLEEAGTADDIGRRHADGTFTSD 172 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNI 88 +||+ |||||||++ || |+|||||+#| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKWLI#NQKVTQRDL 199 |
| Xenopus laevis | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||||||||||||||||||| |++||+#| ||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| ++||+ + + |++||+# | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKATKAFIEWLI#KGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRH 92 ||++||||+| + ||+ + |++|+ ||+#| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#NGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||||||||||||||||||| |++||+#| ||+ |+||+ +||||||||+|+||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NSKRS-GGISKRNVQFERHAEGTYTNDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| +++|+ + |++|+ ||+# | + ++ ||||||||||++| Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDWLI#KGKPKKQRLS-------RHAEGTFTSDMTS 146 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFE-RHAEGTFTSD 106 ||++|||||| + ||+ + |++|+ ||+# + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDWLI#KGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |+||+ |+||||++| || + ||+|| |++#| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDWII#N 208 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |||| ||+||||||||||| |++||+#| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQWLM#N 26 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||||||||||++++|+ |++||+#| || + + + |||+||||+|++| Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRWLM#NAKRGGSELQR------RHADGTFTNDMTS 93 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR---NNIAKRHDEFERHAE 100 +||+ ||||+| + |||++ |+ |+ || # ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSWLA#RSDKSRRDGGDHLAENSEDKRHAE 132 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+++|+ |+# || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLESLI#G-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||+|+ | |+++|+ |+# || |||++ +||++ || + Sbjct 80 RHADGVFTSDFSRLLGQLSAKKYLESLI#G-KRVGNNISEDQGPIKRHSDAVFTDN 133 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL--#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||++|||||| + +|+ + |++|+ ||+ # ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDWLIKG#RPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| +++|+ + |++|+ |||# | |+ ||||||||||++| Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDWLL#------KGIPKK-QRLSRHAEGTFTSDMTS 74 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |+||+ |+||||++| || + ||+|| |++#| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDWII#N 137 Query 74 FLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 | +||+#| ||+ +++|+ +||||||||+|+||+ Sbjct 2 FAQWLM#NSKRS-GGMSRRNVQFERHAEGTYTNDVT 35 |
| Capra hircus | Query 86 NNIAKRHDEFERHAEGTFTSDVSS 109 |||||||||||||||||||||||| Query 86 NNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR 85 +||++|||||| | ||+ + |++|+ ||+# + | Sbjct 11 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 45 |
| Agkistrodon piscivorus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRH---DEFERHAEGTFTSD 106 +||+ ||+||| | ||+ + |++|+ ||+#| + |+ | | |||+|||||| Sbjct 34 ERHADGTYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFSEGAHTGEDLGRRHADGTFTSD 92 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNI 88 +||+ |||||||+| || |+|||||+#| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKWLI#NQKVTQRDL 119 Query 66 LDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |+ | + || | #+ | +|+ | |+||||+||+|||+|| Sbjct 9 LEDREKENFLDQLA#S-----NGLARPHAEYERHADGTYTSDISS 47 |
| Pan troglodytes | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| ||| +++| ||||||||||||| Sbjct 972 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN-SSVA------YRHAEGTFTSDVSS 1024 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR 85 ||++|||||| | ||+ + |++|+ ||+# + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 1045 |
| Squalus acanthias | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWL--L#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||++||+||| | +|++|+ | #| ++| +|+||| | || ||++ |+| Sbjct 23 KRHAEGTYTSDVDSLSDYFKAKRFVDSLTSY#NKRQNGRSISKRHVESTRHTEGSY-RDIS 81 Query 109 S 109 | Query 109 S 109 Query 67 DSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |+|||+ |++||+#+ ||| |+ +||||||+|||| | Sbjct 1 DNRRAKDFVQWLM#STKRNG-------DKTKRHAEGTYTSDVDS 36 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFE 96 |+||+ |||||+ + ||+ |++|| |+|#| | | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNWIL#NSK----TIQSRDSEIE 164 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEF----------ERHAEG 101 ||++|++ | | ||+++ |+ |+ ||+# | | + | |||+| Sbjct 71 RHTEGSYR-DISSYLEAKAAKDFINWLI#K-GRGRREFPEESKEIVNEVIPEEMDRRHADG 128 Query 102 TFTSDVS 108 ||||+++ Sbjct 129 TFTSEIN 135 |
