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XSB0083 : Myelin basic protein

[ CaMP Format ]

This entry is computationally expanded from SB0045

* Basic Information

OrganismBos taurus (cattle)
Protein NamesMBP; Myelin A1 protein; 20 kDa microtubule-stabilizing protein
Gene NamesMBP
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P02687 N/A N/A P02687 N/A N/A N/A bta:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 169 aa

Average Mass: 18.323 kDa

Monoisotopic Mass: 18.312 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Myelin_MBP 1. 14168370.82.5e-108
--- cleavage 96 (inside Myelin_MBP 14..168) ---
--- cleavage 93 (inside Myelin_MBP 14..168) ---
--- cleavage 16 (inside Myelin_MBP 14..168) ---
--- cleavage 68 (inside Myelin_MBP 14..168) ---

3. Sequence Information

Fasta Sequence: XSB0083.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] HFFKNIVTPR96-TPPPSQGKGR

Arg96 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
His87Phe88Phe89Lys90Asn91Ile92Val93Thr94Pro95Arg96
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr97Pro98Pro99Pro100Ser101Gln102Gly103Lys104Gly105Arg106

Sequence conservation (by blast)

[Site 2] PVVHFFKNIV93-TPRTPPPSQG

Val93 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro84Val85Val86His87Phe88Phe89Lys90Asn91Ile92Val93
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr94Pro95Arg96Thr97Pro98Pro99Pro100Ser101Gln102Gly103

Sequence conservation (by blast)

[Site 3] SQRSKYLASA16-STMDHARHGF

Ala16 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser7Gln8Arg9Ser10Lys11Tyr12Leu13Ala14Ser15Ala16
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser17Thr18Met19Asp20His21Ala22Arg23His24Gly25Phe26

Sequence conservation (by blast)

[Site 4] HHAARTTHYG68-SLPQKAQGHR

Gly68 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
His59His60Ala61Ala62Arg63Thr64Thr65His66Tyr67Gly68
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser69Leu70Pro71Gln72Lys73Ala74Gln75Gly76His77Arg78

Sequence conservation (by blast)

* References

[PubMed ID: 5096093] Eylar EH, Brostoff S, Hashim G, Caccam J, Burnett P, Basic A1 protein of the myelin membrane. The complete amino acid sequence. J Biol Chem. 1971 Sep 25;246(18):5770-84.

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