| Xenopus tropicalis | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||||||||||||||||||| |++||+#| ||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFIQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| ++||+ + |++|++||+#| | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEWLI#NGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFE---RHAEGTFTSDVS 108 ||++||||+| + ||+ + |++|+ ||+# | + | ++ | | |||+|+||+|++ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#K-GRPKRNFSEAHSVEEMDRRHADGSFTNDIN 237 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 |+||+ |+||+| +| || ||+|| |++#| + Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDWVI#NTQ 256 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||| |++||+#| ||| ++ +||||||+|||||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQWLM#NAKRNGGSV-------KRHAEGTYTSDVSS 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWL 78 |||++||+||| | || + || |+ || Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAWL 113 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +|||+|||++||||||++|||| |++||+#| ||+ |||+||+|||||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQWLM#NSKRS-------DSPARRHADGTYTSDVSS 100 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEF--ERHAEGTFTSDVS 108 +||+ ||+||| | || + |+ |+ || #+ + + + | + || +|+|||||+ Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITWLK#SGQPKPDAVETRSVDTLRRRHVDGSFTSDVN 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRH 92 +|| |+|||| +| ||| |+++|+|++#| + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQWVM#NSPSSAS--GKRH 173 |
| Protopterus dolloi | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||| |||+| |+++ | ++ |+#+ || ++|||+| |||||||+|||+|| Sbjct 30 KRHSQGTFMSDYAKLLEAKHALDLVQRLM#STKRT-GAVSKRHNEIERHAEGTYTSDISS 87 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFE-RHAEGTFTSDVSS 109 +||++||+||| | ||+ + +|++||+# + |+ +| + |||+|| |||++| Sbjct 74 ERHAEGTYTSDISSYLEGQAVNEFIRWLM#KGRGRRDFSETDIEEMDRRHADGTVTSDINS 133 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 |+||+ || ||| + |+| ++|| ||+#| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNWLI#NAK 151 |
| Heloderma suspectum | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKR------------------NRNNIAKRH 92 |||||||||||||||||+|||| |++||+#| || + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 93 DEFERHAEGTFTSDVSS 109 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR 85 +||+ | +||| | ||+ + |++|+ ||+#| + | Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRR 148 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+++|+ |+# || ++|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Sebastes caurinus | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++|||+||+ |+|| |++||+#| ||+ || +|||+||||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRWLM#NNKRS------GADE-KRHADGTFTSDVSS 99 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||||| | || + + |+ | #+ + | + + | || +|+||||| Sbjct 85 EKRHADGTFTSDVSSYLKDQAIKDFVNRLK#SGQVRRESETEWRGEAFSRRHVDGSFTSDV 144 Query 108 S 108 + Sbjct 145 N 145 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDE 94 +|| |+|||| +| ||| |+++| |++# | + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLWVM#TSKPSGESKKRQEDQ 176 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 |||| |||||| || ++ + |++|| #| Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEWLK#N 75 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 | |||++||||| + | || |++||+#| ||+ +|||+||+|||||+ Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 50 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR 85 |||+ ||+||| | || + |+ |+ || #+ + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARR 71 |
| Arvicanthis ansorgei | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+++|+ |+# || ++| + +||++ || + Sbjct 63 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||+||+ ||+ |+|| |++||+#| | |+ |++ |||+|||| | || Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRWLM#NNK--RSGAAEK-----RHADGTFTDDASS 50 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||| | | + + |+ | #+ + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAKLK#SGQDRREPETDRRREAFSRRHVEGSFTSDI 95 Query 108 S 108 + Sbjct 96 N 96 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 || |+|||++ |||| + | |+ || ||+#| ||+ +|||+||+|||||+ Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#N--VKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||+ ||+||| | || + |+ |+ || #+ +| + || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGPARRESAEESMNGPMSRRHVDGSFTSDVN 147 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++| |++# | + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||| + | || |++||+#| ||+ +|||+||+|||||+ Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNI--AKRHDEFERHAEGTFTSDVS 108 |||+ ||+||| | || + |+ |+ || #+ + | + ++ || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARRESAEESRNGPMSRRHVDGSFTSDVN 147 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++| |++# | + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 |+ |+|||| +| ||+ |++|| ||+#+ | Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNWLI#STK 30 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||| |++|| #| ||| | |||+||+|||||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN--------GLFRRHADGTYTSDVSS 100 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWL 78 +||+ ||+||| | || + |+ |+ || Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSWL 114 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||+|||||||+|| ++|+ |+ |||#| || + + +||++|+||+|++ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTWLL#NTKRRGVDAQAGANLEKRHSDGSFTNDMN 99 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWL 78 +|||| |+||+| + || |+ ||+|| Sbjct 86 EKRHSDGSFTNDMNVMLDRMSAKNFLEWL 114 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWL 78 |+ ||||+| + |||++ |+ |+ || Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSWL 26 |
| Neoceratodus forsteri | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||| |||+| |++| | |++ |+#| ||| ++||| | |||||||+|||+|| Sbjct 22 KRHSQGTFMSDYAKLLEARHALDFVQRLM#NTKRN-GGVSKRHSEIERHAEGTYTSDISS 79 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEF-ERHAEGTFTSDVSS 109 +||++||+||| | ||+ + | +|++|||# + |+ +| |||+|| |+|+++ Sbjct 66 ERHAEGTYTSDISSYLEGQAANEFVRWLL#KGRGRRDFSDTDAEEMGRRHADGTITNDMNN 125 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 +||+ || |+| + |+| ++|| ||+#| | Sbjct 112 RRHADGTITNDMNNVLESIATREFLNWLI#NSK 143 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||+|||||||+|||| |++||+#+ ||+ | ||+||+|||||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQWLM#STKRS-GGITXXXXXXXXHADGTYTSDVSS 56 Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWL 78 |+ ||+||| | || + |++|+ || Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTWL 70 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#N 80 | +|||||| || ++ + |++|| #| Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEWLK#N 28 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNR 85 |+ || ||| | +|+ + ++|+ ||+#+ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAWLV#SGRGRR 33 |
| swine, intestines, Peptide Partial, 56 aa | Query 52 RHSQGTFTSDYSKYLDSRRAQQFLKWLL# 79 ||| |||||+ |+ || | |+ |+ |+# Sbjct 29 RHSDGTFTSELSRLRDSARLQRLLQGLV# 56 |
| Contains: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| +|# ||++ | || || | Sbjct 127 KRHSDAVFTDNYSRFRKQMAVKKYLNSVL#TGKRSQEELNPAKLADEAE 174 |
| Anas platyrhynchos | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| +|# ||++ | +| || | Sbjct 11 KRHSDAVFTDNYSRFRKQMAVKKYLNSVL#TGKRSQEELNPSKLRDEAE 58 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||+ |+||+|++||+#| | |+ +|++ |||+||||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRWLM#NNK--RSGVAEK-----RHADGTFTSDVSS 102 Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFL 75 +|||+ |||||| | || + + |+ Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFV 113 |
| Anser anser | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN--NIAKRHDEFE 96 |||| || +||++ +++| +|# ||++ | +| || | Sbjct 25 KRHSDAVFTDNYSRFRKQMAVKKYLNSVL#TGKRSQEELNPSKLRDEAE 72 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN 86 ||+||| | || + |++|+ || # + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSWLK#TGRGRRD 33 |
| synthetic construct | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||||||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEELGRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 +||+ |+|+ + + ||+ |+ |+ ||+# | Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINWLI#QTK 175 |
| Hydrolagus colliei | Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||+ | |+||||||||+|| + |++|||#+ ||| | |+ +|||+| +||||+| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQWLL#STKRNGANT----DKTKRHADGIYTSDVAS 84 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNN--IAKRHDEFERHAEGTFTSDVS 108 |||+ | +||| + | ++++|++ | #| + +|+ ++||| | | | + +| | Sbjct 71 KRHADGIYTSDVASLTDYLKSKRFVESLS#NYNKRQNDRRMSKRHVEGARRTEEDYPNDFS 130 Query 109 S 109 | Query 109 S 109 Query 51 KRHSQGT------FTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFE 96 ||| +| + +|+| ||+++ |+ |+ ||+# + | + |+ | | Sbjct 112 KRHVEGARRTEEDYPNDFSSYLEAKAAKDFIDWLI#K-GQGRRDFAEESREIE 162 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDVSS 109 |||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELGRRHADGSFSDEMNT 57 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 +||+ |+|+ + + ||| + |+ ||+# | Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINWLI#QTK 75 |
| Sus scrofa | Query 50 DKRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||| |++||+#| |||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELRRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 Query 51 KRHSQGTFTSDYSKYLDSRRAQQFLKWLL#NVK 82 +||+ |+|+ + + ||+ + |+ |||#+ | Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINWLL#HTK 175 |
* References
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